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Andrographolide: a new plant-derived antineoplastic entity on horizon.

Varma A, Padh H, Shrivastava N - Evid Based Complement Alternat Med (2011)

Bottom Line: Andrographolide, the principal bioactive chemical constituent of the plant has shown credible anticancer potential in various investigations around the globe.Andrographolide also shows potent immunomodulatory and anti-angiogenic activities in tumorous tissues.Synthetic analogues of the compound have also been created and analyzed, which have also shown similar activities.

View Article: PubMed Central - PubMed

Affiliation: B. V. Patel Pharmaceutical Education & Research Development (PERD) Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad 380054, Gujarat, India.

ABSTRACT
Plant-derived natural products occupy an important position in the area of cancer chemotherapy. Molecules such as vincristine, vinblastine, paclitaxel, camptothecin derivatives, epipodophyllotoxin, and so forth, are invaluable contributions of nature to modern medicine. However, the quest to find out novel therapeutic compounds for cancer treatment and management is a never-ending venture; and diverse plant species are persistently being studied for identification of prospective anticancer agents. In this regard, Andrographis paniculata Nees, a well-known plant of Indian and Chinese traditional system of medicines, has drawn attention of researchers in recent times. Andrographolide, the principal bioactive chemical constituent of the plant has shown credible anticancer potential in various investigations around the globe. In vitro studies demonstrate the capability of the compound of inducing cell-cycle arrest and apoptosis in a variety of cancer cells at different concentrations. Andrographolide also shows potent immunomodulatory and anti-angiogenic activities in tumorous tissues. Synthetic analogues of the compound have also been created and analyzed, which have also shown similar activities. Although it is too early to predict its future in cancer chemotherapy, the prologue strongly recommends further research on this molecule to assess its potential as a prospective anticancer agent.

No MeSH data available.


Related in: MedlinePlus

Structure of the principle phytochemical compound of A. paniculata Nees, andrographolide.
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Related In: Results  -  Collection


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fig1: Structure of the principle phytochemical compound of A. paniculata Nees, andrographolide.

Mentions: Andrographis paniculata (Burm. F.) Nees (family, Acanthaceae) grows widely in many Asian countries such as China, India, Thailand and Sri Lanka [14] and has a long history of therapeutic usage in Indian and Oriental medicine [15, 16]. The herb is official in Indian Pharmacopoeia [17] as a predominant constituent of at least 26 Ayurvedic formulations used to treat liver disorders. It is one of the herbs, which can be used to treat neoplasm as mentioned in ancient Ayurvedic literature [18]. Andrographis paniculata is reported as a cold property herb in TCM and is used to get rid of body heat and to expel toxins. The plant is particularly known for its extremely bitter properties (often called king of bitters) and is used traditionally as a remedy against common cold, dysentery, fever, tonsillitis, diarrhoea, liver diseases, inflammation, herpes, and so forth [19–21]. The traditional uses and pharmacological aspects of A. paniculata have been well-documented in an extensive review recently [22]. A number of active principles are reported from the plant, which mainly include diterpene lactones, flavonoids and polyphenols [23, 24]. However, the prime constituent andrographolide has been is mainly attributed for its therapeutic properties. Diterpenoid lactone andrographolide (C20H30O5) is the principle compound found in A. paniculata, which is mainly concentrated in leaves and can be easily isolated from the crude plant extracts as crystalline solid [25, 26]. The structure of the compound has been elucidated by X-Ray crystallographic analysis and the molecular stereochemistry, bond distances, bond angles, and so forth all were determined [27]. Chemically designated as (3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5, 8-adimethyl-2-methylene-1-napthalenyl] ethylidene] dihydro-4-hydroxy-2(3H)-furanone), andrographolide (Figure 1) exhibits extraordinarily vast range of biological activities [28–33]. In recent past, the compound is reported for its anti-tumor, anti-HIV and cardio-protective properties [15, 34–39]. However, it shows a weak anti-microbial activity against bacteria and viruses [40].


