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Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy.

Grima P, Zizza A, Guido M, Tundo P, Chiavaroli R - Indian J Sex Transm Dis (2010)

Bottom Line: The mean of PRFT and IARI in HIV-1-infected patients with visceral obesity was considerably higher than that in patients without it (P <0.001 and <0.01, respectively).Using the average IARI as the dependent variable, age (odds ratio, 1.07; 95% confidence interval [CI], 1.01-1.14; P < 0.5) and PRFT (odds ratio, 1.28; 95% CI, 1.08P-1.51; P<0.01) were independent factors associated with IARI.Our data indicate that ultrasonographic assessment of PRFT may have a potential to be a marker of increased endothelial damage with specific involvement of the renal vascular district in HIV-1-infected patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases, HIV Center, "S.Caterina Novella" Hospital, Galatina, Italy.

ABSTRACT

Purpose: The aim of our study was to evaluate whether perirenal fat thickness (PRFT), a parameter of central obesity, is related to kidney function and intrarenal artery resistive index (IARI) in human immunodeficiency virus (HIV)-1-infected patients.

Materials and methods: We enrolled 102 consecutive HIV-1-infected patients receiving highly active antiretroviral therapy for more than 12 months in a prospective cohort study. Echographically, the PRFT and IARI were measured and the serum metabolic parameters were evaluated. PRFT and IARI were measured using a 3.75 MHz convex linear probe.

Results: The mean of PRFT and IARI in HIV-1-infected patients with visceral obesity was considerably higher than that in patients without it (P <0.001 and <0.01, respectively). Using the average IARI as the dependent variable, age (odds ratio, 1.07; 95% confidence interval [CI], 1.01-1.14; P < 0.5) and PRFT (odds ratio, 1.28; 95% CI, 1.08P-1.51; P<0.01) were independent factors associated with IARI.

Conclusion: Our data indicate that ultrasonographic assessment of PRFT may have a potential to be a marker of increased endothelial damage with specific involvement of the renal vascular district in HIV-1-infected patients.

No MeSH data available.


Related in: MedlinePlus

Linear regression curve of relation between echographicmeasured perirenal fat thickness (PRFT) and creatinine clearance in 102 human immunodeficiency virus-1-infected patients. Dotted line, 95% confidence interval; PRFT, perirenal fat thickness
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Figure 0004: Linear regression curve of relation between echographicmeasured perirenal fat thickness (PRFT) and creatinine clearance in 102 human immunodeficiency virus-1-infected patients. Dotted line, 95% confidence interval; PRFT, perirenal fat thickness

Mentions: For all 102 HIV-1-infected patients, ultrasound-measured PRFT correlated well with IARI (r +0.35; P < 0.001) and with creatinine clearance (r -0.29; P < 0.01) [Figures 3 and 4].


Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy.

Grima P, Zizza A, Guido M, Tundo P, Chiavaroli R - Indian J Sex Transm Dis (2010)

Linear regression curve of relation between echographicmeasured perirenal fat thickness (PRFT) and creatinine clearance in 102 human immunodeficiency virus-1-infected patients. Dotted line, 95% confidence interval; PRFT, perirenal fat thickness
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3140143&req=5

Figure 0004: Linear regression curve of relation between echographicmeasured perirenal fat thickness (PRFT) and creatinine clearance in 102 human immunodeficiency virus-1-infected patients. Dotted line, 95% confidence interval; PRFT, perirenal fat thickness
Mentions: For all 102 HIV-1-infected patients, ultrasound-measured PRFT correlated well with IARI (r +0.35; P < 0.001) and with creatinine clearance (r -0.29; P < 0.01) [Figures 3 and 4].

Bottom Line: The mean of PRFT and IARI in HIV-1-infected patients with visceral obesity was considerably higher than that in patients without it (P <0.001 and <0.01, respectively).Using the average IARI as the dependent variable, age (odds ratio, 1.07; 95% confidence interval [CI], 1.01-1.14; P < 0.5) and PRFT (odds ratio, 1.28; 95% CI, 1.08P-1.51; P<0.01) were independent factors associated with IARI.Our data indicate that ultrasonographic assessment of PRFT may have a potential to be a marker of increased endothelial damage with specific involvement of the renal vascular district in HIV-1-infected patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases, HIV Center, "S.Caterina Novella" Hospital, Galatina, Italy.

ABSTRACT

Purpose: The aim of our study was to evaluate whether perirenal fat thickness (PRFT), a parameter of central obesity, is related to kidney function and intrarenal artery resistive index (IARI) in human immunodeficiency virus (HIV)-1-infected patients.

Materials and methods: We enrolled 102 consecutive HIV-1-infected patients receiving highly active antiretroviral therapy for more than 12 months in a prospective cohort study. Echographically, the PRFT and IARI were measured and the serum metabolic parameters were evaluated. PRFT and IARI were measured using a 3.75 MHz convex linear probe.

Results: The mean of PRFT and IARI in HIV-1-infected patients with visceral obesity was considerably higher than that in patients without it (P <0.001 and <0.01, respectively). Using the average IARI as the dependent variable, age (odds ratio, 1.07; 95% confidence interval [CI], 1.01-1.14; P < 0.5) and PRFT (odds ratio, 1.28; 95% CI, 1.08P-1.51; P<0.01) were independent factors associated with IARI.

Conclusion: Our data indicate that ultrasonographic assessment of PRFT may have a potential to be a marker of increased endothelial damage with specific involvement of the renal vascular district in HIV-1-infected patients.

No MeSH data available.


Related in: MedlinePlus