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Andrographolide: a new plant-derived antineoplastic entity on horizon.

Varma A, Padh H, Shrivastava N - Evid Based Complement Alternat Med (2011)

Bottom Line: Andrographolide, the principal bioactive chemical constituent of the plant has shown credible anticancer potential in various investigations around the globe.Andrographolide also shows potent immunomodulatory and anti-angiogenic activities in tumorous tissues.Synthetic analogues of the compound have also been created and analyzed, which have also shown similar activities.

View Article: PubMed Central - PubMed

Affiliation: B. V. Patel Pharmaceutical Education & Research Development (PERD) Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad 380054, Gujarat, India.

ABSTRACT
Plant-derived natural products occupy an important position in the area of cancer chemotherapy. Molecules such as vincristine, vinblastine, paclitaxel, camptothecin derivatives, epipodophyllotoxin, and so forth, are invaluable contributions of nature to modern medicine. However, the quest to find out novel therapeutic compounds for cancer treatment and management is a never-ending venture; and diverse plant species are persistently being studied for identification of prospective anticancer agents. In this regard, Andrographis paniculata Nees, a well-known plant of Indian and Chinese traditional system of medicines, has drawn attention of researchers in recent times. Andrographolide, the principal bioactive chemical constituent of the plant has shown credible anticancer potential in various investigations around the globe. In vitro studies demonstrate the capability of the compound of inducing cell-cycle arrest and apoptosis in a variety of cancer cells at different concentrations. Andrographolide also shows potent immunomodulatory and anti-angiogenic activities in tumorous tissues. Synthetic analogues of the compound have also been created and analyzed, which have also shown similar activities. Although it is too early to predict its future in cancer chemotherapy, the prologue strongly recommends further research on this molecule to assess its potential as a prospective anticancer agent.

No MeSH data available.


Related in: MedlinePlus

Effect of andrographolide treatment on cancer cells. Cancer is a multifaceted disease with complex processes and requires a multi-target therapeutic approach to battle it. A similar kind of action is displayed by andrographolide as it modulates various biochemical pathways of cancer cells thereby inhibiting the tumor growth. The compound exerts cytotoxic effect on various cancer cell types in a time and dose dependent manner. Factors required for tumor progression, nourishment and metastasis are down regulated, that is, cyclins A, D, Cdk2, Cdk4, NF-κB, VEGF, E-selectin, VCAM, Akt, TNF, Bcl2, and so forth. On the other hand tumor suppressor elements like p53, caspases, inhibitory proteins p21, p16, p27, and so forth are up regulated as observed in various studies to investigate anti-cancer potential of andrographolide. Up regulation of death receptor 4 to facilitate TRAIL induced apoptosis is of significant interest. The cumulative effect of all these factorial events leads to inhibition of growth in cancer cells. The alphabets placed adjacent to the petals refer to the reference numbers of articles. a [35, 45, 47, 49, 50]; b [49, 50, 60, 66, 68]; c [60, 62]; d [82]; e [37, 46, 87]; f [71–73]; g [34, 37, 45, 48]; h [34, 60, 74].
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fig2: Effect of andrographolide treatment on cancer cells. Cancer is a multifaceted disease with complex processes and requires a multi-target therapeutic approach to battle it. A similar kind of action is displayed by andrographolide as it modulates various biochemical pathways of cancer cells thereby inhibiting the tumor growth. The compound exerts cytotoxic effect on various cancer cell types in a time and dose dependent manner. Factors required for tumor progression, nourishment and metastasis are down regulated, that is, cyclins A, D, Cdk2, Cdk4, NF-κB, VEGF, E-selectin, VCAM, Akt, TNF, Bcl2, and so forth. On the other hand tumor suppressor elements like p53, caspases, inhibitory proteins p21, p16, p27, and so forth are up regulated as observed in various studies to investigate anti-cancer potential of andrographolide. Up regulation of death receptor 4 to facilitate TRAIL induced apoptosis is of significant interest. The cumulative effect of all these factorial events leads to inhibition of growth in cancer cells. The alphabets placed adjacent to the petals refer to the reference numbers of articles. a [35, 45, 47, 49, 50]; b [49, 50, 60, 66, 68]; c [60, 62]; d [82]; e [37, 46, 87]; f [71–73]; g [34, 37, 45, 48]; h [34, 60, 74].

Mentions: Cancer cells are known to induce angiogenesis for continuous supply of nutrients to the proliferating cells. As angiogenesis is triggered in response to chronic inflammation, there is a direct relation between inflammation, carcinogenesis and angiogenesis. Therefore, owing to its excellent anti-inflammatory activity, andrographolide has been evaluated for its anti-angiogenic potential as well. As an anti-angiogenic prospect, andrographolide could successfully inhibit the tumor specific capillary sprouting without damaging the pre-existing vasculature. Andrographolide administration also down-regulated the production of various angiogenic factors like vascular endothelial growth factor (VEGF), nitric oxide (NO) and pro-inflammatory cytokines and elevated the levels of anti-angiogenic factors like IL-2 and tissue inhibitor of metalloproteinase (TIMP-1) in vitro as well as in vivo [74]. VEGF is by and large used by cancer cells as a survival factor and the inhibitory activity of andrographolide on VEGF levels has been verified [34]. A schematic diagram depicting the multitarget potential of andrographolide is presented as Figure 2.


