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ESBLs: A Clear and Present Danger?

Dhillon RH, Clark J - Crit Care Res Pract (2011)

Bottom Line: Extended spectrum β-lactamases (ESBLs) are enzymes produced by a variety of Gram negative bacteria which confer an increased resistance to commonly used antibiotics.Coupled with increasing prevalence rates worldwide and an ever diminishing supply in the antibiotic armamentarium, these enzymes represent a clear and present danger to public health.This article aims to give an overview of the current situation regarding ESBLs, with a focus on the epidemiology and management of such infections.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Road, London W6 8RF, UK.

ABSTRACT
Extended spectrum β-lactamases (ESBLs) are enzymes produced by a variety of Gram negative bacteria which confer an increased resistance to commonly used antibiotics. They are a worrying global public health issue as infections caused by such enzyme-producing organisms are associated with a higher morbidity and mortality and greater fiscal burden. Coupled with increasing prevalence rates worldwide and an ever diminishing supply in the antibiotic armamentarium, these enzymes represent a clear and present danger to public health. This article aims to give an overview of the current situation regarding ESBLs, with a focus on the epidemiology and management of such infections.

No MeSH data available.


Related in: MedlinePlus

MICs that are >8 fold lower with clavulanate (left) or the presence of keyhole zones (right) imply ESBL production.
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fig3: MICs that are >8 fold lower with clavulanate (left) or the presence of keyhole zones (right) imply ESBL production.

Mentions: There are a variety of commercial tools available to do this, including double disc synergy, combination disc method, and specific ESBL E-tests [49, 50] (see Figures 2 and 3).


ESBLs: A Clear and Present Danger?

Dhillon RH, Clark J - Crit Care Res Pract (2011)

MICs that are >8 fold lower with clavulanate (left) or the presence of keyhole zones (right) imply ESBL production.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3135063&req=5

fig3: MICs that are >8 fold lower with clavulanate (left) or the presence of keyhole zones (right) imply ESBL production.
Mentions: There are a variety of commercial tools available to do this, including double disc synergy, combination disc method, and specific ESBL E-tests [49, 50] (see Figures 2 and 3).

Bottom Line: Extended spectrum β-lactamases (ESBLs) are enzymes produced by a variety of Gram negative bacteria which confer an increased resistance to commonly used antibiotics.Coupled with increasing prevalence rates worldwide and an ever diminishing supply in the antibiotic armamentarium, these enzymes represent a clear and present danger to public health.This article aims to give an overview of the current situation regarding ESBLs, with a focus on the epidemiology and management of such infections.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Road, London W6 8RF, UK.

ABSTRACT
Extended spectrum β-lactamases (ESBLs) are enzymes produced by a variety of Gram negative bacteria which confer an increased resistance to commonly used antibiotics. They are a worrying global public health issue as infections caused by such enzyme-producing organisms are associated with a higher morbidity and mortality and greater fiscal burden. Coupled with increasing prevalence rates worldwide and an ever diminishing supply in the antibiotic armamentarium, these enzymes represent a clear and present danger to public health. This article aims to give an overview of the current situation regarding ESBLs, with a focus on the epidemiology and management of such infections.

No MeSH data available.


Related in: MedlinePlus