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Assessment of the vitamin B12 status of pregnant women in Nigeria using plasma holotranscobalamin.

Vanderjagt DJ, Ujah IA, Ikeh EI, Bryant J, Pam V, Hilgart A, Crossey MJ, Glew RH - ISRN Obstet Gynecol (2011)

Bottom Line: The holoTCII concentration ranged from 13 to 128 pmol/L.Using a cutoff of 40 pmol/L, 36% of the women were classified as vitamin B12-deficient.These data underscore the importance of supplementing pregnant women in Nigeria with vitamin B12 in order to ensure adequate vitamin B12 status and decrease the risk for neural tube defects.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, MSC08 4670, Albuquerque, NM 87131-0001, USA.

ABSTRACT
Maternal vitamin B12 deficiency during pregnancy is an independent risk factor for neural tube defects and other neurological problems in infants. We determined the vitamin B12 status of 143 pregnant women in Nigeria representing all trimesters who presented to an antenatal clinic in Jos, Nigeria, using holotranscobalamin II levels (holoTCII), which is a measure of the vitamin B12 that is available for uptake into tissues. The holoTCII concentration ranged from 13 to 128 pmol/L. Using a cutoff of 40 pmol/L, 36% of the women were classified as vitamin B12-deficient. HoloTCII concentrations correlated negatively with plasma homocysteine levels (r = -0.24, P = 0.003) and positively with red blood cell folate concentrations (r = 0.28, P < 0.001). These data underscore the importance of supplementing pregnant women in Nigeria with vitamin B12 in order to ensure adequate vitamin B12 status and decrease the risk for neural tube defects.

No MeSH data available.


Related in: MedlinePlus

The relation between serum holotranscobalamin II concentrations and serum homocysteine concentrations; r = −0.24, P = 0.003.
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fig1: The relation between serum holotranscobalamin II concentrations and serum homocysteine concentrations; r = −0.24, P = 0.003.

Mentions: Thirty-six (25%) of the pregnant women had a plasma total vitamin B12 concentration below 148 pmol/L, the cutoff for vitamin B12 deficiency: 27% of women in the first trimester, 23% in the second trimester, and 32% in the third trimester. The plasma vitamin B12 concentrations of the subjects in the second and third trimesters were significantly lower than the values of subjects in the first trimester (P = 0.02, Table 2). The plasma vitamin B12 concentration was positively correlated with red blood cell folate level (Figure 1, r = 0.28, P < 0.001) and negatively correlated serum Hcys concentration (r = −0.24, P = 0.003).


Assessment of the vitamin B12 status of pregnant women in Nigeria using plasma holotranscobalamin.

Vanderjagt DJ, Ujah IA, Ikeh EI, Bryant J, Pam V, Hilgart A, Crossey MJ, Glew RH - ISRN Obstet Gynecol (2011)

The relation between serum holotranscobalamin II concentrations and serum homocysteine concentrations; r = −0.24, P = 0.003.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3140786&req=5

fig1: The relation between serum holotranscobalamin II concentrations and serum homocysteine concentrations; r = −0.24, P = 0.003.
Mentions: Thirty-six (25%) of the pregnant women had a plasma total vitamin B12 concentration below 148 pmol/L, the cutoff for vitamin B12 deficiency: 27% of women in the first trimester, 23% in the second trimester, and 32% in the third trimester. The plasma vitamin B12 concentrations of the subjects in the second and third trimesters were significantly lower than the values of subjects in the first trimester (P = 0.02, Table 2). The plasma vitamin B12 concentration was positively correlated with red blood cell folate level (Figure 1, r = 0.28, P < 0.001) and negatively correlated serum Hcys concentration (r = −0.24, P = 0.003).

Bottom Line: The holoTCII concentration ranged from 13 to 128 pmol/L.Using a cutoff of 40 pmol/L, 36% of the women were classified as vitamin B12-deficient.These data underscore the importance of supplementing pregnant women in Nigeria with vitamin B12 in order to ensure adequate vitamin B12 status and decrease the risk for neural tube defects.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, MSC08 4670, Albuquerque, NM 87131-0001, USA.

ABSTRACT
Maternal vitamin B12 deficiency during pregnancy is an independent risk factor for neural tube defects and other neurological problems in infants. We determined the vitamin B12 status of 143 pregnant women in Nigeria representing all trimesters who presented to an antenatal clinic in Jos, Nigeria, using holotranscobalamin II levels (holoTCII), which is a measure of the vitamin B12 that is available for uptake into tissues. The holoTCII concentration ranged from 13 to 128 pmol/L. Using a cutoff of 40 pmol/L, 36% of the women were classified as vitamin B12-deficient. HoloTCII concentrations correlated negatively with plasma homocysteine levels (r = -0.24, P = 0.003) and positively with red blood cell folate concentrations (r = 0.28, P < 0.001). These data underscore the importance of supplementing pregnant women in Nigeria with vitamin B12 in order to ensure adequate vitamin B12 status and decrease the risk for neural tube defects.

No MeSH data available.


Related in: MedlinePlus