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Optical coherence tomography of retinal and choroidal tumors.

Say EA, Shah SU, Ferenczy S, Shields CL - J Ophthalmol (2011)

Bottom Line: In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture.Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment.Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

View Article: PubMed Central - PubMed

Affiliation: Oncology Service, Wills Eye Institute, Thomas Jefferson University, Suite 1440, 840 Walnut Street, Philadelphia, PA 19107, USA.

ABSTRACT
Optical coherence tomography (OCT) has revolutionized the field of ophthalmology since its introduction 20 years ago. Originally intended primarily for retina specialists to image the macula, it has found its role in other subspecialties that include glaucoma, cornea, and ocular oncology. In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture. Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment. With more advanced technology, OCT now provides imaging deeper into the choroid using a technique called enhanced depth imaging. This allows characterization of the thickness and reflective quality of small (<3 mm thick) choroidal lesions including choroidal nevus and melanoma. Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

No MeSH data available.


Related in: MedlinePlus

Vasoproliferative tumor. (a) Vasoproliferative tumor located at inferior periphery with preretinal fibrosis at its superior border and yellow subretinal fibrosis nasally. (b) Time domain OCT reveals a hyperreflective and disorganized inner retina with shadowing of the posterior layers including the RPE. An epiretinal membrane is seen at its posterior border.
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fig13: Vasoproliferative tumor. (a) Vasoproliferative tumor located at inferior periphery with preretinal fibrosis at its superior border and yellow subretinal fibrosis nasally. (b) Time domain OCT reveals a hyperreflective and disorganized inner retina with shadowing of the posterior layers including the RPE. An epiretinal membrane is seen at its posterior border.

Mentions: Inner retinal layer disorganization and posterior shadowing are features of vasoproliferative tumors on OCT [63] (Figure 13). They are difficult to image with OCT due to their peripheral location, but newer machines with longer scan lengths may be useful. OCT is beneficial for detecting associated preretinal fibrosis, macular edema, and subretinal fluid, as well as monitoring treatment [64].


Optical coherence tomography of retinal and choroidal tumors.

Say EA, Shah SU, Ferenczy S, Shields CL - J Ophthalmol (2011)

Vasoproliferative tumor. (a) Vasoproliferative tumor located at inferior periphery with preretinal fibrosis at its superior border and yellow subretinal fibrosis nasally. (b) Time domain OCT reveals a hyperreflective and disorganized inner retina with shadowing of the posterior layers including the RPE. An epiretinal membrane is seen at its posterior border.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3139893&req=5

fig13: Vasoproliferative tumor. (a) Vasoproliferative tumor located at inferior periphery with preretinal fibrosis at its superior border and yellow subretinal fibrosis nasally. (b) Time domain OCT reveals a hyperreflective and disorganized inner retina with shadowing of the posterior layers including the RPE. An epiretinal membrane is seen at its posterior border.
Mentions: Inner retinal layer disorganization and posterior shadowing are features of vasoproliferative tumors on OCT [63] (Figure 13). They are difficult to image with OCT due to their peripheral location, but newer machines with longer scan lengths may be useful. OCT is beneficial for detecting associated preretinal fibrosis, macular edema, and subretinal fluid, as well as monitoring treatment [64].

Bottom Line: In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture.Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment.Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

View Article: PubMed Central - PubMed

Affiliation: Oncology Service, Wills Eye Institute, Thomas Jefferson University, Suite 1440, 840 Walnut Street, Philadelphia, PA 19107, USA.

ABSTRACT
Optical coherence tomography (OCT) has revolutionized the field of ophthalmology since its introduction 20 years ago. Originally intended primarily for retina specialists to image the macula, it has found its role in other subspecialties that include glaucoma, cornea, and ocular oncology. In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture. Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment. With more advanced technology, OCT now provides imaging deeper into the choroid using a technique called enhanced depth imaging. This allows characterization of the thickness and reflective quality of small (<3 mm thick) choroidal lesions including choroidal nevus and melanoma. Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

No MeSH data available.


Related in: MedlinePlus