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Antibodies that induce phagocytosis of malaria infected erythrocytes: effect of HIV infection and correlation with clinical outcomes.

Ataíde R, Mwapasa V, Molyneux ME, Meshnick SR, Rogerson SJ - PLoS ONE (2011)

Bottom Line: We measured total IgG and phagocytic antibodies against variant surface antigens of placental-type CS2 parasites in 187 secundigravidae (65% HIV infected).In women with placental malaria infection, phagocytic antibodies to CS2(VSA) were decreased in the presence of HIV (p = 0.011) and correlated positively with infant birth weight (coef = 3.57, p = 0.025), whereas total IgG to CS2(VSA) did not.Secundigravidae may be an informative group for identification of correlates of immunity.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine (RMH/WH), University of Melbourne, Post Office Royal Melbourne Hospital, Melbourne, Victoria, Australia. ric.ataide@gmail.com

ABSTRACT
HIV infection increases the burden of disease of malaria in pregnancy, in part by impairing the development of immunity. We measured total IgG and phagocytic antibodies against variant surface antigens of placental-type CS2 parasites in 187 secundigravidae (65% HIV infected). In women with placental malaria infection, phagocytic antibodies to CS2(VSA) were decreased in the presence of HIV (p = 0.011) and correlated positively with infant birth weight (coef = 3.57, p = 0.025), whereas total IgG to CS2(VSA) did not. Phagocytic antibodies to CS2(VSA) are valuable tools to study acquired immunity to malaria in the context of HIV co-infection. Secundigravidae may be an informative group for identification of correlates of immunity.

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Related in: MedlinePlus

Effect of HIV on the anti-CS2VSA antibody levels in the ‘No Malaria’ histopathology group.In a univariate analysis of women that showed no evidence of either peripheral or placental malaria infection, using Mann-Whitney ranksum tests, phagocytic antibodies (A) are shown to be significantly decreased by HIV infection (z = −2.17, p = 0.03). On the contrary total IgG to CS2VSA (B) shows a non-significant decrease in the HIV-positive group (z = −1.35, p = 0.179. Box, median and interquartile range; whiskers, lowest and highest values. P values are shown.
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pone-0022491-g002: Effect of HIV on the anti-CS2VSA antibody levels in the ‘No Malaria’ histopathology group.In a univariate analysis of women that showed no evidence of either peripheral or placental malaria infection, using Mann-Whitney ranksum tests, phagocytic antibodies (A) are shown to be significantly decreased by HIV infection (z = −2.17, p = 0.03). On the contrary total IgG to CS2VSA (B) shows a non-significant decrease in the HIV-positive group (z = −1.35, p = 0.179. Box, median and interquartile range; whiskers, lowest and highest values. P values are shown.

Mentions: In women belonging to the histopathology group ‘No Malaria’ (where no evidence of either peripheral or placental malaria was detected) sufficient numbers were available for an analysis of the effect of HIV (n = 109). HIV significantly affected the function of phagocytic antibodies (z = −2.17, P = 0.03) (Figure 2A), but not the total IgG to CS2VSA (Z = −1.35, P = 0.179) (Figure 2B).


Antibodies that induce phagocytosis of malaria infected erythrocytes: effect of HIV infection and correlation with clinical outcomes.

Ataíde R, Mwapasa V, Molyneux ME, Meshnick SR, Rogerson SJ - PLoS ONE (2011)

Effect of HIV on the anti-CS2VSA antibody levels in the ‘No Malaria’ histopathology group.In a univariate analysis of women that showed no evidence of either peripheral or placental malaria infection, using Mann-Whitney ranksum tests, phagocytic antibodies (A) are shown to be significantly decreased by HIV infection (z = −2.17, p = 0.03). On the contrary total IgG to CS2VSA (B) shows a non-significant decrease in the HIV-positive group (z = −1.35, p = 0.179. Box, median and interquartile range; whiskers, lowest and highest values. P values are shown.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3139654&req=5

pone-0022491-g002: Effect of HIV on the anti-CS2VSA antibody levels in the ‘No Malaria’ histopathology group.In a univariate analysis of women that showed no evidence of either peripheral or placental malaria infection, using Mann-Whitney ranksum tests, phagocytic antibodies (A) are shown to be significantly decreased by HIV infection (z = −2.17, p = 0.03). On the contrary total IgG to CS2VSA (B) shows a non-significant decrease in the HIV-positive group (z = −1.35, p = 0.179. Box, median and interquartile range; whiskers, lowest and highest values. P values are shown.
Mentions: In women belonging to the histopathology group ‘No Malaria’ (where no evidence of either peripheral or placental malaria was detected) sufficient numbers were available for an analysis of the effect of HIV (n = 109). HIV significantly affected the function of phagocytic antibodies (z = −2.17, P = 0.03) (Figure 2A), but not the total IgG to CS2VSA (Z = −1.35, P = 0.179) (Figure 2B).

Bottom Line: We measured total IgG and phagocytic antibodies against variant surface antigens of placental-type CS2 parasites in 187 secundigravidae (65% HIV infected).In women with placental malaria infection, phagocytic antibodies to CS2(VSA) were decreased in the presence of HIV (p = 0.011) and correlated positively with infant birth weight (coef = 3.57, p = 0.025), whereas total IgG to CS2(VSA) did not.Secundigravidae may be an informative group for identification of correlates of immunity.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine (RMH/WH), University of Melbourne, Post Office Royal Melbourne Hospital, Melbourne, Victoria, Australia. ric.ataide@gmail.com

ABSTRACT
HIV infection increases the burden of disease of malaria in pregnancy, in part by impairing the development of immunity. We measured total IgG and phagocytic antibodies against variant surface antigens of placental-type CS2 parasites in 187 secundigravidae (65% HIV infected). In women with placental malaria infection, phagocytic antibodies to CS2(VSA) were decreased in the presence of HIV (p = 0.011) and correlated positively with infant birth weight (coef = 3.57, p = 0.025), whereas total IgG to CS2(VSA) did not. Phagocytic antibodies to CS2(VSA) are valuable tools to study acquired immunity to malaria in the context of HIV co-infection. Secundigravidae may be an informative group for identification of correlates of immunity.

Show MeSH
Related in: MedlinePlus