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Post-kala-azar dermal leishmaniasis in HIV-positive patients: A study of two cases.

Shah S, Shah A, Prajapati S, Bilimoria F - Indian J Sex Transm Dis (2010)

Bottom Line: Cutaneous leishmaniasis and human immunodeficiency virus (HIV) co-infection is emerging as increasingly frequent and serious new disease.We describe two cases of post-kala-azar dermal leishmaniasis in HIV-positive patients.Slit skin smear with giemsa stain revealed Leishman Donovan (LD) bodies and skin biopsy of both the patients revealed lymphohistiocytic infiltrate with numerous intracytoplasmic LD bodies.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology and Venerology, SBKS Medical College and Research Centre, Pipariya, Waghodia, Gujarat, India.

ABSTRACT
Cutaneous leishmaniasis and human immunodeficiency virus (HIV) co-infection is emerging as increasingly frequent and serious new disease. Leishmaniasis may be acquired before or after HIV infection. We describe two cases of post-kala-azar dermal leishmaniasis in HIV-positive patients. Both the patients had papulonodular lesions on upper extremities and back with low CD4 count. Slit skin smear with giemsa stain revealed Leishman Donovan (LD) bodies and skin biopsy of both the patients revealed lymphohistiocytic infiltrate with numerous intracytoplasmic LD bodies.

No MeSH data available.


Related in: MedlinePlus

H and E shows macrophages containing leishman donovan bodies
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Figure 0003: H and E shows macrophages containing leishman donovan bodies

Mentions: A 52-year-old HIV-positive man from Rajasthan presented with multiple papulonodular lesions mainly on dorsum of hand, forearm, thighs, and back for past 3 months [Figure 2]. Differential diagnosis of Hansen’s disease, sarcoidosis, and leishmaniasis were performed. Routine blood parameters were in normal limits. His CD4 count was 170/μL. Slit skin smear revealed multiple intra- and extracellular leishman donovan bodies with giemsa stain. Biopsy of lesion revealed mixed dermal lymphocytes and histiocytes showing intracellular leishman donovan bodies [Figure 3].


Post-kala-azar dermal leishmaniasis in HIV-positive patients: A study of two cases.

Shah S, Shah A, Prajapati S, Bilimoria F - Indian J Sex Transm Dis (2010)

H and E shows macrophages containing leishman donovan bodies
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3140149&req=5

Figure 0003: H and E shows macrophages containing leishman donovan bodies
Mentions: A 52-year-old HIV-positive man from Rajasthan presented with multiple papulonodular lesions mainly on dorsum of hand, forearm, thighs, and back for past 3 months [Figure 2]. Differential diagnosis of Hansen’s disease, sarcoidosis, and leishmaniasis were performed. Routine blood parameters were in normal limits. His CD4 count was 170/μL. Slit skin smear revealed multiple intra- and extracellular leishman donovan bodies with giemsa stain. Biopsy of lesion revealed mixed dermal lymphocytes and histiocytes showing intracellular leishman donovan bodies [Figure 3].

Bottom Line: Cutaneous leishmaniasis and human immunodeficiency virus (HIV) co-infection is emerging as increasingly frequent and serious new disease.We describe two cases of post-kala-azar dermal leishmaniasis in HIV-positive patients.Slit skin smear with giemsa stain revealed Leishman Donovan (LD) bodies and skin biopsy of both the patients revealed lymphohistiocytic infiltrate with numerous intracytoplasmic LD bodies.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology and Venerology, SBKS Medical College and Research Centre, Pipariya, Waghodia, Gujarat, India.

ABSTRACT
Cutaneous leishmaniasis and human immunodeficiency virus (HIV) co-infection is emerging as increasingly frequent and serious new disease. Leishmaniasis may be acquired before or after HIV infection. We describe two cases of post-kala-azar dermal leishmaniasis in HIV-positive patients. Both the patients had papulonodular lesions on upper extremities and back with low CD4 count. Slit skin smear with giemsa stain revealed Leishman Donovan (LD) bodies and skin biopsy of both the patients revealed lymphohistiocytic infiltrate with numerous intracytoplasmic LD bodies.

No MeSH data available.


Related in: MedlinePlus