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Optical coherence tomography of retinal and choroidal tumors.

Say EA, Shah SU, Ferenczy S, Shields CL - J Ophthalmol (2011)

Bottom Line: In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture.Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment.Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

View Article: PubMed Central - PubMed

Affiliation: Oncology Service, Wills Eye Institute, Thomas Jefferson University, Suite 1440, 840 Walnut Street, Philadelphia, PA 19107, USA.

ABSTRACT
Optical coherence tomography (OCT) has revolutionized the field of ophthalmology since its introduction 20 years ago. Originally intended primarily for retina specialists to image the macula, it has found its role in other subspecialties that include glaucoma, cornea, and ocular oncology. In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture. Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment. With more advanced technology, OCT now provides imaging deeper into the choroid using a technique called enhanced depth imaging. This allows characterization of the thickness and reflective quality of small (<3 mm thick) choroidal lesions including choroidal nevus and melanoma. Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

No MeSH data available.


Related in: MedlinePlus

Retinal astrocytic hamartoma. (a) Juxtapapillary retinal astrocytic hamartoma with preretinal fibrosis and nasal dragging of the macula. (b) Spectral domain OCT image exhibits disorganization of the inner retinal layers and an intact RPE underlying the tumor. There is posterior shadowing presumably from calcification of the tumor apex. A dense epiretinal membrane causes the traction of the adjacent normal retina.
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fig10: Retinal astrocytic hamartoma. (a) Juxtapapillary retinal astrocytic hamartoma with preretinal fibrosis and nasal dragging of the macula. (b) Spectral domain OCT image exhibits disorganization of the inner retinal layers and an intact RPE underlying the tumor. There is posterior shadowing presumably from calcification of the tumor apex. A dense epiretinal membrane causes the traction of the adjacent normal retina.

Mentions: Astrocytic hamartomas show inner retinal thickening and disorganization with a gradual transition to the adjacent normal retina [5, 54] (Figure 10). Calcified tumors have higher reflectivity and greater posterior shadowing, while noncalcified tumors allow some light transmission to demonstrate intact outer retinal layers [54, 55]. There may be associated retinal traction in 27%, an intrinsic moth-eaten appearance from intratumoral cysts in 67%, and adjacent retinal or macular edema in 47% [54]. When treatment is initiated for macular edema, OCT may be used to follow resolution of subretinal fluid or release of macular traction [56, 57]. High-resolution spectral domain OCT confirms the intact outer retinal structures, as well as the underlying choriocapillaris [58]. 3D reconstruction demonstrates tumor architecture and its relationship to the adjacent retina in a single image [58].


Optical coherence tomography of retinal and choroidal tumors.

Say EA, Shah SU, Ferenczy S, Shields CL - J Ophthalmol (2011)

Retinal astrocytic hamartoma. (a) Juxtapapillary retinal astrocytic hamartoma with preretinal fibrosis and nasal dragging of the macula. (b) Spectral domain OCT image exhibits disorganization of the inner retinal layers and an intact RPE underlying the tumor. There is posterior shadowing presumably from calcification of the tumor apex. A dense epiretinal membrane causes the traction of the adjacent normal retina.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3139893&req=5

fig10: Retinal astrocytic hamartoma. (a) Juxtapapillary retinal astrocytic hamartoma with preretinal fibrosis and nasal dragging of the macula. (b) Spectral domain OCT image exhibits disorganization of the inner retinal layers and an intact RPE underlying the tumor. There is posterior shadowing presumably from calcification of the tumor apex. A dense epiretinal membrane causes the traction of the adjacent normal retina.
Mentions: Astrocytic hamartomas show inner retinal thickening and disorganization with a gradual transition to the adjacent normal retina [5, 54] (Figure 10). Calcified tumors have higher reflectivity and greater posterior shadowing, while noncalcified tumors allow some light transmission to demonstrate intact outer retinal layers [54, 55]. There may be associated retinal traction in 27%, an intrinsic moth-eaten appearance from intratumoral cysts in 67%, and adjacent retinal or macular edema in 47% [54]. When treatment is initiated for macular edema, OCT may be used to follow resolution of subretinal fluid or release of macular traction [56, 57]. High-resolution spectral domain OCT confirms the intact outer retinal structures, as well as the underlying choriocapillaris [58]. 3D reconstruction demonstrates tumor architecture and its relationship to the adjacent retina in a single image [58].

Bottom Line: In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture.Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment.Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

View Article: PubMed Central - PubMed

Affiliation: Oncology Service, Wills Eye Institute, Thomas Jefferson University, Suite 1440, 840 Walnut Street, Philadelphia, PA 19107, USA.

ABSTRACT
Optical coherence tomography (OCT) has revolutionized the field of ophthalmology since its introduction 20 years ago. Originally intended primarily for retina specialists to image the macula, it has found its role in other subspecialties that include glaucoma, cornea, and ocular oncology. In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture. Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment. With more advanced technology, OCT now provides imaging deeper into the choroid using a technique called enhanced depth imaging. This allows characterization of the thickness and reflective quality of small (<3 mm thick) choroidal lesions including choroidal nevus and melanoma. Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

No MeSH data available.


Related in: MedlinePlus