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Optical coherence tomography of retinal and choroidal tumors.

Say EA, Shah SU, Ferenczy S, Shields CL - J Ophthalmol (2011)

Bottom Line: In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture.Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment.Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

View Article: PubMed Central - PubMed

Affiliation: Oncology Service, Wills Eye Institute, Thomas Jefferson University, Suite 1440, 840 Walnut Street, Philadelphia, PA 19107, USA.

ABSTRACT
Optical coherence tomography (OCT) has revolutionized the field of ophthalmology since its introduction 20 years ago. Originally intended primarily for retina specialists to image the macula, it has found its role in other subspecialties that include glaucoma, cornea, and ocular oncology. In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture. Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment. With more advanced technology, OCT now provides imaging deeper into the choroid using a technique called enhanced depth imaging. This allows characterization of the thickness and reflective quality of small (<3 mm thick) choroidal lesions including choroidal nevus and melanoma. Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

No MeSH data available.


Related in: MedlinePlus

Choroidal metastasis. (a) Amelanotic choroidal metastasis in a patient with breast cancer. (b) EDI OCT reveals both the anterior and posterior margins of the metastasis allowing measurement of tumor thickness and characterization of its internal structure. Multiple nodular elevations of the RPE can also be seen with thickening of the RPE, overlying subretinal fluid, and hyperreflective deposits within the neurosensory detachments presumably from tumor cells or macrophages.
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fig3: Choroidal metastasis. (a) Amelanotic choroidal metastasis in a patient with breast cancer. (b) EDI OCT reveals both the anterior and posterior margins of the metastasis allowing measurement of tumor thickness and characterization of its internal structure. Multiple nodular elevations of the RPE can also be seen with thickening of the RPE, overlying subretinal fluid, and hyperreflective deposits within the neurosensory detachments presumably from tumor cells or macrophages.

Mentions: OCT of choroidal metastasis demonstrates a dome-shaped elevation of the neurosensory retina and RPE with adjacent subretinal fluid (Figure 3). It can also be associated with retinal edema, intraretinal cysts, and thickening and detachment of the RPE. Natesh and associates found highly reflective subretinal deposits corresponding to RPE clumping overlying the tumor on clinical examination [24]. Arevalo and colleagues also found highly reflective points within neurosensory detachment in 14.2% of cases and concluded that these points “may correspond to retinal compromise by cancer cells or macrophages containing lipofuscin and melanin granules” [25]. Choroidal features are also limited to the anterior surface as with all choroidal tumors, and they often have variable reflectivity [10]. In addition to its diagnostic capabilities, OCT is valuable in monitoring treatment response, since resolution of subretinal fluid and return of normal retinal architecture has been documented following therapy [25, 26].


Optical coherence tomography of retinal and choroidal tumors.

Say EA, Shah SU, Ferenczy S, Shields CL - J Ophthalmol (2011)

Choroidal metastasis. (a) Amelanotic choroidal metastasis in a patient with breast cancer. (b) EDI OCT reveals both the anterior and posterior margins of the metastasis allowing measurement of tumor thickness and characterization of its internal structure. Multiple nodular elevations of the RPE can also be seen with thickening of the RPE, overlying subretinal fluid, and hyperreflective deposits within the neurosensory detachments presumably from tumor cells or macrophages.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3139893&req=5

fig3: Choroidal metastasis. (a) Amelanotic choroidal metastasis in a patient with breast cancer. (b) EDI OCT reveals both the anterior and posterior margins of the metastasis allowing measurement of tumor thickness and characterization of its internal structure. Multiple nodular elevations of the RPE can also be seen with thickening of the RPE, overlying subretinal fluid, and hyperreflective deposits within the neurosensory detachments presumably from tumor cells or macrophages.
Mentions: OCT of choroidal metastasis demonstrates a dome-shaped elevation of the neurosensory retina and RPE with adjacent subretinal fluid (Figure 3). It can also be associated with retinal edema, intraretinal cysts, and thickening and detachment of the RPE. Natesh and associates found highly reflective subretinal deposits corresponding to RPE clumping overlying the tumor on clinical examination [24]. Arevalo and colleagues also found highly reflective points within neurosensory detachment in 14.2% of cases and concluded that these points “may correspond to retinal compromise by cancer cells or macrophages containing lipofuscin and melanin granules” [25]. Choroidal features are also limited to the anterior surface as with all choroidal tumors, and they often have variable reflectivity [10]. In addition to its diagnostic capabilities, OCT is valuable in monitoring treatment response, since resolution of subretinal fluid and return of normal retinal architecture has been documented following therapy [25, 26].

Bottom Line: In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture.Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment.Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

View Article: PubMed Central - PubMed

Affiliation: Oncology Service, Wills Eye Institute, Thomas Jefferson University, Suite 1440, 840 Walnut Street, Philadelphia, PA 19107, USA.

ABSTRACT
Optical coherence tomography (OCT) has revolutionized the field of ophthalmology since its introduction 20 years ago. Originally intended primarily for retina specialists to image the macula, it has found its role in other subspecialties that include glaucoma, cornea, and ocular oncology. In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture. Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment. With more advanced technology, OCT now provides imaging deeper into the choroid using a technique called enhanced depth imaging. This allows characterization of the thickness and reflective quality of small (<3 mm thick) choroidal lesions including choroidal nevus and melanoma. Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

No MeSH data available.


Related in: MedlinePlus