Limits...
Frosted branch angiitis, neuroretinitis as initial ocular manifestation in Behçet disease.

Al-Mujaini A, Wali UK - Indian J Ophthalmol (2011 May-Jun)

Bottom Line: Behçet disease is an idiopathic, multisystem disorder characterized by recurrent episodes of orogenital ulceration and vasculitis of the veins and arteries of all calibers.Many theories have pointed toward an autoimmune response behind its pathogenesis, which may be triggered by exposure to an infectious agent.The disease may be idiopathic in a majority of the cases or may be associated with ocular and systemic pathology.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.

ABSTRACT
Behçet disease is an idiopathic, multisystem disorder characterized by recurrent episodes of orogenital ulceration and vasculitis of the veins and arteries of all calibers. Ocular involvement may affect the conjunctiva, sclera, uveal tract, vitreous, blood vessels, and retina. Many theories have pointed toward an autoimmune response behind its pathogenesis, which may be triggered by exposure to an infectious agent. Frosted branch angiitis is characterized by vascular inflammation, sheathing, retinal edema, and retinal hemorrhages. The disease may be idiopathic in a majority of the cases or may be associated with ocular and systemic pathology. Association between Behηet disease, Frosted branch angiitis, and neuroretinitis is not reported in literature. This uncommon combination reflects the varied systemic and ocular manifestations in Behçet disease, especially in patients who are not diagnosed and treated in time. We hereby report a case of bilateral frosted branch angiitis and neuroretinitis in a young male from Middle-east, suffering from Behçet disease.

Show MeSH

Related in: MedlinePlus

(a) Right eye (2007): Frosted branch angiitis with retinal hemorrhages. (b) Present fundus picture (2009) showing superior tractional retinal detachment and atrophic macular scar, representing sequelae of old inflammation
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3120249&req=5

Figure 1: (a) Right eye (2007): Frosted branch angiitis with retinal hemorrhages. (b) Present fundus picture (2009) showing superior tractional retinal detachment and atrophic macular scar, representing sequelae of old inflammation

Mentions: His best corrected visual acuity on presentation was 20/100 and 20/20 in right and left eyes, respectively. The fundus image of right eye, in 2007, showed features of frosted branch angiitis and retinal hemorrhages [Fig. 1a]. Present examination of the right eye [Fig. 1b] revealed superior tractional retinal detachment and atrophic macular scar in the right eye, representing sequelae of the previous inflammation. The left eye showed papillitis, macular exudates, retinal edema with hemorrhages, and characteristic diffuse retinal perivascular sheathing, involving whole segments of both arterioles and venules in the left eye, suggestive of occlusive vasculitis, typical of frosted branch angiitis [Fig. 2a]. The anterior segment was normal. Fluorescein angiography (FA) showed delayed arteriovenous filling and widespread areas of capillary nonperfusion [Fig. 2b].


Frosted branch angiitis, neuroretinitis as initial ocular manifestation in Behçet disease.

Al-Mujaini A, Wali UK - Indian J Ophthalmol (2011 May-Jun)

(a) Right eye (2007): Frosted branch angiitis with retinal hemorrhages. (b) Present fundus picture (2009) showing superior tractional retinal detachment and atrophic macular scar, representing sequelae of old inflammation
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3120249&req=5

Figure 1: (a) Right eye (2007): Frosted branch angiitis with retinal hemorrhages. (b) Present fundus picture (2009) showing superior tractional retinal detachment and atrophic macular scar, representing sequelae of old inflammation
Mentions: His best corrected visual acuity on presentation was 20/100 and 20/20 in right and left eyes, respectively. The fundus image of right eye, in 2007, showed features of frosted branch angiitis and retinal hemorrhages [Fig. 1a]. Present examination of the right eye [Fig. 1b] revealed superior tractional retinal detachment and atrophic macular scar in the right eye, representing sequelae of the previous inflammation. The left eye showed papillitis, macular exudates, retinal edema with hemorrhages, and characteristic diffuse retinal perivascular sheathing, involving whole segments of both arterioles and venules in the left eye, suggestive of occlusive vasculitis, typical of frosted branch angiitis [Fig. 2a]. The anterior segment was normal. Fluorescein angiography (FA) showed delayed arteriovenous filling and widespread areas of capillary nonperfusion [Fig. 2b].

Bottom Line: Behçet disease is an idiopathic, multisystem disorder characterized by recurrent episodes of orogenital ulceration and vasculitis of the veins and arteries of all calibers.Many theories have pointed toward an autoimmune response behind its pathogenesis, which may be triggered by exposure to an infectious agent.The disease may be idiopathic in a majority of the cases or may be associated with ocular and systemic pathology.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.

ABSTRACT
Behçet disease is an idiopathic, multisystem disorder characterized by recurrent episodes of orogenital ulceration and vasculitis of the veins and arteries of all calibers. Ocular involvement may affect the conjunctiva, sclera, uveal tract, vitreous, blood vessels, and retina. Many theories have pointed toward an autoimmune response behind its pathogenesis, which may be triggered by exposure to an infectious agent. Frosted branch angiitis is characterized by vascular inflammation, sheathing, retinal edema, and retinal hemorrhages. The disease may be idiopathic in a majority of the cases or may be associated with ocular and systemic pathology. Association between Behηet disease, Frosted branch angiitis, and neuroretinitis is not reported in literature. This uncommon combination reflects the varied systemic and ocular manifestations in Behçet disease, especially in patients who are not diagnosed and treated in time. We hereby report a case of bilateral frosted branch angiitis and neuroretinitis in a young male from Middle-east, suffering from Behçet disease.

Show MeSH
Related in: MedlinePlus