Andrographolide: a new plant-derived antineoplastic entity on horizon.

Varma A, Padh H, Shrivastava N - Evid Based Complement Alternat Med (2011)

Structure of the principle phytochemical compound of A. paniculata Nees, andrographolide.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3139959&req=5

fig1: Structure of the principle phytochemical compound of A. paniculata Nees, andrographolide.
Mentions: Andrographis paniculata (Burm. F.) Nees (family, Acanthaceae) grows widely in many Asian countries such as China, India, Thailand and Sri Lanka [14] and has a long history of therapeutic usage in Indian and Oriental medicine [15, 16]. The herb is official in Indian Pharmacopoeia [17] as a predominant constituent of at least 26 Ayurvedic formulations used to treat liver disorders. It is one of the herbs, which can be used to treat neoplasm as mentioned in ancient Ayurvedic literature [18]. Andrographis paniculata is reported as a cold property herb in TCM and is used to get rid of body heat and to expel toxins. The plant is particularly known for its extremely bitter properties (often called king of bitters) and is used traditionally as a remedy against common cold, dysentery, fever, tonsillitis, diarrhoea, liver diseases, inflammation, herpes, and so forth [19–21]. The traditional uses and pharmacological aspects of A. paniculata have been well-documented in an extensive review recently [22]. A number of active principles are reported from the plant, which mainly include diterpene lactones, flavonoids and polyphenols [23, 24]. However, the prime constituent andrographolide has been is mainly attributed for its therapeutic properties. Diterpenoid lactone andrographolide (C20H30O5) is the principle compound found in A. paniculata, which is mainly concentrated in leaves and can be easily isolated from the crude plant extracts as crystalline solid [25, 26]. The structure of the compound has been elucidated by X-Ray crystallographic analysis and the molecular stereochemistry, bond distances, bond angles, and so forth all were determined [27]. Chemically designated as (3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5, 8-adimethyl-2-methylene-1-napthalenyl] ethylidene] dihydro-4-hydroxy-2(3H)-furanone), andrographolide (Figure 1) exhibits extraordinarily vast range of biological activities [28–33]. In recent past, the compound is reported for its anti-tumor, anti-HIV and cardio-protective properties [15, 34–39]. However, it shows a weak anti-microbial activity against bacteria and viruses [40].

Bottom Line: Andrographolide, the principal bioactive chemical constituent of the plant has shown credible anticancer potential in various investigations around the globe.Andrographolide also shows potent immunomodulatory and anti-angiogenic activities in tumorous tissues.Synthetic analogues of the compound have also been created and analyzed, which have also shown similar activities.

View Article: PubMed Central - PubMed

Affiliation: B. V. Patel Pharmaceutical Education & Research Development (PERD) Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad 380054, Gujarat, India.

ABSTRACT
Plant-derived natural products occupy an important position in the area of cancer chemotherapy. Molecules such as vincristine, vinblastine, paclitaxel, camptothecin derivatives, epipodophyllotoxin, and so forth, are invaluable contributions of nature to modern medicine. However, the quest to find out novel therapeutic compounds for cancer treatment and management is a never-ending venture; and diverse plant species are persistently being studied for identification of prospective anticancer agents. In this regard, Andrographis paniculata Nees, a well-known plant of Indian and Chinese traditional system of medicines, has drawn attention of researchers in recent times. Andrographolide, the principal bioactive chemical constituent of the plant has shown credible anticancer potential in various investigations around the globe. In vitro studies demonstrate the capability of the compound of inducing cell-cycle arrest and apoptosis in a variety of cancer cells at different concentrations. Andrographolide also shows potent immunomodulatory and anti-angiogenic activities in tumorous tissues. Synthetic analogues of the compound have also been created and analyzed, which have also shown similar activities. Although it is too early to predict its future in cancer chemotherapy, the prologue strongly recommends further research on this molecule to assess its potential as a prospective anticancer agent.

No MeSH data available.


Related in: MedlinePlus