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Genetic switch underlies C. albicans quick change act.

Vance E - PLoS Biol. (2011)

View Article: PubMed Central - PubMed

Affiliation: Mexico City, Mexico.

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In the yeast form, it is not terribly dangerous but is highly mobile, hitching a ride in blood flows or other body processes... The hypha form spreads faster, given its filamentous-like nature, but cannot, for example, move into the bloodstream, and its ill-effects are limited... Sometimes the fungi will even switch as self-defense, using hyphal structures to fend off attackers... As a result, scientists have long tried to understand the mechanisms that allow C. albicans to quickly slip between hypha and yeast phase... A team at the University of California Irvine has painstakingly narrowed down the process to a series of two sequential genetic triggers that give this fungus its unique advantage... First, they found that the primary obstacle to a swift yeast-hypha switch is a protein that inhibits transcription called Nrg1... The team found that before C. albicans transitions into the hyphal stage, it expunges Nrg1 by activating a major growth signaling pathway called cAMP-PKA... After the Nrg1 was evacuated, the cell began to change its shape as well as its transcriptional program... But in order to prevent Nrg1 from returning to its position on the DNA—and keep the transition process moving without interruption—another protein, called Hda1, was recruited to maintain transcription and prevent the Nrg1 from binding to DNA... The authors demonstrate this model by creating mutant strains of C. albicans that could not produce Hda1 and thus were unable to complete the transition to the hyphal stage, despite the conditions being otherwise perfect (many things can induce a change, but the team used the most reliable—raising the temperature to 37°C and mixing in blood serum)... The team also found that for a successful transition to hyphae, the yeast required rich, nutrient-packed media and that in nutrient-poor media, the hyphae simply stayed hyphae... It also may aid in finding new treatments for diseases related to C. albicans if scientists could find a way to trap the fungus in its yeast form.

No MeSH data available.


Related in: MedlinePlus

New research supports a new model to explain how C. albicans, the most common cause of invasive fungal infections in humans, manages the morphological plasticity necessary for pathogenesis.
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getmorefigures.php?uid=PMC3139635&req=5

pbio-1001108-g001: New research supports a new model to explain how C. albicans, the most common cause of invasive fungal infections in humans, manages the morphological plasticity necessary for pathogenesis.

Mentions: In the fungus world, just as in the business one, the key to success is flexibility. A fungus that can adapt and change to its environment is positioned to leap into new opportunities ahead of the competition.


Genetic switch underlies C. albicans quick change act.

Vance E - PLoS Biol. (2011)

New research supports a new model to explain how C. albicans, the most common cause of invasive fungal infections in humans, manages the morphological plasticity necessary for pathogenesis.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3139635&req=5

pbio-1001108-g001: New research supports a new model to explain how C. albicans, the most common cause of invasive fungal infections in humans, manages the morphological plasticity necessary for pathogenesis.
Mentions: In the fungus world, just as in the business one, the key to success is flexibility. A fungus that can adapt and change to its environment is positioned to leap into new opportunities ahead of the competition.

View Article: PubMed Central - PubMed

Affiliation: Mexico City, Mexico.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

In the yeast form, it is not terribly dangerous but is highly mobile, hitching a ride in blood flows or other body processes... The hypha form spreads faster, given its filamentous-like nature, but cannot, for example, move into the bloodstream, and its ill-effects are limited... Sometimes the fungi will even switch as self-defense, using hyphal structures to fend off attackers... As a result, scientists have long tried to understand the mechanisms that allow C. albicans to quickly slip between hypha and yeast phase... A team at the University of California Irvine has painstakingly narrowed down the process to a series of two sequential genetic triggers that give this fungus its unique advantage... First, they found that the primary obstacle to a swift yeast-hypha switch is a protein that inhibits transcription called Nrg1... The team found that before C. albicans transitions into the hyphal stage, it expunges Nrg1 by activating a major growth signaling pathway called cAMP-PKA... After the Nrg1 was evacuated, the cell began to change its shape as well as its transcriptional program... But in order to prevent Nrg1 from returning to its position on the DNA—and keep the transition process moving without interruption—another protein, called Hda1, was recruited to maintain transcription and prevent the Nrg1 from binding to DNA... The authors demonstrate this model by creating mutant strains of C. albicans that could not produce Hda1 and thus were unable to complete the transition to the hyphal stage, despite the conditions being otherwise perfect (many things can induce a change, but the team used the most reliable—raising the temperature to 37°C and mixing in blood serum)... The team also found that for a successful transition to hyphae, the yeast required rich, nutrient-packed media and that in nutrient-poor media, the hyphae simply stayed hyphae... It also may aid in finding new treatments for diseases related to C. albicans if scientists could find a way to trap the fungus in its yeast form.

No MeSH data available.


Related in: MedlinePlus