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Askin's Tumor: A Dual Case Study.

Shrestha B, Kapur BN, Karmacharya K, Kakkar S, Ghuliani R - Int J Pediatr (2011)

Bottom Line: Askin's tumor is a rare tumor arising from the chest wall.It is a subset of Ewing sarcoma characterized histologically by the presence of small round blue cells.A dual paper of Askin's tumors in young boys is being presented here.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Armed Forces Medical College, Pune, India.

ABSTRACT
Askin's tumor is a rare tumor arising from the chest wall. It is a subset of Ewing sarcoma characterized histologically by the presence of small round blue cells. It is a highly malignant tumor with guarded prognosis, which is dependent upon the extension of tumor at the time of diagnosis. A dual paper of Askin's tumors in young boys is being presented here.

No MeSH data available.


Related in: MedlinePlus

FNAC from the lesion in Case 1 showing the small round blue cells (×400 magnification).
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Related In: Results  -  Collection


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fig2: FNAC from the lesion in Case 1 showing the small round blue cells (×400 magnification).

Mentions: 3 years old male toddler, presented with 15 days of cough and 1 day of chest pain, breathlessness, and low-grade fever. He had no other associated complaints, and his past history was unremarkable. Chest radiograph PA view showed a large homogenous opacity on right upper lobe, suggestive of a mass lesion (Figure 1). CT scan revealed a large mass (6.1 cm × 5.6 cm × 5.1 cm) which was merging medially with the mediastinum and laterally, anteriorly, posteriorly and superiorly with the thoracic wall, involving posterior and lateral parts of right 1st and 2nd ribs. Fine needle aspiration cytology (FNAC) from the mass lesion showed small blue round cells with monomorphous salt and pepper appearing chromatin and large and inconspicuous nuclei, suggestive of primitive neuroectodermal tumor—likely Askin's tumor (Figure 2). For diagnostic consideration, biopsy was taken from the mass. It revealed small cells with large nuclei and scanty cytoplasm, with regular chromatin and inconspicuous nucleoli. Considering the site and histology, diagnosis of Askin's tumor was made. He was started chemotherapy with vincristine, adriamycin and cyclophosphamide (VAC), and Ifosfamide and etoposide (IE) alternating 3 weekly cycles as per round cell tumor II (RCT II) protocol [3].


Askin's Tumor: A Dual Case Study.

Shrestha B, Kapur BN, Karmacharya K, Kakkar S, Ghuliani R - Int J Pediatr (2011)

FNAC from the lesion in Case 1 showing the small round blue cells (×400 magnification).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3139879&req=5

fig2: FNAC from the lesion in Case 1 showing the small round blue cells (×400 magnification).
Mentions: 3 years old male toddler, presented with 15 days of cough and 1 day of chest pain, breathlessness, and low-grade fever. He had no other associated complaints, and his past history was unremarkable. Chest radiograph PA view showed a large homogenous opacity on right upper lobe, suggestive of a mass lesion (Figure 1). CT scan revealed a large mass (6.1 cm × 5.6 cm × 5.1 cm) which was merging medially with the mediastinum and laterally, anteriorly, posteriorly and superiorly with the thoracic wall, involving posterior and lateral parts of right 1st and 2nd ribs. Fine needle aspiration cytology (FNAC) from the mass lesion showed small blue round cells with monomorphous salt and pepper appearing chromatin and large and inconspicuous nuclei, suggestive of primitive neuroectodermal tumor—likely Askin's tumor (Figure 2). For diagnostic consideration, biopsy was taken from the mass. It revealed small cells with large nuclei and scanty cytoplasm, with regular chromatin and inconspicuous nucleoli. Considering the site and histology, diagnosis of Askin's tumor was made. He was started chemotherapy with vincristine, adriamycin and cyclophosphamide (VAC), and Ifosfamide and etoposide (IE) alternating 3 weekly cycles as per round cell tumor II (RCT II) protocol [3].

Bottom Line: Askin's tumor is a rare tumor arising from the chest wall.It is a subset of Ewing sarcoma characterized histologically by the presence of small round blue cells.A dual paper of Askin's tumors in young boys is being presented here.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Armed Forces Medical College, Pune, India.

ABSTRACT
Askin's tumor is a rare tumor arising from the chest wall. It is a subset of Ewing sarcoma characterized histologically by the presence of small round blue cells. It is a highly malignant tumor with guarded prognosis, which is dependent upon the extension of tumor at the time of diagnosis. A dual paper of Askin's tumors in young boys is being presented here.

No MeSH data available.


Related in: MedlinePlus