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Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters.

Mahdi ES, Sakeena MH, Abdulkarim MF, Abdullah GZ, Sattar MA, Noor AM - Drug Des Devel Ther (2011)

Bottom Line: High solubilization capacity was obtained by Tween(®) 80 compared with other surfactants of Tween(®) series.High HLB blends of Tween(®) 80/Span(®) 85 and Tween(®) 80/Span(®) 80 at HLB 13.7 and 13.9, respectively, have better solubilization capacity compared with the lower HLB values of Tween(®) 80/Span(®) 80.The use of palm kernel oil esters can improve drug delivery and reduce the cost of cosmetics.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia.

ABSTRACT

Background: The purpose of this study was to select appropriate surfactants or blends of surfactants to study the ternary phase diagram behavior of newly introduced palm kernel oil esters.

Methods: Nonionic surfactant blends of Tween(®) and Tween(®)/Span(®) series were screened based on their solubilization capacity with water for palm kernel oil esters. Tween(®) 80 and five blends of Tween(®) 80/Span(®) 80 and Tween(®) 80/Span(®) 85 in the hydrophilic-lipophilic balance (HLB) value range of 10.7-14.0 were selected to study the phase diagram behavior of palm kernel oil esters using the water titration method at room temperature.

Results: High solubilization capacity was obtained by Tween(®) 80 compared with other surfactants of Tween(®) series. High HLB blends of Tween(®) 80/Span(®) 85 and Tween(®) 80/Span(®) 80 at HLB 13.7 and 13.9, respectively, have better solubilization capacity compared with the lower HLB values of Tween(®) 80/Span(®) 80. All the selected blends of surfactants were formed as water-in-oil microemulsions, and other dispersion systems varied in size and geometrical layout in the triangles. The high solubilization capacity and larger areas of the water-in-oil microemulsion systems were due to the structural similarity between the lipophilic tail of Tween(®) 80 and the oleyl group of the palm kernel oil esters.

Conclusion: This study suggests that the phase diagram behavior of palm kernel oil esters, water, and nonionic surfactants is not only affected by the HLB value, but also by the structural similarity between palm kernel oil esters and the surfactant used. The information gathered in this study is useful for researchers and manufacturers interested in using palm kernel oil esters in pharmaceutical and cosmetic preparation. The use of palm kernel oil esters can improve drug delivery and reduce the cost of cosmetics.

Show MeSH
Complete schematic pseudoternary phase formed by Tween® 80/Span® 85 blend at HLB 13.7, palm kernel oil esters and water at various component compositions.Abbreviations: HLB, hydrophilic-lipophilic balance; PKOEs, palm kernel oil esters; W/O, water-in-oil; EMG, emollient gel; ME, microemulsion; O/W, oil-in-water; LC, liquid crystalline; Surfact, surfactant; T, Tween®; S, Span®.
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f7-dddt-5-311: Complete schematic pseudoternary phase formed by Tween® 80/Span® 85 blend at HLB 13.7, palm kernel oil esters and water at various component compositions.Abbreviations: HLB, hydrophilic-lipophilic balance; PKOEs, palm kernel oil esters; W/O, water-in-oil; EMG, emollient gel; ME, microemulsion; O/W, oil-in-water; LC, liquid crystalline; Surfact, surfactant; T, Tween®; S, Span®.

Mentions: Figure 7 shows the phase diagram behavior of a Tween® 80/Span® 85 blend at HLB 13.7. This blend of surfactants results in a phase diagram with features similar to those of the Tween® 80 phase diagram. The major differences are the larger area of water-in-oil organogel and the smaller area of oil-in-water organogel, in addition to the formation of a water-in-oil liquid crystalline dispersion system which is completely absent in the phase diagram of Tween® 80. The formation of this type of dispersion system in the blends of surfactants (Tween® 80/Span® 85) indicates better coverage of Tween® 80/Span® 85 at the interface, leading to the formation of a stable and identified water-in-oil liquid crystalline system in the presence of a hydrophilic-lipophilic blend of surfactants. This result shows the importance of not only the optimal HLB of the blend but also the type of surfactants in the blend.


Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters.

Mahdi ES, Sakeena MH, Abdulkarim MF, Abdullah GZ, Sattar MA, Noor AM - Drug Des Devel Ther (2011)

Complete schematic pseudoternary phase formed by Tween® 80/Span® 85 blend at HLB 13.7, palm kernel oil esters and water at various component compositions.Abbreviations: HLB, hydrophilic-lipophilic balance; PKOEs, palm kernel oil esters; W/O, water-in-oil; EMG, emollient gel; ME, microemulsion; O/W, oil-in-water; LC, liquid crystalline; Surfact, surfactant; T, Tween®; S, Span®.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3140288&req=5

f7-dddt-5-311: Complete schematic pseudoternary phase formed by Tween® 80/Span® 85 blend at HLB 13.7, palm kernel oil esters and water at various component compositions.Abbreviations: HLB, hydrophilic-lipophilic balance; PKOEs, palm kernel oil esters; W/O, water-in-oil; EMG, emollient gel; ME, microemulsion; O/W, oil-in-water; LC, liquid crystalline; Surfact, surfactant; T, Tween®; S, Span®.
Mentions: Figure 7 shows the phase diagram behavior of a Tween® 80/Span® 85 blend at HLB 13.7. This blend of surfactants results in a phase diagram with features similar to those of the Tween® 80 phase diagram. The major differences are the larger area of water-in-oil organogel and the smaller area of oil-in-water organogel, in addition to the formation of a water-in-oil liquid crystalline dispersion system which is completely absent in the phase diagram of Tween® 80. The formation of this type of dispersion system in the blends of surfactants (Tween® 80/Span® 85) indicates better coverage of Tween® 80/Span® 85 at the interface, leading to the formation of a stable and identified water-in-oil liquid crystalline system in the presence of a hydrophilic-lipophilic blend of surfactants. This result shows the importance of not only the optimal HLB of the blend but also the type of surfactants in the blend.

Bottom Line: High solubilization capacity was obtained by Tween(®) 80 compared with other surfactants of Tween(®) series.High HLB blends of Tween(®) 80/Span(®) 85 and Tween(®) 80/Span(®) 80 at HLB 13.7 and 13.9, respectively, have better solubilization capacity compared with the lower HLB values of Tween(®) 80/Span(®) 80.The use of palm kernel oil esters can improve drug delivery and reduce the cost of cosmetics.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia.

ABSTRACT

Background: The purpose of this study was to select appropriate surfactants or blends of surfactants to study the ternary phase diagram behavior of newly introduced palm kernel oil esters.

Methods: Nonionic surfactant blends of Tween(®) and Tween(®)/Span(®) series were screened based on their solubilization capacity with water for palm kernel oil esters. Tween(®) 80 and five blends of Tween(®) 80/Span(®) 80 and Tween(®) 80/Span(®) 85 in the hydrophilic-lipophilic balance (HLB) value range of 10.7-14.0 were selected to study the phase diagram behavior of palm kernel oil esters using the water titration method at room temperature.

Results: High solubilization capacity was obtained by Tween(®) 80 compared with other surfactants of Tween(®) series. High HLB blends of Tween(®) 80/Span(®) 85 and Tween(®) 80/Span(®) 80 at HLB 13.7 and 13.9, respectively, have better solubilization capacity compared with the lower HLB values of Tween(®) 80/Span(®) 80. All the selected blends of surfactants were formed as water-in-oil microemulsions, and other dispersion systems varied in size and geometrical layout in the triangles. The high solubilization capacity and larger areas of the water-in-oil microemulsion systems were due to the structural similarity between the lipophilic tail of Tween(®) 80 and the oleyl group of the palm kernel oil esters.

Conclusion: This study suggests that the phase diagram behavior of palm kernel oil esters, water, and nonionic surfactants is not only affected by the HLB value, but also by the structural similarity between palm kernel oil esters and the surfactant used. The information gathered in this study is useful for researchers and manufacturers interested in using palm kernel oil esters in pharmaceutical and cosmetic preparation. The use of palm kernel oil esters can improve drug delivery and reduce the cost of cosmetics.

Show MeSH