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Interhemispheric Connectivity Influences the Degree of Modulation of TMS-Induced Effects during Auditory Processing.

Andoh J, Zatorre RJ - Front Psychol (2011)

Bottom Line: However, not much is known about its effects on nonlinguistic auditory processing, especially its action on Heschl's gyrus (HG).TMS results showed that 10 Hz-rTMS targeting the right HG induced differential effects according to sex, with a facilitation of performance in females and an impairment of performance in males.We also found a differential correlation between the %RT change after 10 Hz-rTMS targeting the right HG and the interhemispheric functional connectivity between right and left HG, indicating that an increase in interhemispheric functional connectivity was associated with a facilitation of performance.

View Article: PubMed Central - PubMed

Affiliation: Montreal Neurological Institute, McGill University Montreal, QC, Canada.

ABSTRACT
Repetitive transcranial magnetic stimulation (rTMS) has been shown to interfere with many components of language processing, including semantic, syntactic, and phonologic. However, not much is known about its effects on nonlinguistic auditory processing, especially its action on Heschl's gyrus (HG). We aimed to investigate the behavioral and neural basis of rTMS during a melody processing task, while targeting the left HG, the right HG, and the Vertex as a control site. Response times (RT) were normalized relative to the baseline-rTMS (Vertex) and expressed as percentage change from baseline (%RT change). We also looked at sex differences in rTMS-induced response as well as in functional connectivity during melody processing using rTMS and functional magnetic resonance imaging (fMRI). fMRI results showed an increase in the right HG compared with the left HG during the melody task, as well as sex differences in functional connectivity indicating a greater interhemispheric connectivity between left and right HG in females compared with males. TMS results showed that 10 Hz-rTMS targeting the right HG induced differential effects according to sex, with a facilitation of performance in females and an impairment of performance in males. We also found a differential correlation between the %RT change after 10 Hz-rTMS targeting the right HG and the interhemispheric functional connectivity between right and left HG, indicating that an increase in interhemispheric functional connectivity was associated with a facilitation of performance. This is the first study to report a differential rTMS-induced interference with melody processing depending on sex. In addition, we showed a relationship between the interference induced by rTMS on behavioral performance and the neural activity in the network connecting left and right HG, suggesting that the interhemispheric functional connectivity could determine the degree of modulation of behavioral performance.

No MeSH data available.


Group functional maps for the contrast of interest, i. e., melody discrimination minus auditory control. Increased task-related activity for the contrast resulting from the melody discrimination minus auditory control trials in (A) the female group (red-yellow) and (B) the male group (blue-lightblue; cluster-corrected p < 0.05, z = 2.3). (C) Between-group functional maps differences (z = 4). In red-yellow: increased task-related activity for the females compared with males; in blue-lightblue: increased task-related activity for the males compared with females (cluster-corrected p < 0.05, z = 1.6).
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Figure 3: Group functional maps for the contrast of interest, i. e., melody discrimination minus auditory control. Increased task-related activity for the contrast resulting from the melody discrimination minus auditory control trials in (A) the female group (red-yellow) and (B) the male group (blue-lightblue; cluster-corrected p < 0.05, z = 2.3). (C) Between-group functional maps differences (z = 4). In red-yellow: increased task-related activity for the females compared with males; in blue-lightblue: increased task-related activity for the males compared with females (cluster-corrected p < 0.05, z = 1.6).

Mentions: Within-group analysis showed that both female and male groups had task-related fMRI responses bilaterally, in the superior temporal gyri (STG), HG, inferior frontal gyri (IFG), and precentral gyri (Figures 3A,B; Table2). Between-group comparison differences of the functional maps showed that compared with males, females had higher task-related fMRI responses throughout auditory cortex: bilaterally in the STG, HG, and middle temporal gyri (MTG; Figure 3C).


Interhemispheric Connectivity Influences the Degree of Modulation of TMS-Induced Effects during Auditory Processing.

Andoh J, Zatorre RJ - Front Psychol (2011)

Group functional maps for the contrast of interest, i. e., melody discrimination minus auditory control. Increased task-related activity for the contrast resulting from the melody discrimination minus auditory control trials in (A) the female group (red-yellow) and (B) the male group (blue-lightblue; cluster-corrected p < 0.05, z = 2.3). (C) Between-group functional maps differences (z = 4). In red-yellow: increased task-related activity for the females compared with males; in blue-lightblue: increased task-related activity for the males compared with females (cluster-corrected p < 0.05, z = 1.6).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3139954&req=5

Figure 3: Group functional maps for the contrast of interest, i. e., melody discrimination minus auditory control. Increased task-related activity for the contrast resulting from the melody discrimination minus auditory control trials in (A) the female group (red-yellow) and (B) the male group (blue-lightblue; cluster-corrected p < 0.05, z = 2.3). (C) Between-group functional maps differences (z = 4). In red-yellow: increased task-related activity for the females compared with males; in blue-lightblue: increased task-related activity for the males compared with females (cluster-corrected p < 0.05, z = 1.6).
Mentions: Within-group analysis showed that both female and male groups had task-related fMRI responses bilaterally, in the superior temporal gyri (STG), HG, inferior frontal gyri (IFG), and precentral gyri (Figures 3A,B; Table2). Between-group comparison differences of the functional maps showed that compared with males, females had higher task-related fMRI responses throughout auditory cortex: bilaterally in the STG, HG, and middle temporal gyri (MTG; Figure 3C).

Bottom Line: However, not much is known about its effects on nonlinguistic auditory processing, especially its action on Heschl's gyrus (HG).TMS results showed that 10 Hz-rTMS targeting the right HG induced differential effects according to sex, with a facilitation of performance in females and an impairment of performance in males.We also found a differential correlation between the %RT change after 10 Hz-rTMS targeting the right HG and the interhemispheric functional connectivity between right and left HG, indicating that an increase in interhemispheric functional connectivity was associated with a facilitation of performance.

View Article: PubMed Central - PubMed

Affiliation: Montreal Neurological Institute, McGill University Montreal, QC, Canada.

ABSTRACT
Repetitive transcranial magnetic stimulation (rTMS) has been shown to interfere with many components of language processing, including semantic, syntactic, and phonologic. However, not much is known about its effects on nonlinguistic auditory processing, especially its action on Heschl's gyrus (HG). We aimed to investigate the behavioral and neural basis of rTMS during a melody processing task, while targeting the left HG, the right HG, and the Vertex as a control site. Response times (RT) were normalized relative to the baseline-rTMS (Vertex) and expressed as percentage change from baseline (%RT change). We also looked at sex differences in rTMS-induced response as well as in functional connectivity during melody processing using rTMS and functional magnetic resonance imaging (fMRI). fMRI results showed an increase in the right HG compared with the left HG during the melody task, as well as sex differences in functional connectivity indicating a greater interhemispheric connectivity between left and right HG in females compared with males. TMS results showed that 10 Hz-rTMS targeting the right HG induced differential effects according to sex, with a facilitation of performance in females and an impairment of performance in males. We also found a differential correlation between the %RT change after 10 Hz-rTMS targeting the right HG and the interhemispheric functional connectivity between right and left HG, indicating that an increase in interhemispheric functional connectivity was associated with a facilitation of performance. This is the first study to report a differential rTMS-induced interference with melody processing depending on sex. In addition, we showed a relationship between the interference induced by rTMS on behavioral performance and the neural activity in the network connecting left and right HG, suggesting that the interhemispheric functional connectivity could determine the degree of modulation of behavioral performance.

No MeSH data available.