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Mumijo traditional medicine: fossil deposits from antarctica (chemical composition and beneficial bioactivity).

Aiello A, Fattorusso E, Menna M, Vitalone R, Schröder HC, Müller WE - Evid Based Complement Alternat Med (2010)

Bottom Line: Extensive purification and chemical analysis revealed that the fossil samples are a mixture of glycerol derivatives.In addition, the fraction rich in glycerol ethers/wax esters displayed a significant growth-promoting activity in permanent neuronal PC12 cells.It is concluded that this new Mumijo preparation has distinct and marked neuroprotective activity, very likely due to the content of glycerol ether derivatives.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli "Federico II", via D. Montesano 49, 80131 Napoli, Italy.

ABSTRACT
Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune-stimulating and antiallergic activity as well. In the present study, we investigate the chemical composition and the biomedical potential of a Mumijo(-related) product collected from the Antarctica. The yellow material originates from the snow petrels, Pagodroma nivea. Extensive purification and chemical analysis revealed that the fossil samples are a mixture of glycerol derivatives. In vitro experiments showed that the Mumijo extract caused in cortical neurons a strong neuroprotective effect against the apoptosis-inducing amyloid peptide fragment β-fragment 25-35 (Aβ25-35). In addition, the fraction rich in glycerol ethers/wax esters displayed a significant growth-promoting activity in permanent neuronal PC12 cells. It is concluded that this new Mumijo preparation has distinct and marked neuroprotective activity, very likely due to the content of glycerol ether derivatives.

No MeSH data available.


Related in: MedlinePlus

Main biomedical activity (established as well as expected from literature data) of the different organic fractions, which have been separated from Antarctic Mumijo. A further potential can be supposed from the inorganic component(s), the minerals, with respect to their ameliorating function in bone diseases. The scheme shows also a cross section through a Mumijo sample from Antarctica (size: 2.5 cm). The layered deposition of the waxy organic material is self-evident.
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fig4: Main biomedical activity (established as well as expected from literature data) of the different organic fractions, which have been separated from Antarctic Mumijo. A further potential can be supposed from the inorganic component(s), the minerals, with respect to their ameliorating function in bone diseases. The scheme shows also a cross section through a Mumijo sample from Antarctica (size: 2.5 cm). The layered deposition of the waxy organic material is self-evident.

Mentions: Taken together, our data presented here show that the Antarctic Mumijo is rich in glyceryl ether derivatives which—according to the data given—display distinct and marked neuroprotective activity. Schematically, the biomedical potential of Antarctic Mumijo is summarized in Figure 4. The main organic components, the wax esters and the glycerol ethers, are known to display neuroprotective potential. Future studies will prove if the monoalkyl ethers display also anti-stomach ache capacity. Finally, the triglycerides have to be studied for their putative antimicrobial activity. The inorganic component(s), the minerals existing in Mumijo, may have their ameliorating function in bone diseases. An outline of the exploitation strategies for traditional and modern drugs applicable in the biomedicine has been given for the Mediterranean region [45].


Mumijo traditional medicine: fossil deposits from antarctica (chemical composition and beneficial bioactivity).

Aiello A, Fattorusso E, Menna M, Vitalone R, Schröder HC, Müller WE - Evid Based Complement Alternat Med (2010)

Main biomedical activity (established as well as expected from literature data) of the different organic fractions, which have been separated from Antarctic Mumijo. A further potential can be supposed from the inorganic component(s), the minerals, with respect to their ameliorating function in bone diseases. The scheme shows also a cross section through a Mumijo sample from Antarctica (size: 2.5 cm). The layered deposition of the waxy organic material is self-evident.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3139983&req=5

fig4: Main biomedical activity (established as well as expected from literature data) of the different organic fractions, which have been separated from Antarctic Mumijo. A further potential can be supposed from the inorganic component(s), the minerals, with respect to their ameliorating function in bone diseases. The scheme shows also a cross section through a Mumijo sample from Antarctica (size: 2.5 cm). The layered deposition of the waxy organic material is self-evident.
Mentions: Taken together, our data presented here show that the Antarctic Mumijo is rich in glyceryl ether derivatives which—according to the data given—display distinct and marked neuroprotective activity. Schematically, the biomedical potential of Antarctic Mumijo is summarized in Figure 4. The main organic components, the wax esters and the glycerol ethers, are known to display neuroprotective potential. Future studies will prove if the monoalkyl ethers display also anti-stomach ache capacity. Finally, the triglycerides have to be studied for their putative antimicrobial activity. The inorganic component(s), the minerals existing in Mumijo, may have their ameliorating function in bone diseases. An outline of the exploitation strategies for traditional and modern drugs applicable in the biomedicine has been given for the Mediterranean region [45].

Bottom Line: Extensive purification and chemical analysis revealed that the fossil samples are a mixture of glycerol derivatives.In addition, the fraction rich in glycerol ethers/wax esters displayed a significant growth-promoting activity in permanent neuronal PC12 cells.It is concluded that this new Mumijo preparation has distinct and marked neuroprotective activity, very likely due to the content of glycerol ether derivatives.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli "Federico II", via D. Montesano 49, 80131 Napoli, Italy.

ABSTRACT
Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune-stimulating and antiallergic activity as well. In the present study, we investigate the chemical composition and the biomedical potential of a Mumijo(-related) product collected from the Antarctica. The yellow material originates from the snow petrels, Pagodroma nivea. Extensive purification and chemical analysis revealed that the fossil samples are a mixture of glycerol derivatives. In vitro experiments showed that the Mumijo extract caused in cortical neurons a strong neuroprotective effect against the apoptosis-inducing amyloid peptide fragment β-fragment 25-35 (Aβ25-35). In addition, the fraction rich in glycerol ethers/wax esters displayed a significant growth-promoting activity in permanent neuronal PC12 cells. It is concluded that this new Mumijo preparation has distinct and marked neuroprotective activity, very likely due to the content of glycerol ether derivatives.

No MeSH data available.


Related in: MedlinePlus