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Diffusion MRI of structural brain plasticity induced by a learning and memory task.

Blumenfeld-Katzir T, Pasternak O, Dagan M, Assaf Y - PLoS ONE (2011)

Bottom Line: Here we used diffusion tensor imaging (DTI) to examine the microstructural manifestations of neuroplasticity in rats that performed a spatial navigation task.We found that DTI can be used to define the selective localization of neuroplasticity induced by different tasks and that this process is age-dependent in cingulate cortex and corpus callosum and age-independent in the dentate gyrus.We relate the observed DTI changes to the structural plasticity that occurs in astrocytes and discuss the potential of MRI for probing structural neuroplasticity and hence indirectly localizing LTP.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

ABSTRACT

Background: Activity-induced structural remodeling of dendritic spines and glial cells was recently proposed as an important factor in neuroplasticity and suggested to accompany the induction of long-term potentiation (LTP). Although T1 and diffusion MRI have been used to study structural changes resulting from long-term training, the cellular basis of the findings obtained and their relationship to neuroplasticity are poorly understood.

Methodology/principal finding: Here we used diffusion tensor imaging (DTI) to examine the microstructural manifestations of neuroplasticity in rats that performed a spatial navigation task. We found that DTI can be used to define the selective localization of neuroplasticity induced by different tasks and that this process is age-dependent in cingulate cortex and corpus callosum and age-independent in the dentate gyrus.

Conclusion/significance: We relate the observed DTI changes to the structural plasticity that occurs in astrocytes and discuss the potential of MRI for probing structural neuroplasticity and hence indirectly localizing LTP.

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Regional analysis of the parametric interaction maps.Type 1 of interaction, i.e., regions that exhibit significant changes in the learning group (L) only were identified in ADC in the dentate gyrus (a) and piriform cortex (b) and FA in the cingulate cortex (c) and corpus callosum (d). Type 2 of interaction, i.e., regions that exhibit significant changes in the swimming-only (S) group and to lesser extent in the learning (L) group was found in the S1/S2 cortex (e). (f) Brain atlas diagram with the abovementioned regions indicated.
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pone-0020678-g002: Regional analysis of the parametric interaction maps.Type 1 of interaction, i.e., regions that exhibit significant changes in the learning group (L) only were identified in ADC in the dentate gyrus (a) and piriform cortex (b) and FA in the cingulate cortex (c) and corpus callosum (d). Type 2 of interaction, i.e., regions that exhibit significant changes in the swimming-only (S) group and to lesser extent in the learning (L) group was found in the S1/S2 cortex (e). (f) Brain atlas diagram with the abovementioned regions indicated.

Mentions: Regional analysis of each of the ANOVA interaction clusters was used to identify the study groups contributing to the interaction. The analysis yielded two types of interactions. In the first, group L contributed to the interaction with no apparent changes in groups S and NL. In the second, group S contributed to the interaction with no apparent changes in groups L or NL. Figure 2 presents the regional analysis for the two types of interaction. The first included a decrease in ADC (2%–3%) in the DG (Fig. 2a) and PC (Fig. 2b); a decrease in FA (2%–3%) in the CG (Fig. 2c), and an increase in FA (2%–4%) in the CC (Fig. 2d). The second included a decrease in ADC (∼6%) in the SC (Fig. 2e).


Diffusion MRI of structural brain plasticity induced by a learning and memory task.

Blumenfeld-Katzir T, Pasternak O, Dagan M, Assaf Y - PLoS ONE (2011)

Regional analysis of the parametric interaction maps.Type 1 of interaction, i.e., regions that exhibit significant changes in the learning group (L) only were identified in ADC in the dentate gyrus (a) and piriform cortex (b) and FA in the cingulate cortex (c) and corpus callosum (d). Type 2 of interaction, i.e., regions that exhibit significant changes in the swimming-only (S) group and to lesser extent in the learning (L) group was found in the S1/S2 cortex (e). (f) Brain atlas diagram with the abovementioned regions indicated.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3119075&req=5

pone-0020678-g002: Regional analysis of the parametric interaction maps.Type 1 of interaction, i.e., regions that exhibit significant changes in the learning group (L) only were identified in ADC in the dentate gyrus (a) and piriform cortex (b) and FA in the cingulate cortex (c) and corpus callosum (d). Type 2 of interaction, i.e., regions that exhibit significant changes in the swimming-only (S) group and to lesser extent in the learning (L) group was found in the S1/S2 cortex (e). (f) Brain atlas diagram with the abovementioned regions indicated.
Mentions: Regional analysis of each of the ANOVA interaction clusters was used to identify the study groups contributing to the interaction. The analysis yielded two types of interactions. In the first, group L contributed to the interaction with no apparent changes in groups S and NL. In the second, group S contributed to the interaction with no apparent changes in groups L or NL. Figure 2 presents the regional analysis for the two types of interaction. The first included a decrease in ADC (2%–3%) in the DG (Fig. 2a) and PC (Fig. 2b); a decrease in FA (2%–3%) in the CG (Fig. 2c), and an increase in FA (2%–4%) in the CC (Fig. 2d). The second included a decrease in ADC (∼6%) in the SC (Fig. 2e).

Bottom Line: Here we used diffusion tensor imaging (DTI) to examine the microstructural manifestations of neuroplasticity in rats that performed a spatial navigation task.We found that DTI can be used to define the selective localization of neuroplasticity induced by different tasks and that this process is age-dependent in cingulate cortex and corpus callosum and age-independent in the dentate gyrus.We relate the observed DTI changes to the structural plasticity that occurs in astrocytes and discuss the potential of MRI for probing structural neuroplasticity and hence indirectly localizing LTP.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

ABSTRACT

Background: Activity-induced structural remodeling of dendritic spines and glial cells was recently proposed as an important factor in neuroplasticity and suggested to accompany the induction of long-term potentiation (LTP). Although T1 and diffusion MRI have been used to study structural changes resulting from long-term training, the cellular basis of the findings obtained and their relationship to neuroplasticity are poorly understood.

Methodology/principal finding: Here we used diffusion tensor imaging (DTI) to examine the microstructural manifestations of neuroplasticity in rats that performed a spatial navigation task. We found that DTI can be used to define the selective localization of neuroplasticity induced by different tasks and that this process is age-dependent in cingulate cortex and corpus callosum and age-independent in the dentate gyrus.

Conclusion/significance: We relate the observed DTI changes to the structural plasticity that occurs in astrocytes and discuss the potential of MRI for probing structural neuroplasticity and hence indirectly localizing LTP.

Show MeSH