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Optical coherence tomography of retinal and choroidal tumors.

Say EA, Shah SU, Ferenczy S, Shields CL - J Ophthalmol (2011)

Bottom Line: In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture.Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment.Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

View Article: PubMed Central - PubMed

Affiliation: Oncology Service, Wills Eye Institute, Thomas Jefferson University, Suite 1440, 840 Walnut Street, Philadelphia, PA 19107, USA.

ABSTRACT
Optical coherence tomography (OCT) has revolutionized the field of ophthalmology since its introduction 20 years ago. Originally intended primarily for retina specialists to image the macula, it has found its role in other subspecialties that include glaucoma, cornea, and ocular oncology. In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture. Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment. With more advanced technology, OCT now provides imaging deeper into the choroid using a technique called enhanced depth imaging. This allows characterization of the thickness and reflective quality of small (<3 mm thick) choroidal lesions including choroidal nevus and melanoma. Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

No MeSH data available.


Related in: MedlinePlus

Retinoblastoma. (a) Mostly calcified retinoblastoma following chemoreduction and consolidation. (b) Time domain OCT demonstrates disorganization and irregularity of the inner retinal layers and posterior shadowing from calcification.
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fig9: Retinoblastoma. (a) Mostly calcified retinoblastoma following chemoreduction and consolidation. (b) Time domain OCT demonstrates disorganization and irregularity of the inner retinal layers and posterior shadowing from calcification.

Mentions: Individual retinoblastoma tumors appear on OCT as thickening and disorganization of the neurosensory retina with posterior shadowing possibly from inherent calcification [5] (Figure 9). Associated subretinal fluid or intraretinal cysts are clearly visualized on OCT when present [5, 50]. The role of OCT lies in its ability to image the macula, particularly the fovea. This is important in children with retinoblastoma, since restoration of normal foveal anatomy may be achieved following treatment [51]. Further, differentiation from an organic (i.e., macular edema and loss of photoreceptors) versus a nonorganic (i.e., amblyopia) cause of vision loss is essential to plan for long-term visual rehabilitation and maximizing outcome in all patients.


Optical coherence tomography of retinal and choroidal tumors.

Say EA, Shah SU, Ferenczy S, Shields CL - J Ophthalmol (2011)

Retinoblastoma. (a) Mostly calcified retinoblastoma following chemoreduction and consolidation. (b) Time domain OCT demonstrates disorganization and irregularity of the inner retinal layers and posterior shadowing from calcification.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3139893&req=5

fig9: Retinoblastoma. (a) Mostly calcified retinoblastoma following chemoreduction and consolidation. (b) Time domain OCT demonstrates disorganization and irregularity of the inner retinal layers and posterior shadowing from calcification.
Mentions: Individual retinoblastoma tumors appear on OCT as thickening and disorganization of the neurosensory retina with posterior shadowing possibly from inherent calcification [5] (Figure 9). Associated subretinal fluid or intraretinal cysts are clearly visualized on OCT when present [5, 50]. The role of OCT lies in its ability to image the macula, particularly the fovea. This is important in children with retinoblastoma, since restoration of normal foveal anatomy may be achieved following treatment [51]. Further, differentiation from an organic (i.e., macular edema and loss of photoreceptors) versus a nonorganic (i.e., amblyopia) cause of vision loss is essential to plan for long-term visual rehabilitation and maximizing outcome in all patients.

Bottom Line: In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture.Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment.Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

View Article: PubMed Central - PubMed

Affiliation: Oncology Service, Wills Eye Institute, Thomas Jefferson University, Suite 1440, 840 Walnut Street, Philadelphia, PA 19107, USA.

ABSTRACT
Optical coherence tomography (OCT) has revolutionized the field of ophthalmology since its introduction 20 years ago. Originally intended primarily for retina specialists to image the macula, it has found its role in other subspecialties that include glaucoma, cornea, and ocular oncology. In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture. Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment. With more advanced technology, OCT now provides imaging deeper into the choroid using a technique called enhanced depth imaging. This allows characterization of the thickness and reflective quality of small (<3 mm thick) choroidal lesions including choroidal nevus and melanoma. Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

No MeSH data available.


Related in: MedlinePlus