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Herbal medicine and hepatocellular carcinoma: applications and challenges.

Li Y, Martin RC - Evid Based Complement Alternat Med (2011)

Bottom Line: In the past, certain herbal compounds and herbal composite formulas have been studied through in vitro and in vivo as an anti-hepatocellular carcinoma (HCC) agent, enhancing our knowledge about their biologic functions and targets.However there is a significant distinction between the herbal medicine and the herbal production even though both are the plant-based remedies used in the practice.In this article, for the sake of clarity, the effective herbal compounds and herbal composite formulas against HCC are discussed, with emphasizing the basic conceptions of herbal medicine in order to have a better understanding of the prevention and treatment of HCC by herbal active compounds and herbal composite formulas.

View Article: PubMed Central - PubMed

Affiliation: Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40202, USA.

ABSTRACT
Use of herbal medicine in the treatment of liver cancer has a long tradition. The compounds derived from the herb and herbal composites are of considerable interest among oncologists. In the past, certain herbal compounds and herbal composite formulas have been studied through in vitro and in vivo as an anti-hepatocellular carcinoma (HCC) agent, enhancing our knowledge about their biologic functions and targets. However there is a significant distinction between the herbal medicine and the herbal production even though both are the plant-based remedies used in the practice. In this article, for the sake of clarity, the effective herbal compounds and herbal composite formulas against HCC are discussed, with emphasizing the basic conceptions of herbal medicine in order to have a better understanding of the prevention and treatment of HCC by herbal active compounds and herbal composite formulas.

No MeSH data available.


Related in: MedlinePlus

QUORUM algorithm of review of the herbal medicine publications and abstracts.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: QUORUM algorithm of review of the herbal medicine publications and abstracts.

Mentions: In this article, for the sake of clarity, we divided the herbal medicine into effective herbal compounds and herbal composite formula to discuss their anticancer properties against HCC. Several reviews have provided major contributions to the current knowledge on the herbal medicines for treatment of liver fibrosis and cancer [20–23]. The basic concepts of these “botanical drugs" are emphasized in order to have a better understanding of the prevention and treatment of HCC by herbal active compounds and herbal composite formula. The reports from both Chinese and English language are reviewed to provide a full picture of the progression of the use of herbal medicine against HCC. The English literature searches were conducted through Medline, Embase, Science Citation Index, Current Contents, PubMed databases, as well as relevant papers from integrative and complementary medicine journals, such as Evidence Based Complementary and Alternative Medicine, until January 2009. The outline of articles reviewed is presented in a Quality of Reporting of Meta-Analysis (QUORUM) flow chart showing the number of studies screened and included in the meta-analysis (Figure 1) [24]. Search items were “herb", “anticancer mechanism", “traditional Chinese medicine", “hepatoma", “hepatocellular carcinoma" and “hepatocellular adenocarcinoma". Restrictions were placed on language of publication, and only English was included. Studies lacking controls were excluded. Case reports were excluded. The relevant Chinese literature searches were carried out through Wanfang data until January 2009 using database of China Medical Association Journals (CMAJ), which is a portal to medical research materials published in China. The exclusion and inclusion for extracted data from literatures were same as that in PubMed. These restrictions were placed in order to have consistency among the reports reviewed. The aim of this review was to evaluate the current literature for the efficacy and safety of current herbal compounds in the treatment of hepatocellular cancer.


Herbal medicine and hepatocellular carcinoma: applications and challenges.

Li Y, Martin RC - Evid Based Complement Alternat Med (2011)

QUORUM algorithm of review of the herbal medicine publications and abstracts.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3140057&req=5

fig1: QUORUM algorithm of review of the herbal medicine publications and abstracts.
Mentions: In this article, for the sake of clarity, we divided the herbal medicine into effective herbal compounds and herbal composite formula to discuss their anticancer properties against HCC. Several reviews have provided major contributions to the current knowledge on the herbal medicines for treatment of liver fibrosis and cancer [20–23]. The basic concepts of these “botanical drugs" are emphasized in order to have a better understanding of the prevention and treatment of HCC by herbal active compounds and herbal composite formula. The reports from both Chinese and English language are reviewed to provide a full picture of the progression of the use of herbal medicine against HCC. The English literature searches were conducted through Medline, Embase, Science Citation Index, Current Contents, PubMed databases, as well as relevant papers from integrative and complementary medicine journals, such as Evidence Based Complementary and Alternative Medicine, until January 2009. The outline of articles reviewed is presented in a Quality of Reporting of Meta-Analysis (QUORUM) flow chart showing the number of studies screened and included in the meta-analysis (Figure 1) [24]. Search items were “herb", “anticancer mechanism", “traditional Chinese medicine", “hepatoma", “hepatocellular carcinoma" and “hepatocellular adenocarcinoma". Restrictions were placed on language of publication, and only English was included. Studies lacking controls were excluded. Case reports were excluded. The relevant Chinese literature searches were carried out through Wanfang data until January 2009 using database of China Medical Association Journals (CMAJ), which is a portal to medical research materials published in China. The exclusion and inclusion for extracted data from literatures were same as that in PubMed. These restrictions were placed in order to have consistency among the reports reviewed. The aim of this review was to evaluate the current literature for the efficacy and safety of current herbal compounds in the treatment of hepatocellular cancer.

Bottom Line: In the past, certain herbal compounds and herbal composite formulas have been studied through in vitro and in vivo as an anti-hepatocellular carcinoma (HCC) agent, enhancing our knowledge about their biologic functions and targets.However there is a significant distinction between the herbal medicine and the herbal production even though both are the plant-based remedies used in the practice.In this article, for the sake of clarity, the effective herbal compounds and herbal composite formulas against HCC are discussed, with emphasizing the basic conceptions of herbal medicine in order to have a better understanding of the prevention and treatment of HCC by herbal active compounds and herbal composite formulas.

View Article: PubMed Central - PubMed

Affiliation: Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40202, USA.

ABSTRACT
Use of herbal medicine in the treatment of liver cancer has a long tradition. The compounds derived from the herb and herbal composites are of considerable interest among oncologists. In the past, certain herbal compounds and herbal composite formulas have been studied through in vitro and in vivo as an anti-hepatocellular carcinoma (HCC) agent, enhancing our knowledge about their biologic functions and targets. However there is a significant distinction between the herbal medicine and the herbal production even though both are the plant-based remedies used in the practice. In this article, for the sake of clarity, the effective herbal compounds and herbal composite formulas against HCC are discussed, with emphasizing the basic conceptions of herbal medicine in order to have a better understanding of the prevention and treatment of HCC by herbal active compounds and herbal composite formulas.

No MeSH data available.


Related in: MedlinePlus