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Cognitive-enhancing effect of quercetin in a rat model of Parkinson's disease induced by 6-hydroxydopamine.

Sriraksa N, Wattanathorn J, Muchimapura S, Tiamkao S, Brown K, Chaisiwamongkol K - Evid Based Complement Alternat Med (2011)

Bottom Line: In addition, the activity of acetylcholinesterase (AChE) was also measured.It was found that all doses of quercetin enhanced spatial memory.Therefore, it is suggested that the cognitive-enhancing effect of quercetin occurs partly because of decreased oxidative damage resulting in increased neuron density.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

ABSTRACT
Oxidative stress has been reported to induce cognitive impairment in Parkinson's disease. This paper aimed to determine the effect of quercetin, a substance possessing antioxidant activity, on the cognitive function in a rat model of Parkinson's disease. Male Wistar rats, weighing 200-250 g, were orally given quercetin at doses of 100, 200, 300 mg/kg BW once daily for a period of 14 days before and 14 days after the unilateral lesion of right substantia nigra induced by 6-hydroxydopamine (6-OHDA). Their spatial memory was assessed at 7 and 14 days of treatment and neuron density was determined, malondialdehyde (MDA) level, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were evaluated at the end of the experiment. In addition, the activity of acetylcholinesterase (AChE) was also measured. It was found that all doses of quercetin enhanced spatial memory. Therefore, it is suggested that the cognitive-enhancing effect of quercetin occurs partly because of decreased oxidative damage resulting in increased neuron density.

No MeSH data available.


Related in: MedlinePlus

Effect of quercetin on the level of malondialdehyde (MDA) in the hippocampus in an animal model of Parkinson's disease induced by 6-OHDA. Data were expressed as mean ± S.E.M. for 8 rats in each group.**P < 0.01 compared to control; #P < 0.05 compared to the vehicle + 6-OHDA-treated group.
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Related In: Results  -  Collection


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fig5: Effect of quercetin on the level of malondialdehyde (MDA) in the hippocampus in an animal model of Parkinson's disease induced by 6-OHDA. Data were expressed as mean ± S.E.M. for 8 rats in each group.**P < 0.01 compared to control; #P < 0.05 compared to the vehicle + 6-OHDA-treated group.

Mentions: The right hippocampus was isolated in order to determine MDA levels and scavenging enzyme activities. The results are shown in Figures 5, 6, 7, and 8. It was found that 6-OHDA injection significantly increased MDA level (P < 0.01 compared to control) but decreased the activity of GPx (P < 0.01 compared to control). Both positive-control-treated groups failed to show a significant reduction of MDA levels in the hippocampus while the high dose of quercetin used in this study significantly decreased MDA levels in the mentioned area (P < 0.05 compared to vehicle+6-OHDA). In addition, both L-dopa and vitamin C also increased the activities of SOD (P < 0.01 all, compared to vehicle+6-OHDA), GPx (P < 0.01 and 0.05 resp., compared to vehicle+6-OHDA). However, only rats subjected to L-dopa showed significantly increased CAT activity (P < 0.05 compared to vehicle+6-OHDA). Interestingly, it was found that the rats subjected to the high dose of quercetin had significantly enhanced SOD, CAT, and GPx activity in the hippocampus (P < 0.01, 0.01, and 0.05 resp., compared to vehicle+6-OHDA). The medium and low doses of quercetin-treated groups also had significantly increased GPx activity in the aforementioned area (P < 0.05 all, compared to vehicle+6-OHDA).


Cognitive-enhancing effect of quercetin in a rat model of Parkinson's disease induced by 6-hydroxydopamine.

Sriraksa N, Wattanathorn J, Muchimapura S, Tiamkao S, Brown K, Chaisiwamongkol K - Evid Based Complement Alternat Med (2011)

Effect of quercetin on the level of malondialdehyde (MDA) in the hippocampus in an animal model of Parkinson's disease induced by 6-OHDA. Data were expressed as mean ± S.E.M. for 8 rats in each group.**P < 0.01 compared to control; #P < 0.05 compared to the vehicle + 6-OHDA-treated group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3139913&req=5

fig5: Effect of quercetin on the level of malondialdehyde (MDA) in the hippocampus in an animal model of Parkinson's disease induced by 6-OHDA. Data were expressed as mean ± S.E.M. for 8 rats in each group.**P < 0.01 compared to control; #P < 0.05 compared to the vehicle + 6-OHDA-treated group.
Mentions: The right hippocampus was isolated in order to determine MDA levels and scavenging enzyme activities. The results are shown in Figures 5, 6, 7, and 8. It was found that 6-OHDA injection significantly increased MDA level (P < 0.01 compared to control) but decreased the activity of GPx (P < 0.01 compared to control). Both positive-control-treated groups failed to show a significant reduction of MDA levels in the hippocampus while the high dose of quercetin used in this study significantly decreased MDA levels in the mentioned area (P < 0.05 compared to vehicle+6-OHDA). In addition, both L-dopa and vitamin C also increased the activities of SOD (P < 0.01 all, compared to vehicle+6-OHDA), GPx (P < 0.01 and 0.05 resp., compared to vehicle+6-OHDA). However, only rats subjected to L-dopa showed significantly increased CAT activity (P < 0.05 compared to vehicle+6-OHDA). Interestingly, it was found that the rats subjected to the high dose of quercetin had significantly enhanced SOD, CAT, and GPx activity in the hippocampus (P < 0.01, 0.01, and 0.05 resp., compared to vehicle+6-OHDA). The medium and low doses of quercetin-treated groups also had significantly increased GPx activity in the aforementioned area (P < 0.05 all, compared to vehicle+6-OHDA).

Bottom Line: In addition, the activity of acetylcholinesterase (AChE) was also measured.It was found that all doses of quercetin enhanced spatial memory.Therefore, it is suggested that the cognitive-enhancing effect of quercetin occurs partly because of decreased oxidative damage resulting in increased neuron density.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

ABSTRACT
Oxidative stress has been reported to induce cognitive impairment in Parkinson's disease. This paper aimed to determine the effect of quercetin, a substance possessing antioxidant activity, on the cognitive function in a rat model of Parkinson's disease. Male Wistar rats, weighing 200-250 g, were orally given quercetin at doses of 100, 200, 300 mg/kg BW once daily for a period of 14 days before and 14 days after the unilateral lesion of right substantia nigra induced by 6-hydroxydopamine (6-OHDA). Their spatial memory was assessed at 7 and 14 days of treatment and neuron density was determined, malondialdehyde (MDA) level, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were evaluated at the end of the experiment. In addition, the activity of acetylcholinesterase (AChE) was also measured. It was found that all doses of quercetin enhanced spatial memory. Therefore, it is suggested that the cognitive-enhancing effect of quercetin occurs partly because of decreased oxidative damage resulting in increased neuron density.

No MeSH data available.


Related in: MedlinePlus