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Human Papillomavirus and Oropharyngeal Squamous Cell Carcinoma: A Case-Control Study regarding Tobacco and Alcohol Consumption.

Farshadpour F, Konings S, Speel EJ, Hordijk GJ, Koole R, van Blokland M, Slootweg PJ, Kummer JA - Patholog Res Int (2011)

Bottom Line: Overall survival and disease-specific survival were higher for HPV-positive compared to HPV-negative cases (P = 0.027, P = 0.039, resp.).In conclusion, HPV is strongly associated with OSCC of nonsmoking and nondrinking patients.Specific diagnostic and therapeutic actions should be considered for these patients to achieve a better prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.

ABSTRACT
We aimed to determine the role of HPV in the pathogenesis and outcome of oropharyngeal squamous cell carcinoma (OSCC) in lifelong nonsmoking and nondrinking patients. A case-case analysis was performed to compare the presence of HPV-DNA in tumor cells of 16 nonsmoking and nondrinking with 16 matched smoking and drinking patients (matching criteria: age at incidence, gender, tumor sublocation, tumor stage). HPV was detected using 2 PCR tests, FISH analysis, and p16(INK4A) immunostaining. Nonsmoking and nondrinking patients had more HPV-positive tumors than smoking and drinking patients (n = 12; 75% versus n = 2; 13%; P < 0.001). All HPV-positive tumors showed p16(INK4A) overexpression, and 1 HPV-negative tumor had p16(INK4A) overexpression, (P < 0.001). Overall survival and disease-specific survival were higher for HPV-positive compared to HPV-negative cases (P = 0.027, P = 0.039, resp.). In conclusion, HPV is strongly associated with OSCC of nonsmoking and nondrinking patients. Specific diagnostic and therapeutic actions should be considered for these patients to achieve a better prognosis.

No MeSH data available.


Related in: MedlinePlus

(a) Overall survival for HPV-positive compared to HPV-negative cases. (b) Disease-specific survival for HPV-positive compared to HPV-negative cases.
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Related In: Results  -  Collection


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fig1: (a) Overall survival for HPV-positive compared to HPV-negative cases. (b) Disease-specific survival for HPV-positive compared to HPV-negative cases.

Mentions: Follow-up time ranged from 5.9 to 182.1 months. Median follow-up time was 61.1 months. The 5-year overall and disease-specific survival for all cases was 53% and 64%, respectively. Cause of death in 20 deceased patients was as follows: due to primary tumor (n = 4; 1 nonsmoking and nondrinking, 3 smoking and drinking), other causes (n = 7; 4 nonsmoking and nondrinking, 3 smoking and drinking) of which 5 cardial and 2 pulmonary disease, recurrent disease (n = 6; 2 nonsmoking and nondrinking, 4 smoking and drinking), and second primary tumor (n = 3 smoking and drinking). For HPV-positive and HPV-negative cases, the 5-year overall survival was 71% and 42%, and 5-year disease-specific survival was 76% and 57%, respectively. Overall and disease-specific survival were both significantly higher for HPV-positive compared to HPV-negative cases (P = 0.027, P = 0.039, resp., Figure 1), for nonsmoking and nondrinking patients compared to the smoking and drinking counterparts (P = 0.037, P = 0.013, resp.) and for cases with p16INK4A overexpression compared to those without detectable p16INK4A overexpression (P = 0.028, P = 0.030, resp.).


Human Papillomavirus and Oropharyngeal Squamous Cell Carcinoma: A Case-Control Study regarding Tobacco and Alcohol Consumption.

Farshadpour F, Konings S, Speel EJ, Hordijk GJ, Koole R, van Blokland M, Slootweg PJ, Kummer JA - Patholog Res Int (2011)

(a) Overall survival for HPV-positive compared to HPV-negative cases. (b) Disease-specific survival for HPV-positive compared to HPV-negative cases.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3140281&req=5

fig1: (a) Overall survival for HPV-positive compared to HPV-negative cases. (b) Disease-specific survival for HPV-positive compared to HPV-negative cases.
Mentions: Follow-up time ranged from 5.9 to 182.1 months. Median follow-up time was 61.1 months. The 5-year overall and disease-specific survival for all cases was 53% and 64%, respectively. Cause of death in 20 deceased patients was as follows: due to primary tumor (n = 4; 1 nonsmoking and nondrinking, 3 smoking and drinking), other causes (n = 7; 4 nonsmoking and nondrinking, 3 smoking and drinking) of which 5 cardial and 2 pulmonary disease, recurrent disease (n = 6; 2 nonsmoking and nondrinking, 4 smoking and drinking), and second primary tumor (n = 3 smoking and drinking). For HPV-positive and HPV-negative cases, the 5-year overall survival was 71% and 42%, and 5-year disease-specific survival was 76% and 57%, respectively. Overall and disease-specific survival were both significantly higher for HPV-positive compared to HPV-negative cases (P = 0.027, P = 0.039, resp., Figure 1), for nonsmoking and nondrinking patients compared to the smoking and drinking counterparts (P = 0.037, P = 0.013, resp.) and for cases with p16INK4A overexpression compared to those without detectable p16INK4A overexpression (P = 0.028, P = 0.030, resp.).

Bottom Line: Overall survival and disease-specific survival were higher for HPV-positive compared to HPV-negative cases (P = 0.027, P = 0.039, resp.).In conclusion, HPV is strongly associated with OSCC of nonsmoking and nondrinking patients.Specific diagnostic and therapeutic actions should be considered for these patients to achieve a better prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.

ABSTRACT
We aimed to determine the role of HPV in the pathogenesis and outcome of oropharyngeal squamous cell carcinoma (OSCC) in lifelong nonsmoking and nondrinking patients. A case-case analysis was performed to compare the presence of HPV-DNA in tumor cells of 16 nonsmoking and nondrinking with 16 matched smoking and drinking patients (matching criteria: age at incidence, gender, tumor sublocation, tumor stage). HPV was detected using 2 PCR tests, FISH analysis, and p16(INK4A) immunostaining. Nonsmoking and nondrinking patients had more HPV-positive tumors than smoking and drinking patients (n = 12; 75% versus n = 2; 13%; P < 0.001). All HPV-positive tumors showed p16(INK4A) overexpression, and 1 HPV-negative tumor had p16(INK4A) overexpression, (P < 0.001). Overall survival and disease-specific survival were higher for HPV-positive compared to HPV-negative cases (P = 0.027, P = 0.039, resp.). In conclusion, HPV is strongly associated with OSCC of nonsmoking and nondrinking patients. Specific diagnostic and therapeutic actions should be considered for these patients to achieve a better prognosis.

No MeSH data available.


Related in: MedlinePlus