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Cognitive-enhancing effect of quercetin in a rat model of Parkinson's disease induced by 6-hydroxydopamine.

Sriraksa N, Wattanathorn J, Muchimapura S, Tiamkao S, Brown K, Chaisiwamongkol K - Evid Based Complement Alternat Med (2011)

Bottom Line: In addition, the activity of acetylcholinesterase (AChE) was also measured.It was found that all doses of quercetin enhanced spatial memory.Therefore, it is suggested that the cognitive-enhancing effect of quercetin occurs partly because of decreased oxidative damage resulting in increased neuron density.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

ABSTRACT
Oxidative stress has been reported to induce cognitive impairment in Parkinson's disease. This paper aimed to determine the effect of quercetin, a substance possessing antioxidant activity, on the cognitive function in a rat model of Parkinson's disease. Male Wistar rats, weighing 200-250 g, were orally given quercetin at doses of 100, 200, 300 mg/kg BW once daily for a period of 14 days before and 14 days after the unilateral lesion of right substantia nigra induced by 6-hydroxydopamine (6-OHDA). Their spatial memory was assessed at 7 and 14 days of treatment and neuron density was determined, malondialdehyde (MDA) level, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were evaluated at the end of the experiment. In addition, the activity of acetylcholinesterase (AChE) was also measured. It was found that all doses of quercetin enhanced spatial memory. Therefore, it is suggested that the cognitive-enhancing effect of quercetin occurs partly because of decreased oxidative damage resulting in increased neuron density.

No MeSH data available.


Related in: MedlinePlus

Effect of quercetin on escape latency in the Morris water maze test in an animal model of Parkinson's disease induced by 6-OHDA. Data were expressed as mean ± S.E.M. for 8 rats in each group. ***P < 0.001 compared to control; #P < 0.05; ##P < 0.01; ###P < 0.001 compared to the vehicle + 6-OHDA-treated group.
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fig1: Effect of quercetin on escape latency in the Morris water maze test in an animal model of Parkinson's disease induced by 6-OHDA. Data were expressed as mean ± S.E.M. for 8 rats in each group. ***P < 0.001 compared to control; #P < 0.05; ##P < 0.01; ###P < 0.001 compared to the vehicle + 6-OHDA-treated group.

Mentions: Cognitive impairment is commonly observed in Parkinson patients. Therefore, we examined the effect of quercetin on spatial memory by using the Morris water maze test and recorded escape latency and retention time as the indices. The results were shown in Figures 1 and 2. Figure 1 demonstrates that 6-OHDA injection significantly increased escape latency (P < 0.001 compared to control). Both L-dopa and vitamin C could decrease escape latency throughout the observation period (day 7: P < 0.001 and 0.01, respectively, compared to vehicle+6-OHDA; day 14: P < 0.001 all, compared to vehicle+6-OHDA). At the 7th day after lesion, all doses of quercetin (100, 200, and 300 mg/kg BW) used in this study significantly decreased the escape latency (P < 0.05, 0.01, and 0.001, resp., compared to vehicle+6-OHDA). The beneficial effect of quercetin to improve learning and memory was also observed throughout the 14-day period after lesion (P < 0.001 all, compared to vehicle+6-OHDA).


Cognitive-enhancing effect of quercetin in a rat model of Parkinson's disease induced by 6-hydroxydopamine.

Sriraksa N, Wattanathorn J, Muchimapura S, Tiamkao S, Brown K, Chaisiwamongkol K - Evid Based Complement Alternat Med (2011)

Effect of quercetin on escape latency in the Morris water maze test in an animal model of Parkinson's disease induced by 6-OHDA. Data were expressed as mean ± S.E.M. for 8 rats in each group. ***P < 0.001 compared to control; #P < 0.05; ##P < 0.01; ###P < 0.001 compared to the vehicle + 6-OHDA-treated group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3139913&req=5

fig1: Effect of quercetin on escape latency in the Morris water maze test in an animal model of Parkinson's disease induced by 6-OHDA. Data were expressed as mean ± S.E.M. for 8 rats in each group. ***P < 0.001 compared to control; #P < 0.05; ##P < 0.01; ###P < 0.001 compared to the vehicle + 6-OHDA-treated group.
Mentions: Cognitive impairment is commonly observed in Parkinson patients. Therefore, we examined the effect of quercetin on spatial memory by using the Morris water maze test and recorded escape latency and retention time as the indices. The results were shown in Figures 1 and 2. Figure 1 demonstrates that 6-OHDA injection significantly increased escape latency (P < 0.001 compared to control). Both L-dopa and vitamin C could decrease escape latency throughout the observation period (day 7: P < 0.001 and 0.01, respectively, compared to vehicle+6-OHDA; day 14: P < 0.001 all, compared to vehicle+6-OHDA). At the 7th day after lesion, all doses of quercetin (100, 200, and 300 mg/kg BW) used in this study significantly decreased the escape latency (P < 0.05, 0.01, and 0.001, resp., compared to vehicle+6-OHDA). The beneficial effect of quercetin to improve learning and memory was also observed throughout the 14-day period after lesion (P < 0.001 all, compared to vehicle+6-OHDA).

Bottom Line: In addition, the activity of acetylcholinesterase (AChE) was also measured.It was found that all doses of quercetin enhanced spatial memory.Therefore, it is suggested that the cognitive-enhancing effect of quercetin occurs partly because of decreased oxidative damage resulting in increased neuron density.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

ABSTRACT
Oxidative stress has been reported to induce cognitive impairment in Parkinson's disease. This paper aimed to determine the effect of quercetin, a substance possessing antioxidant activity, on the cognitive function in a rat model of Parkinson's disease. Male Wistar rats, weighing 200-250 g, were orally given quercetin at doses of 100, 200, 300 mg/kg BW once daily for a period of 14 days before and 14 days after the unilateral lesion of right substantia nigra induced by 6-hydroxydopamine (6-OHDA). Their spatial memory was assessed at 7 and 14 days of treatment and neuron density was determined, malondialdehyde (MDA) level, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were evaluated at the end of the experiment. In addition, the activity of acetylcholinesterase (AChE) was also measured. It was found that all doses of quercetin enhanced spatial memory. Therefore, it is suggested that the cognitive-enhancing effect of quercetin occurs partly because of decreased oxidative damage resulting in increased neuron density.

No MeSH data available.


Related in: MedlinePlus