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Evaluation of tumor necrosis factor-α (TNF-α) levels in plasma and their correlation with periodontal status in obese and non-obese subjects.

Khanna S, Mali AM - J Indian Soc Periodontol (2010)

Bottom Line: The BMI, TNF-α levels in plasma and Periodontal Disease Index (PDI) scores were assessed, compared and correlated.Significantly higher PDI scores and TNF-α levels were found in the obese group as compared to those in the non-obese group.Also, a significant and positive correlation was seen between BMI and TNF-α, TNF-α and PDI as well as BMI and PDI.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology, Bharati Vidyapeeth Dental College and Hospital, Pune, India.

ABSTRACT

Background: Obesity is emerging as a significant health problem worldwide and is a risk factor for various systemic diseases. Periodontal disease is a multifactorial inflammatory disease. Recent evidence points to a link between obesity and periodontal disease, and a role for tumor necrosis factor-α (TNF-α) has been suggested.

Materials and method: FORTY NONDIABETIC SUBJECTS WERE DIVIDED INTO TWO GROUPS: group A (non-obese) included subjects with body mass index (BMI) of 18.5 to 27 kg/m2, and group B (obese) included subjects with BMI>27 kg/m2. The BMI, TNF-α levels in plasma and Periodontal Disease Index (PDI) scores were assessed, compared and correlated.

Results: Significantly higher PDI scores and TNF-α levels were found in the obese group as compared to those in the non-obese group. Also, a significant and positive correlation was seen between BMI and TNF-α, TNF-α and PDI as well as BMI and PDI.

Conclusion: Increase in the levels of tumor necrosis factor-a in plasma and an increase in the severity of periodontal disease may be seen in subjects with a higher body mass index (BMI). This indicates that obesity may be detrimental to the periodontal health of individuals.

No MeSH data available.


Related in: MedlinePlus

Correlation between BMI and PDI among the subjects of the non-obese group
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Figure 8: Correlation between BMI and PDI among the subjects of the non-obese group

Mentions: Analysis of the relationship between BMI and PDI scores revealed that when allthe subjects (obese and non-obese) were considered together, the Pearson's correlation coefficient was 0.887 (P=.000). When only the obese group was considered, the Pearson's correlation coefficient was 0.632 (P=.003); and when only the non-obese group was considered, the Pearson's correlation coefficient was 0.322 (P=.166). Coefficients of correlation between BMI and PDI scores were statistically highly significant and also high, consistent and positive when all subjects were considered together and also when only obese group was considered. This may suggest that PDI score increases with the increase in BMI in obese individuals. However, when only non-obese group was considered, a weak positive correlation was seen, but it was not statistically significant [Figures 7 and 8].


Evaluation of tumor necrosis factor-α (TNF-α) levels in plasma and their correlation with periodontal status in obese and non-obese subjects.

Khanna S, Mali AM - J Indian Soc Periodontol (2010)

Correlation between BMI and PDI among the subjects of the non-obese group
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3118070&req=5

Figure 8: Correlation between BMI and PDI among the subjects of the non-obese group
Mentions: Analysis of the relationship between BMI and PDI scores revealed that when allthe subjects (obese and non-obese) were considered together, the Pearson's correlation coefficient was 0.887 (P=.000). When only the obese group was considered, the Pearson's correlation coefficient was 0.632 (P=.003); and when only the non-obese group was considered, the Pearson's correlation coefficient was 0.322 (P=.166). Coefficients of correlation between BMI and PDI scores were statistically highly significant and also high, consistent and positive when all subjects were considered together and also when only obese group was considered. This may suggest that PDI score increases with the increase in BMI in obese individuals. However, when only non-obese group was considered, a weak positive correlation was seen, but it was not statistically significant [Figures 7 and 8].

Bottom Line: The BMI, TNF-α levels in plasma and Periodontal Disease Index (PDI) scores were assessed, compared and correlated.Significantly higher PDI scores and TNF-α levels were found in the obese group as compared to those in the non-obese group.Also, a significant and positive correlation was seen between BMI and TNF-α, TNF-α and PDI as well as BMI and PDI.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology, Bharati Vidyapeeth Dental College and Hospital, Pune, India.

ABSTRACT

Background: Obesity is emerging as a significant health problem worldwide and is a risk factor for various systemic diseases. Periodontal disease is a multifactorial inflammatory disease. Recent evidence points to a link between obesity and periodontal disease, and a role for tumor necrosis factor-α (TNF-α) has been suggested.

Materials and method: FORTY NONDIABETIC SUBJECTS WERE DIVIDED INTO TWO GROUPS: group A (non-obese) included subjects with body mass index (BMI) of 18.5 to 27 kg/m2, and group B (obese) included subjects with BMI>27 kg/m2. The BMI, TNF-α levels in plasma and Periodontal Disease Index (PDI) scores were assessed, compared and correlated.

Results: Significantly higher PDI scores and TNF-α levels were found in the obese group as compared to those in the non-obese group. Also, a significant and positive correlation was seen between BMI and TNF-α, TNF-α and PDI as well as BMI and PDI.

Conclusion: Increase in the levels of tumor necrosis factor-a in plasma and an increase in the severity of periodontal disease may be seen in subjects with a higher body mass index (BMI). This indicates that obesity may be detrimental to the periodontal health of individuals.

No MeSH data available.


Related in: MedlinePlus