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Pathology of epstein-barr virus-associated gastric carcinoma and its relationship to prognosis.

Song HJ, Kim KM - Gut Liver (2011)

Bottom Line: Among Epstein-Barr virus (EBV)-associated neoplasms, EBV-associated gastric carcinoma (EBVaGC) is the most common tumor worldwide.Recent studies have shown that patients with the lymphoepithelioma-like carcinoma subtype of EBVaGC have the best overall and disease-free survival, followed by Crohn's disease-like reactions, which in turn have better survival than patients with conventional-type adenocarcinoma.Histologic subclassifications of EBVaGCs are based on the differing degree and pattern of infl ammatory response and the extent of desmoplasia.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Among Epstein-Barr virus (EBV)-associated neoplasms, EBV-associated gastric carcinoma (EBVaGC) is the most common tumor worldwide. In contrast to the predominant site of occurrence of EBV-negative gastric carcinoma in the antrum, EBVaGC occurs most frequently in the proximal stomach, including the cardia, fundus and body. Microscopically, EBVaGC can be subclassified into three histological subtypes according to the host cellular immune responses: lymphoepithelioma-like carcinoma, carcinoma with Crohn's disease-like lymphoid reaction, and conventional-type adenocarcinoma. Recent studies have shown that patients with the lymphoepithelioma-like carcinoma subtype of EBVaGC have the best overall and disease-free survival, followed by Crohn's disease-like reactions, which in turn have better survival than patients with conventional-type adenocarcinoma. Histologic subclassifications of EBVaGCs are based on the differing degree and pattern of infl ammatory response and the extent of desmoplasia. Because these subclassifications appear to be a powerful prognostic parameter, further research into the underlying mechanisms of the cellular immune reaction in these pathologic subtypes of EBVaGCs may play a key role in understanding the innate immune response of patients with this highly aggressive carcinoma.

No MeSH data available.


Related in: MedlinePlus

(A) Tumor cells show a 'lace pattern,' the connection and fusion of neoplastic glands (H&E stain, ×10). (B) In situ hybridization for Epstein-Barr virus-encoded RNA in early gastric carcinoma (×10).
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Figure 2: (A) Tumor cells show a 'lace pattern,' the connection and fusion of neoplastic glands (H&E stain, ×10). (B) In situ hybridization for Epstein-Barr virus-encoded RNA in early gastric carcinoma (×10).

Mentions: Typical microscopic findings of LELC are defined by 1) well-defined tumor margin, 2) dense lymphocytic infiltration of a degree whereby the number of tumor infiltrating lymphocytes was greater than the tumor cells throughout the tumor, 3) indistinct cytoplasmic borders and a syncytial growth pattern with poorly formed glandular structures, and 4) no desmoplasia (Fig. 1).14 Particularly, in the intramucosal stage, LELC shows a 'lace pattern' which consists of the connection and fusion of neoplastic glands (Fig. 2).23


Pathology of epstein-barr virus-associated gastric carcinoma and its relationship to prognosis.

Song HJ, Kim KM - Gut Liver (2011)

(A) Tumor cells show a 'lace pattern,' the connection and fusion of neoplastic glands (H&E stain, ×10). (B) In situ hybridization for Epstein-Barr virus-encoded RNA in early gastric carcinoma (×10).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3140657&req=5

Figure 2: (A) Tumor cells show a 'lace pattern,' the connection and fusion of neoplastic glands (H&E stain, ×10). (B) In situ hybridization for Epstein-Barr virus-encoded RNA in early gastric carcinoma (×10).
Mentions: Typical microscopic findings of LELC are defined by 1) well-defined tumor margin, 2) dense lymphocytic infiltration of a degree whereby the number of tumor infiltrating lymphocytes was greater than the tumor cells throughout the tumor, 3) indistinct cytoplasmic borders and a syncytial growth pattern with poorly formed glandular structures, and 4) no desmoplasia (Fig. 1).14 Particularly, in the intramucosal stage, LELC shows a 'lace pattern' which consists of the connection and fusion of neoplastic glands (Fig. 2).23

Bottom Line: Among Epstein-Barr virus (EBV)-associated neoplasms, EBV-associated gastric carcinoma (EBVaGC) is the most common tumor worldwide.Recent studies have shown that patients with the lymphoepithelioma-like carcinoma subtype of EBVaGC have the best overall and disease-free survival, followed by Crohn's disease-like reactions, which in turn have better survival than patients with conventional-type adenocarcinoma.Histologic subclassifications of EBVaGCs are based on the differing degree and pattern of infl ammatory response and the extent of desmoplasia.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Among Epstein-Barr virus (EBV)-associated neoplasms, EBV-associated gastric carcinoma (EBVaGC) is the most common tumor worldwide. In contrast to the predominant site of occurrence of EBV-negative gastric carcinoma in the antrum, EBVaGC occurs most frequently in the proximal stomach, including the cardia, fundus and body. Microscopically, EBVaGC can be subclassified into three histological subtypes according to the host cellular immune responses: lymphoepithelioma-like carcinoma, carcinoma with Crohn's disease-like lymphoid reaction, and conventional-type adenocarcinoma. Recent studies have shown that patients with the lymphoepithelioma-like carcinoma subtype of EBVaGC have the best overall and disease-free survival, followed by Crohn's disease-like reactions, which in turn have better survival than patients with conventional-type adenocarcinoma. Histologic subclassifications of EBVaGCs are based on the differing degree and pattern of infl ammatory response and the extent of desmoplasia. Because these subclassifications appear to be a powerful prognostic parameter, further research into the underlying mechanisms of the cellular immune reaction in these pathologic subtypes of EBVaGCs may play a key role in understanding the innate immune response of patients with this highly aggressive carcinoma.

No MeSH data available.


Related in: MedlinePlus