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Factors influencing cancer risk perception in high risk populations: a systematic review.

Tilburt JC, James KM, Sinicrope PS, Eton DT, Costello BA, Carey J, Lane MA, Ehlers SL, Erwin PJ, Nowakowski KE, Murad MH - Hered Cancer Clin Pract (2011)

Bottom Line: However, little is known about clinical, demographic, or psychosocial predictors that may impact risk perception in these groups.Of 1028 titles identified, 53 articles met our criteria.Future rigorous risk perception research using experimental designs and focused on cancers other than breast would advance the field.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. tilburt.jon@mayo.edu.

ABSTRACT

Background: Patients at higher than average risk of heritable cancer may process risk information differently than the general population. However, little is known about clinical, demographic, or psychosocial predictors that may impact risk perception in these groups. The objective of this study was to characterize factors associated with perceived risk of developing cancer in groups at high risk for cancer based on genetics or family history.

Methods: We searched Ovid MEDLINE, Ovid Embase, Ovid PsycInfo, and Scopus from inception through April 2009 for English-language, original investigations in humans using core concepts of "risk" and "cancer." We abstracted key information and then further restricted articles dealing with perceived risk of developing cancer due to inherited risk.

Results: Of 1028 titles identified, 53 articles met our criteria. Most (92%) used an observational design and focused on women (70%) with a family history of or contemplating genetic testing for breast cancer. Of the 53 studies, 36 focused on patients who had not had genetic testing for cancer risk, 17 included studies of patients who had undergone genetic testing for cancer risk. Family history of cancer, previous prophylactic tests and treatments, and younger age were associated with cancer risk perception. In addition, beliefs about the preventability and severity of cancer, personality factors such as "monitoring" personality, the ability to process numerical information, as well as distress/worry also were associated with cancer risk perception. Few studies addressed non-breast cancer or risk perception in specific demographic groups (e.g. elderly or minority groups) and few employed theory-driven analytic strategies to decipher interrelationships of factors.

Conclusions: Several factors influence cancer risk perception in patients at elevated risk for cancer. The science of characterizing and improving risk perception in cancer for high risk groups, although evolving, is still relatively undeveloped in several key topic areas including cancers other than breast and in specific populations. Future rigorous risk perception research using experimental designs and focused on cancers other than breast would advance the field.

No MeSH data available.


Related in: MedlinePlus

Interrelated factors associated with cancer risk perception. Conceptual model of factors thought to be associated with perceived risk for cancer.
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Figure 1: Interrelated factors associated with cancer risk perception. Conceptual model of factors thought to be associated with perceived risk for cancer.

Mentions: Considering the heterogeneity of the included studies in terms of design, population, type of cancer and outcome measures, and because the review was designed to generate (not test) hypotheses for future research, we did not conduct a meta-analysis. Data were tabulated and categorized according to the factors that affected risk perception. Narrative synopses describing the tested associations and the main findings of each study are presented (Tables 2 &3). These summaries provided the empirical basis upon which to build a conceptual model of factors influencing risk perception in cancer (Figure 1). Since the included studies were mostly of a cross-sectional design, the quality of evidence was considered to be low and at high risk of bias. Therefore we did not extract data about bias protection measures in the included studies.


Factors influencing cancer risk perception in high risk populations: a systematic review.

Tilburt JC, James KM, Sinicrope PS, Eton DT, Costello BA, Carey J, Lane MA, Ehlers SL, Erwin PJ, Nowakowski KE, Murad MH - Hered Cancer Clin Pract (2011)

Interrelated factors associated with cancer risk perception. Conceptual model of factors thought to be associated with perceived risk for cancer.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3118965&req=5

Figure 1: Interrelated factors associated with cancer risk perception. Conceptual model of factors thought to be associated with perceived risk for cancer.
Mentions: Considering the heterogeneity of the included studies in terms of design, population, type of cancer and outcome measures, and because the review was designed to generate (not test) hypotheses for future research, we did not conduct a meta-analysis. Data were tabulated and categorized according to the factors that affected risk perception. Narrative synopses describing the tested associations and the main findings of each study are presented (Tables 2 &3). These summaries provided the empirical basis upon which to build a conceptual model of factors influencing risk perception in cancer (Figure 1). Since the included studies were mostly of a cross-sectional design, the quality of evidence was considered to be low and at high risk of bias. Therefore we did not extract data about bias protection measures in the included studies.

Bottom Line: However, little is known about clinical, demographic, or psychosocial predictors that may impact risk perception in these groups.Of 1028 titles identified, 53 articles met our criteria.Future rigorous risk perception research using experimental designs and focused on cancers other than breast would advance the field.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. tilburt.jon@mayo.edu.

ABSTRACT

Background: Patients at higher than average risk of heritable cancer may process risk information differently than the general population. However, little is known about clinical, demographic, or psychosocial predictors that may impact risk perception in these groups. The objective of this study was to characterize factors associated with perceived risk of developing cancer in groups at high risk for cancer based on genetics or family history.

Methods: We searched Ovid MEDLINE, Ovid Embase, Ovid PsycInfo, and Scopus from inception through April 2009 for English-language, original investigations in humans using core concepts of "risk" and "cancer." We abstracted key information and then further restricted articles dealing with perceived risk of developing cancer due to inherited risk.

Results: Of 1028 titles identified, 53 articles met our criteria. Most (92%) used an observational design and focused on women (70%) with a family history of or contemplating genetic testing for breast cancer. Of the 53 studies, 36 focused on patients who had not had genetic testing for cancer risk, 17 included studies of patients who had undergone genetic testing for cancer risk. Family history of cancer, previous prophylactic tests and treatments, and younger age were associated with cancer risk perception. In addition, beliefs about the preventability and severity of cancer, personality factors such as "monitoring" personality, the ability to process numerical information, as well as distress/worry also were associated with cancer risk perception. Few studies addressed non-breast cancer or risk perception in specific demographic groups (e.g. elderly or minority groups) and few employed theory-driven analytic strategies to decipher interrelationships of factors.

Conclusions: Several factors influence cancer risk perception in patients at elevated risk for cancer. The science of characterizing and improving risk perception in cancer for high risk groups, although evolving, is still relatively undeveloped in several key topic areas including cancers other than breast and in specific populations. Future rigorous risk perception research using experimental designs and focused on cancers other than breast would advance the field.

No MeSH data available.


Related in: MedlinePlus