DCDC2, KIAA0319 and CMIP are associated with reading-related traits.
Bottom Line: We show that DCDC2 is specifically associated with RD, whereas variants in CMIP and KIAA0319 are associated with reading skills across the ability range.The strongest associations were restricted to single-word reading and spelling measures, suggesting that these genes do not extend their effect to other reading and language-related skills.Our data do not support MRPL19/C2ORF3 as a locus involved in reading abilities nor CMIP/ATP2C2 as genes regulating language skills.
Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, UK.Show MeSH
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Mentions: The ALSPAC children were assigned to one of eight affection status subgroups (Methods in Supplement 1); unaffected, RD, SLI, ADHD, or one of the four comorbid combinations (Figure 2, Table 1). From the initial sample, we filtered sequentially for missing data, ethnicity, performance IQ, and signs of autism, selecting 3725 individuals to calculate disorder prevalences. The prevalence of RD (6.04%) and SLI (6.44%) in this subgroup of the ALSPAC cohort is comparable to other studies (2,58), and the prevalence of ADHD (1.05%) is lower than previous reports of approximately 5% (59). The low prevalence of ADHD is explained primarily by a conservative assignment criterion but a specific dropout of children with ADHD from the ALSPAC study has also been suggested (60). Levels of comorbidity (Table 1) were comparable to other studies (1,9), but our conservative criterion for ADHD would have an impact on the rates of comorbidity with ADHD in this sample.
Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, UK.