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Pathology of epstein-barr virus-associated gastric carcinoma and its relationship to prognosis.

Song HJ, Kim KM - Gut Liver (2011)

Bottom Line: Among Epstein-Barr virus (EBV)-associated neoplasms, EBV-associated gastric carcinoma (EBVaGC) is the most common tumor worldwide.Recent studies have shown that patients with the lymphoepithelioma-like carcinoma subtype of EBVaGC have the best overall and disease-free survival, followed by Crohn's disease-like reactions, which in turn have better survival than patients with conventional-type adenocarcinoma.Histologic subclassifications of EBVaGCs are based on the differing degree and pattern of infl ammatory response and the extent of desmoplasia.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Among Epstein-Barr virus (EBV)-associated neoplasms, EBV-associated gastric carcinoma (EBVaGC) is the most common tumor worldwide. In contrast to the predominant site of occurrence of EBV-negative gastric carcinoma in the antrum, EBVaGC occurs most frequently in the proximal stomach, including the cardia, fundus and body. Microscopically, EBVaGC can be subclassified into three histological subtypes according to the host cellular immune responses: lymphoepithelioma-like carcinoma, carcinoma with Crohn's disease-like lymphoid reaction, and conventional-type adenocarcinoma. Recent studies have shown that patients with the lymphoepithelioma-like carcinoma subtype of EBVaGC have the best overall and disease-free survival, followed by Crohn's disease-like reactions, which in turn have better survival than patients with conventional-type adenocarcinoma. Histologic subclassifications of EBVaGCs are based on the differing degree and pattern of infl ammatory response and the extent of desmoplasia. Because these subclassifications appear to be a powerful prognostic parameter, further research into the underlying mechanisms of the cellular immune reaction in these pathologic subtypes of EBVaGCs may play a key role in understanding the innate immune response of patients with this highly aggressive carcinoma.

No MeSH data available.


Related in: MedlinePlus

Carcinoma with Crohn's disease-like lymphoid reaction (H&E stain, ×4). Well-formed lymphoid follicles are easily found, but the tumor margin is somewhat infiltrative and tumor cells outnumber lymphocytes.
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Figure 3: Carcinoma with Crohn's disease-like lymphoid reaction (H&E stain, ×4). Well-formed lymphoid follicles are easily found, but the tumor margin is somewhat infiltrative and tumor cells outnumber lymphocytes.

Mentions: Carcinoma with Crohn's disease-like lymphoid reaction (CLR) was defined by 1) patchy lymphocytic infiltration with 3 or more lymphoid follicles with active germinal centers per tissue section at the advancing edge of the tumor, 2) smaller numbers of lymphocytes than tumor cells, 3) frequent tubule or gland formation, and 4) minimal or no desmoplasia (Fig. 3). In this pathologic subtype, it is characteristic that desmoplastic reaction is less prominent than conventional-type adenocarcinoma, especially of diffuse-type.


Pathology of epstein-barr virus-associated gastric carcinoma and its relationship to prognosis.

Song HJ, Kim KM - Gut Liver (2011)

Carcinoma with Crohn's disease-like lymphoid reaction (H&E stain, ×4). Well-formed lymphoid follicles are easily found, but the tumor margin is somewhat infiltrative and tumor cells outnumber lymphocytes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3140657&req=5

Figure 3: Carcinoma with Crohn's disease-like lymphoid reaction (H&E stain, ×4). Well-formed lymphoid follicles are easily found, but the tumor margin is somewhat infiltrative and tumor cells outnumber lymphocytes.
Mentions: Carcinoma with Crohn's disease-like lymphoid reaction (CLR) was defined by 1) patchy lymphocytic infiltration with 3 or more lymphoid follicles with active germinal centers per tissue section at the advancing edge of the tumor, 2) smaller numbers of lymphocytes than tumor cells, 3) frequent tubule or gland formation, and 4) minimal or no desmoplasia (Fig. 3). In this pathologic subtype, it is characteristic that desmoplastic reaction is less prominent than conventional-type adenocarcinoma, especially of diffuse-type.

Bottom Line: Among Epstein-Barr virus (EBV)-associated neoplasms, EBV-associated gastric carcinoma (EBVaGC) is the most common tumor worldwide.Recent studies have shown that patients with the lymphoepithelioma-like carcinoma subtype of EBVaGC have the best overall and disease-free survival, followed by Crohn's disease-like reactions, which in turn have better survival than patients with conventional-type adenocarcinoma.Histologic subclassifications of EBVaGCs are based on the differing degree and pattern of infl ammatory response and the extent of desmoplasia.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Among Epstein-Barr virus (EBV)-associated neoplasms, EBV-associated gastric carcinoma (EBVaGC) is the most common tumor worldwide. In contrast to the predominant site of occurrence of EBV-negative gastric carcinoma in the antrum, EBVaGC occurs most frequently in the proximal stomach, including the cardia, fundus and body. Microscopically, EBVaGC can be subclassified into three histological subtypes according to the host cellular immune responses: lymphoepithelioma-like carcinoma, carcinoma with Crohn's disease-like lymphoid reaction, and conventional-type adenocarcinoma. Recent studies have shown that patients with the lymphoepithelioma-like carcinoma subtype of EBVaGC have the best overall and disease-free survival, followed by Crohn's disease-like reactions, which in turn have better survival than patients with conventional-type adenocarcinoma. Histologic subclassifications of EBVaGCs are based on the differing degree and pattern of infl ammatory response and the extent of desmoplasia. Because these subclassifications appear to be a powerful prognostic parameter, further research into the underlying mechanisms of the cellular immune reaction in these pathologic subtypes of EBVaGCs may play a key role in understanding the innate immune response of patients with this highly aggressive carcinoma.

No MeSH data available.


Related in: MedlinePlus