Andrographolide: a new plant-derived antineoplastic entity on horizon.

Varma A, Padh H, Shrivastava N - Evid Based Complement Alternat Med (2011)

Effect of andrographolide treatment on cancer cells. Cancer is a multifaceted disease with complex processes and requires a multi-target therapeutic approach to battle it. A similar kind of action is displayed by andrographolide as it modulates various biochemical pathways of cancer cells thereby inhibiting the tumor growth. The compound exerts cytotoxic effect on various cancer cell types in a time and dose dependent manner. Factors required for tumor progression, nourishment and metastasis are down regulated, that is, cyclins A, D, Cdk2, Cdk4, NF-κB, VEGF, E-selectin, VCAM, Akt, TNF, Bcl2, and so forth. On the other hand tumor suppressor elements like p53, caspases, inhibitory proteins p21, p16, p27, and so forth are up regulated as observed in various studies to investigate anti-cancer potential of andrographolide. Up regulation of death receptor 4 to facilitate TRAIL induced apoptosis is of significant interest. The cumulative effect of all these factorial events leads to inhibition of growth in cancer cells. The alphabets placed adjacent to the petals refer to the reference numbers of articles. a [35, 45, 47, 49, 50]; b [49, 50, 60, 66, 68]; c [60, 62]; d [82]; e [37, 46, 87]; f [71–73]; g [34, 37, 45, 48]; h [34, 60, 74].
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3139959&req=5

fig2: Effect of andrographolide treatment on cancer cells. Cancer is a multifaceted disease with complex processes and requires a multi-target therapeutic approach to battle it. A similar kind of action is displayed by andrographolide as it modulates various biochemical pathways of cancer cells thereby inhibiting the tumor growth. The compound exerts cytotoxic effect on various cancer cell types in a time and dose dependent manner. Factors required for tumor progression, nourishment and metastasis are down regulated, that is, cyclins A, D, Cdk2, Cdk4, NF-κB, VEGF, E-selectin, VCAM, Akt, TNF, Bcl2, and so forth. On the other hand tumor suppressor elements like p53, caspases, inhibitory proteins p21, p16, p27, and so forth are up regulated as observed in various studies to investigate anti-cancer potential of andrographolide. Up regulation of death receptor 4 to facilitate TRAIL induced apoptosis is of significant interest. The cumulative effect of all these factorial events leads to inhibition of growth in cancer cells. The alphabets placed adjacent to the petals refer to the reference numbers of articles. a [35, 45, 47, 49, 50]; b [49, 50, 60, 66, 68]; c [60, 62]; d [82]; e [37, 46, 87]; f [71–73]; g [34, 37, 45, 48]; h [34, 60, 74].
Mentions: Cancer cells are known to induce angiogenesis for continuous supply of nutrients to the proliferating cells. As angiogenesis is triggered in response to chronic inflammation, there is a direct relation between inflammation, carcinogenesis and angiogenesis. Therefore, owing to its excellent anti-inflammatory activity, andrographolide has been evaluated for its anti-angiogenic potential as well. As an anti-angiogenic prospect, andrographolide could successfully inhibit the tumor specific capillary sprouting without damaging the pre-existing vasculature. Andrographolide administration also down-regulated the production of various angiogenic factors like vascular endothelial growth factor (VEGF), nitric oxide (NO) and pro-inflammatory cytokines and elevated the levels of anti-angiogenic factors like IL-2 and tissue inhibitor of metalloproteinase (TIMP-1) in vitro as well as in vivo [74]. VEGF is by and large used by cancer cells as a survival factor and the inhibitory activity of andrographolide on VEGF levels has been verified [34]. A schematic diagram depicting the multitarget potential of andrographolide is presented as Figure 2.

Bottom Line: Andrographolide, the principal bioactive chemical constituent of the plant has shown credible anticancer potential in various investigations around the globe.Andrographolide also shows potent immunomodulatory and anti-angiogenic activities in tumorous tissues.Synthetic analogues of the compound have also been created and analyzed, which have also shown similar activities.

View Article: PubMed Central - PubMed

Affiliation: B. V. Patel Pharmaceutical Education & Research Development (PERD) Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad 380054, Gujarat, India.

ABSTRACT
Plant-derived natural products occupy an important position in the area of cancer chemotherapy. Molecules such as vincristine, vinblastine, paclitaxel, camptothecin derivatives, epipodophyllotoxin, and so forth, are invaluable contributions of nature to modern medicine. However, the quest to find out novel therapeutic compounds for cancer treatment and management is a never-ending venture; and diverse plant species are persistently being studied for identification of prospective anticancer agents. In this regard, Andrographis paniculata Nees, a well-known plant of Indian and Chinese traditional system of medicines, has drawn attention of researchers in recent times. Andrographolide, the principal bioactive chemical constituent of the plant has shown credible anticancer potential in various investigations around the globe. In vitro studies demonstrate the capability of the compound of inducing cell-cycle arrest and apoptosis in a variety of cancer cells at different concentrations. Andrographolide also shows potent immunomodulatory and anti-angiogenic activities in tumorous tissues. Synthetic analogues of the compound have also been created and analyzed, which have also shown similar activities. Although it is too early to predict its future in cancer chemotherapy, the prologue strongly recommends further research on this molecule to assess its potential as a prospective anticancer agent.

No MeSH data available.


Related in: MedlinePlus