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Evaluation of tumor necrosis factor-α (TNF-α) levels in plasma and their correlation with periodontal status in obese and non-obese subjects.

Khanna S, Mali AM - J Indian Soc Periodontol (2010)

Bottom Line: The BMI, TNF-α levels in plasma and Periodontal Disease Index (PDI) scores were assessed, compared and correlated.Significantly higher PDI scores and TNF-α levels were found in the obese group as compared to those in the non-obese group.Also, a significant and positive correlation was seen between BMI and TNF-α, TNF-α and PDI as well as BMI and PDI.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology, Bharati Vidyapeeth Dental College and Hospital, Pune, India.

ABSTRACT

Background: Obesity is emerging as a significant health problem worldwide and is a risk factor for various systemic diseases. Periodontal disease is a multifactorial inflammatory disease. Recent evidence points to a link between obesity and periodontal disease, and a role for tumor necrosis factor-α (TNF-α) has been suggested.

Materials and method: FORTY NONDIABETIC SUBJECTS WERE DIVIDED INTO TWO GROUPS: group A (non-obese) included subjects with body mass index (BMI) of 18.5 to 27 kg/m2, and group B (obese) included subjects with BMI>27 kg/m2. The BMI, TNF-α levels in plasma and Periodontal Disease Index (PDI) scores were assessed, compared and correlated.

Results: Significantly higher PDI scores and TNF-α levels were found in the obese group as compared to those in the non-obese group. Also, a significant and positive correlation was seen between BMI and TNF-α, TNF-α and PDI as well as BMI and PDI.

Conclusion: Increase in the levels of tumor necrosis factor-a in plasma and an increase in the severity of periodontal disease may be seen in subjects with a higher body mass index (BMI). This indicates that obesity may be detrimental to the periodontal health of individuals.

No MeSH data available.


Related in: MedlinePlus

Comparison between mean TNF-α levels
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Figure 1: Comparison between mean TNF-α levels

Mentions: The mean body mass index (BMI) in the obese group was 35.20±5.10 kg/m2 , while the mean BMI in the non-obese group was 22.91±1.74 kg/m2 . The estimated levels of tumor necrosis factor-α (TNF-α) in plasma of obese subjects was 4.94±0.56 pg/mL, and the estimated levels of (TNF-α) in plasma of non-obese subjects was 4.27±0.41 pg/ml [Figure 1]. A statistically significant difference between the two groups was observed using the t test, with higher BMI and higher (TNF-α) levels in the obese group (P=.000) [Figure 1].


Evaluation of tumor necrosis factor-α (TNF-α) levels in plasma and their correlation with periodontal status in obese and non-obese subjects.

Khanna S, Mali AM - J Indian Soc Periodontol (2010)

Comparison between mean TNF-α levels
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3118070&req=5

Figure 1: Comparison between mean TNF-α levels
Mentions: The mean body mass index (BMI) in the obese group was 35.20±5.10 kg/m2 , while the mean BMI in the non-obese group was 22.91±1.74 kg/m2 . The estimated levels of tumor necrosis factor-α (TNF-α) in plasma of obese subjects was 4.94±0.56 pg/mL, and the estimated levels of (TNF-α) in plasma of non-obese subjects was 4.27±0.41 pg/ml [Figure 1]. A statistically significant difference between the two groups was observed using the t test, with higher BMI and higher (TNF-α) levels in the obese group (P=.000) [Figure 1].

Bottom Line: The BMI, TNF-α levels in plasma and Periodontal Disease Index (PDI) scores were assessed, compared and correlated.Significantly higher PDI scores and TNF-α levels were found in the obese group as compared to those in the non-obese group.Also, a significant and positive correlation was seen between BMI and TNF-α, TNF-α and PDI as well as BMI and PDI.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology, Bharati Vidyapeeth Dental College and Hospital, Pune, India.

ABSTRACT

Background: Obesity is emerging as a significant health problem worldwide and is a risk factor for various systemic diseases. Periodontal disease is a multifactorial inflammatory disease. Recent evidence points to a link between obesity and periodontal disease, and a role for tumor necrosis factor-α (TNF-α) has been suggested.

Materials and method: FORTY NONDIABETIC SUBJECTS WERE DIVIDED INTO TWO GROUPS: group A (non-obese) included subjects with body mass index (BMI) of 18.5 to 27 kg/m2, and group B (obese) included subjects with BMI>27 kg/m2. The BMI, TNF-α levels in plasma and Periodontal Disease Index (PDI) scores were assessed, compared and correlated.

Results: Significantly higher PDI scores and TNF-α levels were found in the obese group as compared to those in the non-obese group. Also, a significant and positive correlation was seen between BMI and TNF-α, TNF-α and PDI as well as BMI and PDI.

Conclusion: Increase in the levels of tumor necrosis factor-a in plasma and an increase in the severity of periodontal disease may be seen in subjects with a higher body mass index (BMI). This indicates that obesity may be detrimental to the periodontal health of individuals.

No MeSH data available.


Related in: MedlinePlus