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Massive retinal gliosis: an unusual case with immunohistochemical study.

Deshmukh SD, Ashturkar AV, Babanagare SV, Gokhale SK, Deshpande AA - Indian J Ophthalmol (2011 May-Jun)

Bottom Line: Immunohistochemically, these cells show positivity for glial fibrillary acid protein (GFAP), neuron specific enolase (NSE), and S-100 protein.We encountered a case of a 45-year-old female with loss of vision in the left eye.She had a history of trauma to that eye two years ago.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Shrimati Kashibai Navale Medical College and General Hospital, Narhe, Pune-41, India. drsanjay123in@yahoo.co.in

ABSTRACT
Massive retinal gliosis (MRG) is a rare, benign intraocular condition that results from the proliferation of well-differentiated glial cells. Immunohistochemically, these cells show positivity for glial fibrillary acid protein (GFAP), neuron specific enolase (NSE), and S-100 protein. We encountered a case of a 45-year-old female with loss of vision in the left eye. She had a history of trauma to that eye two years ago. Enucleation was carried out, because malignancy was suspected due to retinal calcification. On the basis of light microscopy and immunohistochemistry (IHC) performed on the enucleated eye, it was diagnosed as massive retinal gliosis.

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The retina is replaced by spindle-shaped glial cells arranged in interlacing bundles and whorls (H and E, ×100). Individual cells are elongated, with abundant eosinophilic fibrillary cytoplasm (Inset) (H and E, ×400)
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Figure 2: The retina is replaced by spindle-shaped glial cells arranged in interlacing bundles and whorls (H and E, ×100). Individual cells are elongated, with abundant eosinophilic fibrillary cytoplasm (Inset) (H and E, ×400)

Mentions: On gross examination the eyeball was hard, shrunken, and deformed with an opaque cornea. An optic nerve measuring 5 mm length was also identified attached to the eyeball. The cut surface showed a vitreous cavity replaced by a solid, firm, homogenous gray-white mass, measuring 3.0 × 1.8 × 1.5 cm. On light microscopy, the retina was replaced by spindle-shaped glial cells arranged in interlacing bundles and whorls [Fig. 2]. Individual cells were elongated with abundant eosinophilic fibrillary cytoplasm [Fig. 3]. Thin-walled blood vessels with a thick hyaline layer were noted. Foci of calcifications were also identified. On immunohistochemical study, the spindle shaped cells showed intense positivity for glial fibrillary acidic protein (GFAP) [Fig. 3], neuron specific enolase (NSE), and S-100. Therefore, on the basis of light microscopy and immunohistochemistry study findings, a diagnosis of MRG was offered.


Massive retinal gliosis: an unusual case with immunohistochemical study.

Deshmukh SD, Ashturkar AV, Babanagare SV, Gokhale SK, Deshpande AA - Indian J Ophthalmol (2011 May-Jun)

The retina is replaced by spindle-shaped glial cells arranged in interlacing bundles and whorls (H and E, ×100). Individual cells are elongated, with abundant eosinophilic fibrillary cytoplasm (Inset) (H and E, ×400)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3120251&req=5

Figure 2: The retina is replaced by spindle-shaped glial cells arranged in interlacing bundles and whorls (H and E, ×100). Individual cells are elongated, with abundant eosinophilic fibrillary cytoplasm (Inset) (H and E, ×400)
Mentions: On gross examination the eyeball was hard, shrunken, and deformed with an opaque cornea. An optic nerve measuring 5 mm length was also identified attached to the eyeball. The cut surface showed a vitreous cavity replaced by a solid, firm, homogenous gray-white mass, measuring 3.0 × 1.8 × 1.5 cm. On light microscopy, the retina was replaced by spindle-shaped glial cells arranged in interlacing bundles and whorls [Fig. 2]. Individual cells were elongated with abundant eosinophilic fibrillary cytoplasm [Fig. 3]. Thin-walled blood vessels with a thick hyaline layer were noted. Foci of calcifications were also identified. On immunohistochemical study, the spindle shaped cells showed intense positivity for glial fibrillary acidic protein (GFAP) [Fig. 3], neuron specific enolase (NSE), and S-100. Therefore, on the basis of light microscopy and immunohistochemistry study findings, a diagnosis of MRG was offered.

Bottom Line: Immunohistochemically, these cells show positivity for glial fibrillary acid protein (GFAP), neuron specific enolase (NSE), and S-100 protein.We encountered a case of a 45-year-old female with loss of vision in the left eye.She had a history of trauma to that eye two years ago.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Shrimati Kashibai Navale Medical College and General Hospital, Narhe, Pune-41, India. drsanjay123in@yahoo.co.in

ABSTRACT
Massive retinal gliosis (MRG) is a rare, benign intraocular condition that results from the proliferation of well-differentiated glial cells. Immunohistochemically, these cells show positivity for glial fibrillary acid protein (GFAP), neuron specific enolase (NSE), and S-100 protein. We encountered a case of a 45-year-old female with loss of vision in the left eye. She had a history of trauma to that eye two years ago. Enucleation was carried out, because malignancy was suspected due to retinal calcification. On the basis of light microscopy and immunohistochemistry (IHC) performed on the enucleated eye, it was diagnosed as massive retinal gliosis.

Show MeSH
Related in: MedlinePlus