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Bronchodilator activity of aqueous extract of stem bark of Ailanthus excelsa Roxb.

Kumar D, Bhujbal SS, Deoda RS, Mudgade SC - Pharmacognosy Res (2010)

Bottom Line: Stem bark of A. excelsa Roxb. has been used as a decoction in traditional claims.So, our traditional claims enforced us to evaluate its bronchodilator activity.The aqueous extract of stem bark in doses of 100, 200, 400 mg/kg showed significant activity.

View Article: PubMed Central - PubMed

Affiliation: Rayat Institute of Pharmacy, Railmajra, S.B.S. Nagar, Punjab, India.

ABSTRACT
Biologically active compounds from natural sources are of interest as possible new drugs for infectious diseases. Ailanthus excelsa Roxb. has been used in Indian system of medicine in the treatment of asthma, bronchitis, cold, colic pain, etc. Stem bark of A. excelsa Roxb. has been used as a decoction in traditional claims. So, our traditional claims enforced us to evaluate its bronchodilator activity. We have evaluated its bronchodilator activity in milk-induced leukocytosis and eosinophilia, clonidine-induced mast cell degranulation, bronchoalveolar lavage fluid (BALF), and lung histopathology models. The aqueous extract of stem bark in doses of 100, 200, 400 mg/kg showed significant activity.

No MeSH data available.


Related in: MedlinePlus

Effect of AESAq on milk-induced eosinophilia in mice (n = 5). Values are expressed in mean ± SEM. Control = vehicle (10 ml/kg p.o.); Intox. = milk 4 ml/kg; AESAq 100 = A. excelsa Roxb. stem bark aqueous extract (100 mg/kg p.o.); AESAq 200 = A. excelsa Roxb. stem bark aqueous extract (200 mg/kg p.o); AESAq 400 = A. excelsa Roxb. stem bark aqueous extract (400 mg/kg p.o.). Intox. group compared with control group using student's-t, test (***P < 0.001) and AESM is compared to intox. group using statistical analysis done by ANOVA followed by Dunnet's test (**P < 0.05,**P < 0.01)
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Figure 2: Effect of AESAq on milk-induced eosinophilia in mice (n = 5). Values are expressed in mean ± SEM. Control = vehicle (10 ml/kg p.o.); Intox. = milk 4 ml/kg; AESAq 100 = A. excelsa Roxb. stem bark aqueous extract (100 mg/kg p.o.); AESAq 200 = A. excelsa Roxb. stem bark aqueous extract (200 mg/kg p.o); AESAq 400 = A. excelsa Roxb. stem bark aqueous extract (400 mg/kg p.o.). Intox. group compared with control group using student's-t, test (***P < 0.001) and AESM is compared to intox. group using statistical analysis done by ANOVA followed by Dunnet's test (**P < 0.05,**P < 0.01)

Mentions: Subcutaneous injection of milk at a dose of 4 ml/kg produced a significant (***P < 0.001) increase in the leukocyte and total eosinophil count, 24 h after its administration. In the groups of mice pretreated with aqueous extract of A. excelsa Roxb. at doses of 100, 200 and 400 mg/kg p.o., there was significant (**P < 0.01) inhibition of milk-induced leukocytosis at 200 and 400 mg/kg p.o. doses, and in milk-induced eosinophilia, there was significant (*P < 0.05,**P < 0.01) inhibition of milk-induced eosinophilia at all the three doses [Figures 1 and 2].


Bronchodilator activity of aqueous extract of stem bark of Ailanthus excelsa Roxb.

Kumar D, Bhujbal SS, Deoda RS, Mudgade SC - Pharmacognosy Res (2010)

Effect of AESAq on milk-induced eosinophilia in mice (n = 5). Values are expressed in mean ± SEM. Control = vehicle (10 ml/kg p.o.); Intox. = milk 4 ml/kg; AESAq 100 = A. excelsa Roxb. stem bark aqueous extract (100 mg/kg p.o.); AESAq 200 = A. excelsa Roxb. stem bark aqueous extract (200 mg/kg p.o); AESAq 400 = A. excelsa Roxb. stem bark aqueous extract (400 mg/kg p.o.). Intox. group compared with control group using student's-t, test (***P < 0.001) and AESM is compared to intox. group using statistical analysis done by ANOVA followed by Dunnet's test (**P < 0.05,**P < 0.01)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3140105&req=5

Figure 2: Effect of AESAq on milk-induced eosinophilia in mice (n = 5). Values are expressed in mean ± SEM. Control = vehicle (10 ml/kg p.o.); Intox. = milk 4 ml/kg; AESAq 100 = A. excelsa Roxb. stem bark aqueous extract (100 mg/kg p.o.); AESAq 200 = A. excelsa Roxb. stem bark aqueous extract (200 mg/kg p.o); AESAq 400 = A. excelsa Roxb. stem bark aqueous extract (400 mg/kg p.o.). Intox. group compared with control group using student's-t, test (***P < 0.001) and AESM is compared to intox. group using statistical analysis done by ANOVA followed by Dunnet's test (**P < 0.05,**P < 0.01)
Mentions: Subcutaneous injection of milk at a dose of 4 ml/kg produced a significant (***P < 0.001) increase in the leukocyte and total eosinophil count, 24 h after its administration. In the groups of mice pretreated with aqueous extract of A. excelsa Roxb. at doses of 100, 200 and 400 mg/kg p.o., there was significant (**P < 0.01) inhibition of milk-induced leukocytosis at 200 and 400 mg/kg p.o. doses, and in milk-induced eosinophilia, there was significant (*P < 0.05,**P < 0.01) inhibition of milk-induced eosinophilia at all the three doses [Figures 1 and 2].

Bottom Line: Stem bark of A. excelsa Roxb. has been used as a decoction in traditional claims.So, our traditional claims enforced us to evaluate its bronchodilator activity.The aqueous extract of stem bark in doses of 100, 200, 400 mg/kg showed significant activity.

View Article: PubMed Central - PubMed

Affiliation: Rayat Institute of Pharmacy, Railmajra, S.B.S. Nagar, Punjab, India.

ABSTRACT
Biologically active compounds from natural sources are of interest as possible new drugs for infectious diseases. Ailanthus excelsa Roxb. has been used in Indian system of medicine in the treatment of asthma, bronchitis, cold, colic pain, etc. Stem bark of A. excelsa Roxb. has been used as a decoction in traditional claims. So, our traditional claims enforced us to evaluate its bronchodilator activity. We have evaluated its bronchodilator activity in milk-induced leukocytosis and eosinophilia, clonidine-induced mast cell degranulation, bronchoalveolar lavage fluid (BALF), and lung histopathology models. The aqueous extract of stem bark in doses of 100, 200, 400 mg/kg showed significant activity.

No MeSH data available.


Related in: MedlinePlus