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Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy.

Grima P, Zizza A, Guido M, Tundo P, Chiavaroli R - Indian J Sex Transm Dis (2010)

Bottom Line: The mean of PRFT and IARI in HIV-1-infected patients with visceral obesity was considerably higher than that in patients without it (P <0.001 and <0.01, respectively).Using the average IARI as the dependent variable, age (odds ratio, 1.07; 95% confidence interval [CI], 1.01-1.14; P < 0.5) and PRFT (odds ratio, 1.28; 95% CI, 1.08P-1.51; P<0.01) were independent factors associated with IARI.Our data indicate that ultrasonographic assessment of PRFT may have a potential to be a marker of increased endothelial damage with specific involvement of the renal vascular district in HIV-1-infected patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases, HIV Center, "S.Caterina Novella" Hospital, Galatina, Italy.

ABSTRACT

Purpose: The aim of our study was to evaluate whether perirenal fat thickness (PRFT), a parameter of central obesity, is related to kidney function and intrarenal artery resistive index (IARI) in human immunodeficiency virus (HIV)-1-infected patients.

Materials and methods: We enrolled 102 consecutive HIV-1-infected patients receiving highly active antiretroviral therapy for more than 12 months in a prospective cohort study. Echographically, the PRFT and IARI were measured and the serum metabolic parameters were evaluated. PRFT and IARI were measured using a 3.75 MHz convex linear probe.

Results: The mean of PRFT and IARI in HIV-1-infected patients with visceral obesity was considerably higher than that in patients without it (P <0.001 and <0.01, respectively). Using the average IARI as the dependent variable, age (odds ratio, 1.07; 95% confidence interval [CI], 1.01-1.14; P < 0.5) and PRFT (odds ratio, 1.28; 95% CI, 1.08P-1.51; P<0.01) were independent factors associated with IARI.

Conclusion: Our data indicate that ultrasonographic assessment of PRFT may have a potential to be a marker of increased endothelial damage with specific involvement of the renal vascular district in HIV-1-infected patients.

No MeSH data available.


Related in: MedlinePlus

Assessment of perirenal fat diameter. Longitudinal scan (3.75 mHz) along the right midclavicular line, from the border of the right liver lobe to the border of the inferior pole of the right kidney. Arrows, limits of perirenal fat thickness
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Figure 0001: Assessment of perirenal fat diameter. Longitudinal scan (3.75 mHz) along the right midclavicular line, from the border of the right liver lobe to the border of the inferior pole of the right kidney. Arrows, limits of perirenal fat thickness

Mentions: A Logiq 5 ultrasound scanner (General Electrics Medical Systems, CT, USA) equipped with a 3.75 MHz convex probe was employed. The visceral fat thickness was determined with a 3.75-MHz convex transducer at a specific referee point as PRFT (longitudinal scan along the right mid clavicular line, from the border of the right liver lobe to the border of the inferior pole of the right kidney [Figure 1]), with the patient in the supine position. IARI was measured with the patient lying supine, using an ultrasound frequency of 3.75 mHz. In each kidney, intrarenal Doppler spectra were obtained atthree representative locations from the interlobar arteriesalong the border of the medullary pyramids. The resistive index(RI) was calculated according to the following formula:


Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy.

Grima P, Zizza A, Guido M, Tundo P, Chiavaroli R - Indian J Sex Transm Dis (2010)

Assessment of perirenal fat diameter. Longitudinal scan (3.75 mHz) along the right midclavicular line, from the border of the right liver lobe to the border of the inferior pole of the right kidney. Arrows, limits of perirenal fat thickness
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3140143&req=5

Figure 0001: Assessment of perirenal fat diameter. Longitudinal scan (3.75 mHz) along the right midclavicular line, from the border of the right liver lobe to the border of the inferior pole of the right kidney. Arrows, limits of perirenal fat thickness
Mentions: A Logiq 5 ultrasound scanner (General Electrics Medical Systems, CT, USA) equipped with a 3.75 MHz convex probe was employed. The visceral fat thickness was determined with a 3.75-MHz convex transducer at a specific referee point as PRFT (longitudinal scan along the right mid clavicular line, from the border of the right liver lobe to the border of the inferior pole of the right kidney [Figure 1]), with the patient in the supine position. IARI was measured with the patient lying supine, using an ultrasound frequency of 3.75 mHz. In each kidney, intrarenal Doppler spectra were obtained atthree representative locations from the interlobar arteriesalong the border of the medullary pyramids. The resistive index(RI) was calculated according to the following formula:

Bottom Line: The mean of PRFT and IARI in HIV-1-infected patients with visceral obesity was considerably higher than that in patients without it (P <0.001 and <0.01, respectively).Using the average IARI as the dependent variable, age (odds ratio, 1.07; 95% confidence interval [CI], 1.01-1.14; P < 0.5) and PRFT (odds ratio, 1.28; 95% CI, 1.08P-1.51; P<0.01) were independent factors associated with IARI.Our data indicate that ultrasonographic assessment of PRFT may have a potential to be a marker of increased endothelial damage with specific involvement of the renal vascular district in HIV-1-infected patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases, HIV Center, "S.Caterina Novella" Hospital, Galatina, Italy.

ABSTRACT

Purpose: The aim of our study was to evaluate whether perirenal fat thickness (PRFT), a parameter of central obesity, is related to kidney function and intrarenal artery resistive index (IARI) in human immunodeficiency virus (HIV)-1-infected patients.

Materials and methods: We enrolled 102 consecutive HIV-1-infected patients receiving highly active antiretroviral therapy for more than 12 months in a prospective cohort study. Echographically, the PRFT and IARI were measured and the serum metabolic parameters were evaluated. PRFT and IARI were measured using a 3.75 MHz convex linear probe.

Results: The mean of PRFT and IARI in HIV-1-infected patients with visceral obesity was considerably higher than that in patients without it (P <0.001 and <0.01, respectively). Using the average IARI as the dependent variable, age (odds ratio, 1.07; 95% confidence interval [CI], 1.01-1.14; P < 0.5) and PRFT (odds ratio, 1.28; 95% CI, 1.08P-1.51; P<0.01) were independent factors associated with IARI.

Conclusion: Our data indicate that ultrasonographic assessment of PRFT may have a potential to be a marker of increased endothelial damage with specific involvement of the renal vascular district in HIV-1-infected patients.

No MeSH data available.


Related in: MedlinePlus