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Interhemispheric Connectivity Influences the Degree of Modulation of TMS-Induced Effects during Auditory Processing.

Andoh J, Zatorre RJ - Front Psychol (2011)

Bottom Line: However, not much is known about its effects on nonlinguistic auditory processing, especially its action on Heschl's gyrus (HG).TMS results showed that 10 Hz-rTMS targeting the right HG induced differential effects according to sex, with a facilitation of performance in females and an impairment of performance in males.We also found a differential correlation between the %RT change after 10 Hz-rTMS targeting the right HG and the interhemispheric functional connectivity between right and left HG, indicating that an increase in interhemispheric functional connectivity was associated with a facilitation of performance.

View Article: PubMed Central - PubMed

Affiliation: Montreal Neurological Institute, McGill University Montreal, QC, Canada.

ABSTRACT
Repetitive transcranial magnetic stimulation (rTMS) has been shown to interfere with many components of language processing, including semantic, syntactic, and phonologic. However, not much is known about its effects on nonlinguistic auditory processing, especially its action on Heschl's gyrus (HG). We aimed to investigate the behavioral and neural basis of rTMS during a melody processing task, while targeting the left HG, the right HG, and the Vertex as a control site. Response times (RT) were normalized relative to the baseline-rTMS (Vertex) and expressed as percentage change from baseline (%RT change). We also looked at sex differences in rTMS-induced response as well as in functional connectivity during melody processing using rTMS and functional magnetic resonance imaging (fMRI). fMRI results showed an increase in the right HG compared with the left HG during the melody task, as well as sex differences in functional connectivity indicating a greater interhemispheric connectivity between left and right HG in females compared with males. TMS results showed that 10 Hz-rTMS targeting the right HG induced differential effects according to sex, with a facilitation of performance in females and an impairment of performance in males. We also found a differential correlation between the %RT change after 10 Hz-rTMS targeting the right HG and the interhemispheric functional connectivity between right and left HG, indicating that an increase in interhemispheric functional connectivity was associated with a facilitation of performance. This is the first study to report a differential rTMS-induced interference with melody processing depending on sex. In addition, we showed a relationship between the interference induced by rTMS on behavioral performance and the neural activity in the network connecting left and right HG, suggesting that the interhemispheric functional connectivity could determine the degree of modulation of behavioral performance.

No MeSH data available.


(A) 3D left hemisphere view of a whole-group analysis (including females and males) of the functional connectivity maps using the right HG as a seed ROI and adding (left) the %RT change with 10 Hz-rTMS targeting the right HG at time 1 (i. e., 0–5.5 min) as a covariate and (right) the %RT change with 10 Hz-rTMS targeting the left HG at time 1 (i.e., 0–5.5 min) as a covariate. (B). Three dimensional right hemisphere view of a whole-group analysis (including female and male) of the functional connectivity maps using the left HG as a seed ROI and adding (left) the %RT change when 1 Hz-rTMS targeted the left HG at time 1 (i.e., 0–5.5 min) as a covariate and (right) the %RT change when 1 Hz-rTMS targeted the right HG at time 1 (i.e., 0–5.5 min) as a covariate. (C) 3D left hemisphere view of a whole-group analysis (including female and male) of the functional connectivity maps using the right HG as a seed ROI and adding (left) the %RT change when 10 Hz-rTMS targeted the right HG at time 2 (i.e., 5.5–11 min) as a covariate and (right) the %RT change when 10 Hz-rTMS targeted the left HG at time 2 (i.e., 5.5–11 min) as a covariate. Three dimensional views were displayed by cutting sagittal slices through the left temporal cortex in order to focus on left temporal regions.
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Figure 6: (A) 3D left hemisphere view of a whole-group analysis (including females and males) of the functional connectivity maps using the right HG as a seed ROI and adding (left) the %RT change with 10 Hz-rTMS targeting the right HG at time 1 (i. e., 0–5.5 min) as a covariate and (right) the %RT change with 10 Hz-rTMS targeting the left HG at time 1 (i.e., 0–5.5 min) as a covariate. (B). Three dimensional right hemisphere view of a whole-group analysis (including female and male) of the functional connectivity maps using the left HG as a seed ROI and adding (left) the %RT change when 1 Hz-rTMS targeted the left HG at time 1 (i.e., 0–5.5 min) as a covariate and (right) the %RT change when 1 Hz-rTMS targeted the right HG at time 1 (i.e., 0–5.5 min) as a covariate. (C) 3D left hemisphere view of a whole-group analysis (including female and male) of the functional connectivity maps using the right HG as a seed ROI and adding (left) the %RT change when 10 Hz-rTMS targeted the right HG at time 2 (i.e., 5.5–11 min) as a covariate and (right) the %RT change when 10 Hz-rTMS targeted the left HG at time 2 (i.e., 5.5–11 min) as a covariate. Three dimensional views were displayed by cutting sagittal slices through the left temporal cortex in order to focus on left temporal regions.

Mentions: We found a negative correlation between the %RT change caused by 10 Hz-rTMS targeting rHG and the functional interhemispheric connectivity between right and left auditory cortices, including bilateral STG, bilateral MTG and the left HG (see Figure 6A, left). This result shows that the higher the functional connectivity between left and right auditory cortices, the higher the facilitation (%RT decrease) caused by 10 Hz-rTMS over the right HG.


