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Pupil cycle time and contrast sensitivity in type II diabetes mellitus patients: a pilot study.

Lee H, Kim Y, Park J - Indian J Ophthalmol (2011 May-Jun)

Bottom Line: We divided all patients into three groups according to PCT results.Contrast sensitivity and decrease of visual acuity by glare were also estimated and analyzed for 28 eyes of 28 non-proliferative diabetic retinopathy (NPDR) patients.Contrast sensitivity in Group [NPDR] A was significantly more than in Group [NPDR] C at all cpds (all P ≤ 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea.

ABSTRACT

Context: Pupil cycle time (PCT) has been widely used for examination of ocular diabetic autonomic neuropathy (DAN).

Aims: The primary aim of this study was to evaluate the difference of contrast sensitivity according to PCT results, and the secondary aim was to determine the factors associated with PCT difference for type II diabetes patients.

Settings and design: A clinical pilot study that included a total of 60 eyes of 60 type II diabetes patients.

Materials and methods: We divided all patients into three groups according to PCT results. Group A and Group C were composed of patients who had upper one third PCT and lower one third PCT, respectively. We analyzed difference of age, diabetes duration, hypertension duration, mean best corrected visual acuity (BCVA), mean spherical equivalent (SE), HbA1C, glomerular filtration rate (GFR), stage of diabetic retinopathy, and Cardiac Autonomic Function Score (CAFS). Contrast sensitivity and decrease of visual acuity by glare were also estimated and analyzed for 28 eyes of 28 non-proliferative diabetic retinopathy (NPDR) patients. Group [NPDR] A and Group [NPDR] C were defined as those who had lower one third PCT and upper one third PCT, respectively.

Statistical analysis: Statistical analysis was done using SPSS 17.0 software.

Results and conclusions: Each group contained 20 eyes. Significant differences between Group A and Group C were observed in duration of diabetes and CAFS (P ≤ 0.001 and P < 0.001, respectively). Contrast sensitivity in Group [NPDR] A was significantly more than in Group [NPDR] C at all cpds (all P ≤ 0.001). We found that PCT can influence contrast sensitivity or glare in diabetes patients and also confirmed a significant correlation of PCT with CAFS and duration of diabetes.

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(a) Scatter of pupil cycle time and diabetes mellitus duration. Correlation coefficient was 0.905 and P value by Spearman correlation efficient test was less than 0.001. (b) Scatter of PCT and Cardiac Autonomic Function Score. Correlation coefficient was 0.538 and P value by Spearman correlation efficient test was less than 0.001
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Figure 1: (a) Scatter of pupil cycle time and diabetes mellitus duration. Correlation coefficient was 0.905 and P value by Spearman correlation efficient test was less than 0.001. (b) Scatter of PCT and Cardiac Autonomic Function Score. Correlation coefficient was 0.538 and P value by Spearman correlation efficient test was less than 0.001

Mentions: Age, hypertension, HbA1C, and GFR between Group A and Group C showed no significant difference. Duration of diabetes and CAFS showed significant difference between Group A and Group C (P ≤ 0.001 and P <0.001, respectively; by Mann-Whitney U test) [Table 2]. Correlation coefficient between PCT and duration of DM was 0.905. Correlation coefficient was 0.538 between PCT and CAFS. Both results showed significant correlation [Fig. 1a and b]. PCT was analyzed according to the stage of diabetic retinopathy for a total of 60 eyes. PCTs for no DR, NPDR, and PDR were 911.13 ± 61.59 ms, 960.03 ± 49.30 ms, and 990.81 ± 70.13 ms, respectively (P = 0.008; by Kruskal–Wallis test) [Table 3].


Pupil cycle time and contrast sensitivity in type II diabetes mellitus patients: a pilot study.

Lee H, Kim Y, Park J - Indian J Ophthalmol (2011 May-Jun)

(a) Scatter of pupil cycle time and diabetes mellitus duration. Correlation coefficient was 0.905 and P value by Spearman correlation efficient test was less than 0.001. (b) Scatter of PCT and Cardiac Autonomic Function Score. Correlation coefficient was 0.538 and P value by Spearman correlation efficient test was less than 0.001
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3120239&req=5

Figure 1: (a) Scatter of pupil cycle time and diabetes mellitus duration. Correlation coefficient was 0.905 and P value by Spearman correlation efficient test was less than 0.001. (b) Scatter of PCT and Cardiac Autonomic Function Score. Correlation coefficient was 0.538 and P value by Spearman correlation efficient test was less than 0.001
Mentions: Age, hypertension, HbA1C, and GFR between Group A and Group C showed no significant difference. Duration of diabetes and CAFS showed significant difference between Group A and Group C (P ≤ 0.001 and P <0.001, respectively; by Mann-Whitney U test) [Table 2]. Correlation coefficient between PCT and duration of DM was 0.905. Correlation coefficient was 0.538 between PCT and CAFS. Both results showed significant correlation [Fig. 1a and b]. PCT was analyzed according to the stage of diabetic retinopathy for a total of 60 eyes. PCTs for no DR, NPDR, and PDR were 911.13 ± 61.59 ms, 960.03 ± 49.30 ms, and 990.81 ± 70.13 ms, respectively (P = 0.008; by Kruskal–Wallis test) [Table 3].

Bottom Line: We divided all patients into three groups according to PCT results.Contrast sensitivity and decrease of visual acuity by glare were also estimated and analyzed for 28 eyes of 28 non-proliferative diabetic retinopathy (NPDR) patients.Contrast sensitivity in Group [NPDR] A was significantly more than in Group [NPDR] C at all cpds (all P ≤ 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea.

ABSTRACT

Context: Pupil cycle time (PCT) has been widely used for examination of ocular diabetic autonomic neuropathy (DAN).

Aims: The primary aim of this study was to evaluate the difference of contrast sensitivity according to PCT results, and the secondary aim was to determine the factors associated with PCT difference for type II diabetes patients.

Settings and design: A clinical pilot study that included a total of 60 eyes of 60 type II diabetes patients.

Materials and methods: We divided all patients into three groups according to PCT results. Group A and Group C were composed of patients who had upper one third PCT and lower one third PCT, respectively. We analyzed difference of age, diabetes duration, hypertension duration, mean best corrected visual acuity (BCVA), mean spherical equivalent (SE), HbA1C, glomerular filtration rate (GFR), stage of diabetic retinopathy, and Cardiac Autonomic Function Score (CAFS). Contrast sensitivity and decrease of visual acuity by glare were also estimated and analyzed for 28 eyes of 28 non-proliferative diabetic retinopathy (NPDR) patients. Group [NPDR] A and Group [NPDR] C were defined as those who had lower one third PCT and upper one third PCT, respectively.

Statistical analysis: Statistical analysis was done using SPSS 17.0 software.

Results and conclusions: Each group contained 20 eyes. Significant differences between Group A and Group C were observed in duration of diabetes and CAFS (P ≤ 0.001 and P < 0.001, respectively). Contrast sensitivity in Group [NPDR] A was significantly more than in Group [NPDR] C at all cpds (all P ≤ 0.001). We found that PCT can influence contrast sensitivity or glare in diabetes patients and also confirmed a significant correlation of PCT with CAFS and duration of diabetes.

Show MeSH
Related in: MedlinePlus