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Diffusion MRI of structural brain plasticity induced by a learning and memory task.

Blumenfeld-Katzir T, Pasternak O, Dagan M, Assaf Y - PLoS ONE (2011)

Bottom Line: Here we used diffusion tensor imaging (DTI) to examine the microstructural manifestations of neuroplasticity in rats that performed a spatial navigation task.We found that DTI can be used to define the selective localization of neuroplasticity induced by different tasks and that this process is age-dependent in cingulate cortex and corpus callosum and age-independent in the dentate gyrus.We relate the observed DTI changes to the structural plasticity that occurs in astrocytes and discuss the potential of MRI for probing structural neuroplasticity and hence indirectly localizing LTP.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

ABSTRACT

Background: Activity-induced structural remodeling of dendritic spines and glial cells was recently proposed as an important factor in neuroplasticity and suggested to accompany the induction of long-term potentiation (LTP). Although T1 and diffusion MRI have been used to study structural changes resulting from long-term training, the cellular basis of the findings obtained and their relationship to neuroplasticity are poorly understood.

Methodology/principal finding: Here we used diffusion tensor imaging (DTI) to examine the microstructural manifestations of neuroplasticity in rats that performed a spatial navigation task. We found that DTI can be used to define the selective localization of neuroplasticity induced by different tasks and that this process is age-dependent in cingulate cortex and corpus callosum and age-independent in the dentate gyrus.

Conclusion/significance: We relate the observed DTI changes to the structural plasticity that occurs in astrocytes and discuss the potential of MRI for probing structural neuroplasticity and hence indirectly localizing LTP.

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Related in: MedlinePlus

Histological analysis of the corpus callosum in representative mice from group L.(a) Statistical parametric maps of interaction between scan time and group in a representative slice that includes the corpus callosum (CC). An enlargement of this region is shown on the right. (b) Immunohistochemical staining (×10 magnification) of the CC for MBP. Note the increase in MBP immuno-reactivity in the CC after completion of the water maze task. The white bar at the bottom right corner represents 100 µm. (c) Quantification of the immunoreactivity (staining intensity) in the CC. Asterisk denotes P<0.05.
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pone-0020678-g004: Histological analysis of the corpus callosum in representative mice from group L.(a) Statistical parametric maps of interaction between scan time and group in a representative slice that includes the corpus callosum (CC). An enlargement of this region is shown on the right. (b) Immunohistochemical staining (×10 magnification) of the CC for MBP. Note the increase in MBP immuno-reactivity in the CC after completion of the water maze task. The white bar at the bottom right corner represents 100 µm. (c) Quantification of the immunoreactivity (staining intensity) in the CC. Asterisk denotes P<0.05.

Mentions: The CC comparison is depicted in Figure 4. Here the only cellular marker showing significant changes in immune reactivity was MBP. This result indicates that the oligodendrocytes forming the myelin sheaths produced more MBP, probably to support the required flow of information. This is in line with the increase in FA in this region, possibly implying an increase in the cellular organization and packing of axons or myelin.


Diffusion MRI of structural brain plasticity induced by a learning and memory task.

Blumenfeld-Katzir T, Pasternak O, Dagan M, Assaf Y - PLoS ONE (2011)

Histological analysis of the corpus callosum in representative mice from group L.(a) Statistical parametric maps of interaction between scan time and group in a representative slice that includes the corpus callosum (CC). An enlargement of this region is shown on the right. (b) Immunohistochemical staining (×10 magnification) of the CC for MBP. Note the increase in MBP immuno-reactivity in the CC after completion of the water maze task. The white bar at the bottom right corner represents 100 µm. (c) Quantification of the immunoreactivity (staining intensity) in the CC. Asterisk denotes P<0.05.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3119075&req=5

pone-0020678-g004: Histological analysis of the corpus callosum in representative mice from group L.(a) Statistical parametric maps of interaction between scan time and group in a representative slice that includes the corpus callosum (CC). An enlargement of this region is shown on the right. (b) Immunohistochemical staining (×10 magnification) of the CC for MBP. Note the increase in MBP immuno-reactivity in the CC after completion of the water maze task. The white bar at the bottom right corner represents 100 µm. (c) Quantification of the immunoreactivity (staining intensity) in the CC. Asterisk denotes P<0.05.
Mentions: The CC comparison is depicted in Figure 4. Here the only cellular marker showing significant changes in immune reactivity was MBP. This result indicates that the oligodendrocytes forming the myelin sheaths produced more MBP, probably to support the required flow of information. This is in line with the increase in FA in this region, possibly implying an increase in the cellular organization and packing of axons or myelin.

Bottom Line: Here we used diffusion tensor imaging (DTI) to examine the microstructural manifestations of neuroplasticity in rats that performed a spatial navigation task.We found that DTI can be used to define the selective localization of neuroplasticity induced by different tasks and that this process is age-dependent in cingulate cortex and corpus callosum and age-independent in the dentate gyrus.We relate the observed DTI changes to the structural plasticity that occurs in astrocytes and discuss the potential of MRI for probing structural neuroplasticity and hence indirectly localizing LTP.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

ABSTRACT

Background: Activity-induced structural remodeling of dendritic spines and glial cells was recently proposed as an important factor in neuroplasticity and suggested to accompany the induction of long-term potentiation (LTP). Although T1 and diffusion MRI have been used to study structural changes resulting from long-term training, the cellular basis of the findings obtained and their relationship to neuroplasticity are poorly understood.

Methodology/principal finding: Here we used diffusion tensor imaging (DTI) to examine the microstructural manifestations of neuroplasticity in rats that performed a spatial navigation task. We found that DTI can be used to define the selective localization of neuroplasticity induced by different tasks and that this process is age-dependent in cingulate cortex and corpus callosum and age-independent in the dentate gyrus.

Conclusion/significance: We relate the observed DTI changes to the structural plasticity that occurs in astrocytes and discuss the potential of MRI for probing structural neuroplasticity and hence indirectly localizing LTP.

Show MeSH
Related in: MedlinePlus