Interhemispheric Connectivity Influences the Degree of Modulation of TMS-Induced Effects during Auditory Processing.

Andoh J, Zatorre RJ - Front Psychol (2011)

(A) 3D left hemisphere view of a whole-group analysis (including females and males) of the functional connectivity maps using the right HG as a seed ROI and adding (left) the %RT change with 10 Hz-rTMS targeting the right HG at time 1 (i. e., 0–5.5 min) as a covariate and (right) the %RT change with 10 Hz-rTMS targeting the left HG at time 1 (i.e., 0–5.5 min) as a covariate. (B). Three dimensional right hemisphere view of a whole-group analysis (including female and male) of the functional connectivity maps using the left HG as a seed ROI and adding (left) the %RT change when 1 Hz-rTMS targeted the left HG at time 1 (i.e., 0–5.5 min) as a covariate and (right) the %RT change when 1 Hz-rTMS targeted the right HG at time 1 (i.e., 0–5.5 min) as a covariate. (C) 3D left hemisphere view of a whole-group analysis (including female and male) of the functional connectivity maps using the right HG as a seed ROI and adding (left) the %RT change when 10 Hz-rTMS targeted the right HG at time 2 (i.e., 5.5–11 min) as a covariate and (right) the %RT change when 10 Hz-rTMS targeted the left HG at time 2 (i.e., 5.5–11 min) as a covariate. Three dimensional views were displayed by cutting sagittal slices through the left temporal cortex in order to focus on left temporal regions.
© Copyright Policy - open-access
Related In: Results  -  Collection

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Figure 6: (A) 3D left hemisphere view of a whole-group analysis (including females and males) of the functional connectivity maps using the right HG as a seed ROI and adding (left) the %RT change with 10 Hz-rTMS targeting the right HG at time 1 (i. e., 0–5.5 min) as a covariate and (right) the %RT change with 10 Hz-rTMS targeting the left HG at time 1 (i.e., 0–5.5 min) as a covariate. (B). Three dimensional right hemisphere view of a whole-group analysis (including female and male) of the functional connectivity maps using the left HG as a seed ROI and adding (left) the %RT change when 1 Hz-rTMS targeted the left HG at time 1 (i.e., 0–5.5 min) as a covariate and (right) the %RT change when 1 Hz-rTMS targeted the right HG at time 1 (i.e., 0–5.5 min) as a covariate. (C) 3D left hemisphere view of a whole-group analysis (including female and male) of the functional connectivity maps using the right HG as a seed ROI and adding (left) the %RT change when 10 Hz-rTMS targeted the right HG at time 2 (i.e., 5.5–11 min) as a covariate and (right) the %RT change when 10 Hz-rTMS targeted the left HG at time 2 (i.e., 5.5–11 min) as a covariate. Three dimensional views were displayed by cutting sagittal slices through the left temporal cortex in order to focus on left temporal regions.
Mentions: We found a negative correlation between the %RT change caused by 10 Hz-rTMS targeting rHG and the functional interhemispheric connectivity between right and left auditory cortices, including bilateral STG, bilateral MTG and the left HG (see Figure 6A, left). This result shows that the higher the functional connectivity between left and right auditory cortices, the higher the facilitation (%RT decrease) caused by 10 Hz-rTMS over the right HG.

Bottom Line: However, not much is known about its effects on nonlinguistic auditory processing, especially its action on Heschl's gyrus (HG).TMS results showed that 10 Hz-rTMS targeting the right HG induced differential effects according to sex, with a facilitation of performance in females and an impairment of performance in males.We also found a differential correlation between the %RT change after 10 Hz-rTMS targeting the right HG and the interhemispheric functional connectivity between right and left HG, indicating that an increase in interhemispheric functional connectivity was associated with a facilitation of performance.

View Article: PubMed Central - PubMed

Affiliation: Montreal Neurological Institute, McGill University Montreal, QC, Canada.

ABSTRACT
Repetitive transcranial magnetic stimulation (rTMS) has been shown to interfere with many components of language processing, including semantic, syntactic, and phonologic. However, not much is known about its effects on nonlinguistic auditory processing, especially its action on Heschl's gyrus (HG). We aimed to investigate the behavioral and neural basis of rTMS during a melody processing task, while targeting the left HG, the right HG, and the Vertex as a control site. Response times (RT) were normalized relative to the baseline-rTMS (Vertex) and expressed as percentage change from baseline (%RT change). We also looked at sex differences in rTMS-induced response as well as in functional connectivity during melody processing using rTMS and functional magnetic resonance imaging (fMRI). fMRI results showed an increase in the right HG compared with the left HG during the melody task, as well as sex differences in functional connectivity indicating a greater interhemispheric connectivity between left and right HG in females compared with males. TMS results showed that 10 Hz-rTMS targeting the right HG induced differential effects according to sex, with a facilitation of performance in females and an impairment of performance in males. We also found a differential correlation between the %RT change after 10 Hz-rTMS targeting the right HG and the interhemispheric functional connectivity between right and left HG, indicating that an increase in interhemispheric functional connectivity was associated with a facilitation of performance. This is the first study to report a differential rTMS-induced interference with melody processing depending on sex. In addition, we showed a relationship between the interference induced by rTMS on behavioral performance and the neural activity in the network connecting left and right HG, suggesting that the interhemispheric functional connectivity could determine the degree of modulation of behavioral performance.

No MeSH data available.