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Prevalence and impact of thyroid disorders on maternal outcome in asian-Indian pregnant women.

Nambiar V, Jagtap VS, Sarathi V, Lila AR, Kamalanathan S, Bandgar TR, Menon PS, Shah NS - J Thyroid Res (2011)

Bottom Line: Forty percent of the hypothyroid patients did not have any high-risk characteristics.Conclusions.TAI and hypothyroidism were significantly associated with miscarriage.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Seth G. S. Medical College, Parel, Mumbai, Maharashtra 400012, India.

ABSTRACT
Aims. To establish the prevalence and the effect of thyroid dysfunction on pregnancy outcomes in Asian-Indian population. Subjects and Methods. The study cohort comprised of 483 consecutive pregnant women in the first trimester attending the antenatal clinic of a tertiary center in Mumbai, India. Thyroid hormone levels and thyroid peroxidase antibody were estimated. Patients with thyroid dysfunction were assessed periodically or treated depending on the severity. Subjects were followed until delivery. Results. The prevalence of hypothyroidism, Graves' disease, gestational transient thyrotoxicosis, and thyroid autoimmunity (TAI) was 4.8% (n = 24), 0.6% (n = 3), 6.4 % (n = 31), and 12.4% (n = 60), respectively. Forty percent of the hypothyroid patients did not have any high-risk characteristics. Hypothyroidism and TAI were associated with miscarriage (P = 0.02 and P = 0.001, resp.). Conclusions. The prevalence of hypothyroidism (4.8%) and TAI (12.4%) is high. TAI and hypothyroidism were significantly associated with miscarriage.

No MeSH data available.


Related in: MedlinePlus

Classification into various groups based on TSH and antibody status. TSH: Thyroid stimulating hormone in μIU/mL, TPOAb: thyroid peroxidase antibody. TRAb: TSH receptor antibody, hCG: human chorionic gonadotropin. TFT: thyroid function tests (FT3, FT4, TSH, and TPO titres in those with positive TPOAb). ATD: antithyroid drugs.
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Related In: Results  -  Collection


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fig1: Classification into various groups based on TSH and antibody status. TSH: Thyroid stimulating hormone in μIU/mL, TPOAb: thyroid peroxidase antibody. TRAb: TSH receptor antibody, hCG: human chorionic gonadotropin. TFT: thyroid function tests (FT3, FT4, TSH, and TPO titres in those with positive TPOAb). ATD: antithyroid drugs.

Mentions: Serum TSH and thyroid peroxidase antibody (TPOAb) were done as initial hormonal investigations, and the subjects were grouped based on the system proposed by Glinoer [4]. The division into different groups and their followup are shown in Figure 1. Subjects with TSH <2 μIU/mL and TPOAb negative (group 1) were considered as normal. Patients with TSH 2–4 μIU/mL, TPOAb positive (group 4) and TSH > 4 μIU/mL (group 5) were treated with thyroxine. The aim of the treatment was to maintain TSH in the range of 0.2–2 μIU/mL. Once treatment was initiated or changed, TSH was repeated at 6 weeks. Once TSH became normal, it was repeated 2 monthly. TPOAb titres were repeated every trimester in those with baseline positivity.


Prevalence and impact of thyroid disorders on maternal outcome in asian-Indian pregnant women.

Nambiar V, Jagtap VS, Sarathi V, Lila AR, Kamalanathan S, Bandgar TR, Menon PS, Shah NS - J Thyroid Res (2011)

Classification into various groups based on TSH and antibody status. TSH: Thyroid stimulating hormone in μIU/mL, TPOAb: thyroid peroxidase antibody. TRAb: TSH receptor antibody, hCG: human chorionic gonadotropin. TFT: thyroid function tests (FT3, FT4, TSH, and TPO titres in those with positive TPOAb). ATD: antithyroid drugs.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3140706&req=5

fig1: Classification into various groups based on TSH and antibody status. TSH: Thyroid stimulating hormone in μIU/mL, TPOAb: thyroid peroxidase antibody. TRAb: TSH receptor antibody, hCG: human chorionic gonadotropin. TFT: thyroid function tests (FT3, FT4, TSH, and TPO titres in those with positive TPOAb). ATD: antithyroid drugs.
Mentions: Serum TSH and thyroid peroxidase antibody (TPOAb) were done as initial hormonal investigations, and the subjects were grouped based on the system proposed by Glinoer [4]. The division into different groups and their followup are shown in Figure 1. Subjects with TSH <2 μIU/mL and TPOAb negative (group 1) were considered as normal. Patients with TSH 2–4 μIU/mL, TPOAb positive (group 4) and TSH > 4 μIU/mL (group 5) were treated with thyroxine. The aim of the treatment was to maintain TSH in the range of 0.2–2 μIU/mL. Once treatment was initiated or changed, TSH was repeated at 6 weeks. Once TSH became normal, it was repeated 2 monthly. TPOAb titres were repeated every trimester in those with baseline positivity.

Bottom Line: Forty percent of the hypothyroid patients did not have any high-risk characteristics.Conclusions.TAI and hypothyroidism were significantly associated with miscarriage.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Seth G. S. Medical College, Parel, Mumbai, Maharashtra 400012, India.

ABSTRACT
Aims. To establish the prevalence and the effect of thyroid dysfunction on pregnancy outcomes in Asian-Indian population. Subjects and Methods. The study cohort comprised of 483 consecutive pregnant women in the first trimester attending the antenatal clinic of a tertiary center in Mumbai, India. Thyroid hormone levels and thyroid peroxidase antibody were estimated. Patients with thyroid dysfunction were assessed periodically or treated depending on the severity. Subjects were followed until delivery. Results. The prevalence of hypothyroidism, Graves' disease, gestational transient thyrotoxicosis, and thyroid autoimmunity (TAI) was 4.8% (n = 24), 0.6% (n = 3), 6.4 % (n = 31), and 12.4% (n = 60), respectively. Forty percent of the hypothyroid patients did not have any high-risk characteristics. Hypothyroidism and TAI were associated with miscarriage (P = 0.02 and P = 0.001, resp.). Conclusions. The prevalence of hypothyroidism (4.8%) and TAI (12.4%) is high. TAI and hypothyroidism were significantly associated with miscarriage.

No MeSH data available.


Related in: MedlinePlus