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Evaluation of tumor necrosis factor-α (TNF-α) levels in plasma and their correlation with periodontal status in obese and non-obese subjects.

Khanna S, Mali AM - J Indian Soc Periodontol (2010)

Bottom Line: The BMI, TNF-α levels in plasma and Periodontal Disease Index (PDI) scores were assessed, compared and correlated.Significantly higher PDI scores and TNF-α levels were found in the obese group as compared to those in the non-obese group.Also, a significant and positive correlation was seen between BMI and TNF-α, TNF-α and PDI as well as BMI and PDI.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology, Bharati Vidyapeeth Dental College and Hospital, Pune, India.

ABSTRACT

Background: Obesity is emerging as a significant health problem worldwide and is a risk factor for various systemic diseases. Periodontal disease is a multifactorial inflammatory disease. Recent evidence points to a link between obesity and periodontal disease, and a role for tumor necrosis factor-α (TNF-α) has been suggested.

Materials and method: FORTY NONDIABETIC SUBJECTS WERE DIVIDED INTO TWO GROUPS: group A (non-obese) included subjects with body mass index (BMI) of 18.5 to 27 kg/m2, and group B (obese) included subjects with BMI>27 kg/m2. The BMI, TNF-α levels in plasma and Periodontal Disease Index (PDI) scores were assessed, compared and correlated.

Results: Significantly higher PDI scores and TNF-α levels were found in the obese group as compared to those in the non-obese group. Also, a significant and positive correlation was seen between BMI and TNF-α, TNF-α and PDI as well as BMI and PDI.

Conclusion: Increase in the levels of tumor necrosis factor-a in plasma and an increase in the severity of periodontal disease may be seen in subjects with a higher body mass index (BMI). This indicates that obesity may be detrimental to the periodontal health of individuals.

No MeSH data available.


Related in: MedlinePlus

Correlation between TNF-α and PDI among the subjects of the obese group
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Figure 5: Correlation between TNF-α and PDI among the subjects of the obese group

Mentions: The TNF-α levels in plasma were also correlated with the PDI scores. When allthe subjects (obese and non-obese) were considered together, the Pearson's correlation coefficient was 0.733 (P=.000). When only the obese group was considered, the Pearson's correlation coefficient was 0.609 (P=.004); and when only the non-obese group was considered, the Pearson's correlation coefficient was (P=.019). Coefficients of correlation between TNF-α levels and PDI scores were statistically highly significant and also high, consistent and positive [Figures 5 and 6].


Evaluation of tumor necrosis factor-α (TNF-α) levels in plasma and their correlation with periodontal status in obese and non-obese subjects.

Khanna S, Mali AM - J Indian Soc Periodontol (2010)

Correlation between TNF-α and PDI among the subjects of the obese group
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3118070&req=5

Figure 5: Correlation between TNF-α and PDI among the subjects of the obese group
Mentions: The TNF-α levels in plasma were also correlated with the PDI scores. When allthe subjects (obese and non-obese) were considered together, the Pearson's correlation coefficient was 0.733 (P=.000). When only the obese group was considered, the Pearson's correlation coefficient was 0.609 (P=.004); and when only the non-obese group was considered, the Pearson's correlation coefficient was (P=.019). Coefficients of correlation between TNF-α levels and PDI scores were statistically highly significant and also high, consistent and positive [Figures 5 and 6].

Bottom Line: The BMI, TNF-α levels in plasma and Periodontal Disease Index (PDI) scores were assessed, compared and correlated.Significantly higher PDI scores and TNF-α levels were found in the obese group as compared to those in the non-obese group.Also, a significant and positive correlation was seen between BMI and TNF-α, TNF-α and PDI as well as BMI and PDI.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology, Bharati Vidyapeeth Dental College and Hospital, Pune, India.

ABSTRACT

Background: Obesity is emerging as a significant health problem worldwide and is a risk factor for various systemic diseases. Periodontal disease is a multifactorial inflammatory disease. Recent evidence points to a link between obesity and periodontal disease, and a role for tumor necrosis factor-α (TNF-α) has been suggested.

Materials and method: FORTY NONDIABETIC SUBJECTS WERE DIVIDED INTO TWO GROUPS: group A (non-obese) included subjects with body mass index (BMI) of 18.5 to 27 kg/m2, and group B (obese) included subjects with BMI>27 kg/m2. The BMI, TNF-α levels in plasma and Periodontal Disease Index (PDI) scores were assessed, compared and correlated.

Results: Significantly higher PDI scores and TNF-α levels were found in the obese group as compared to those in the non-obese group. Also, a significant and positive correlation was seen between BMI and TNF-α, TNF-α and PDI as well as BMI and PDI.

Conclusion: Increase in the levels of tumor necrosis factor-a in plasma and an increase in the severity of periodontal disease may be seen in subjects with a higher body mass index (BMI). This indicates that obesity may be detrimental to the periodontal health of individuals.

No MeSH data available.


Related in: MedlinePlus