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Uncommon manifestations of Endocervical Malignant Mixed Mullerian Tumor with Incidental Bilateral Fallopian Tube Carcinoma.

Prasad KH, Makannavar JH, Shetty J - J Lab Physicians (2011)

Bottom Line: Histopathology revealed malignant mixed Mullerian tumor.The patient was treated with carboplatin regime and found to be disease-free for 1 year.This case presented because of a rare combination of the lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, K S Hegde Medical Academy of Nitte University, Mangalore, Karnataka, India.

ABSTRACT
A 43-year-old perimenopausal lady presented with bleeding per vagina and lower abdominal pain. On evaluation, she had cervical polyp, which expelled spontaneously during the per speculum examination. Histopathology revealed malignant mixed Mullerian tumor. Extended hysterectomy with salphingo oophorectomy was carried out, which showed bilateral fallopian tube carcinoma and leiomyoma uterus. The patient was treated with carboplatin regime and found to be disease-free for 1 year. This case presented because of a rare combination of the lesions.

No MeSH data available.


Related in: MedlinePlus

(a) Left fallopian tube carcinoma with in situ carcinoma (hematoxylin and eosin, ×100) (b) Right fallopian tube carcinoma with invasive carcinoma (hematoxylin and eosin, ×400)
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Figure 3: (a) Left fallopian tube carcinoma with in situ carcinoma (hematoxylin and eosin, ×100) (b) Right fallopian tube carcinoma with invasive carcinoma (hematoxylin and eosin, ×400)

Mentions: The extended hysterectomy specimen showed tiny friable material in the endocervical region [Figure 2b] and intramural leiomyoma, 1cm × 0.5cm in the posterior wall of the uterus. The left fallopian tube was tortuous and dilated, 4cm × 2cm × 1cm. The right fallopian tube was enlarged and tortuous, 5cm × 2cm × 2cm, with a solid grey white to yellowish appearance on the cut surface. Microscopy showed a proliferative endometrium. The endocervix showed minute papillary carcinomatous tissue tethered to the surface. The myometrium showed tiny intramural leiomyoma. The left fallopian tube showed in situ papillary carcinoma [Figure 3a].The right fallopian tube showed invasive serous papillary carcinoma with in situ changes in the adjoining tubal epithelium [Figure 3b]. Both ovaries were normal. In view of the histological findings in the expelled polyp, curettage material and with the hysterectomy findings, a final diagnosis of MMMT-endocervix, intramural leiomyoma and bilateral primary fallopian tube carcinoma was made.


Uncommon manifestations of Endocervical Malignant Mixed Mullerian Tumor with Incidental Bilateral Fallopian Tube Carcinoma.

Prasad KH, Makannavar JH, Shetty J - J Lab Physicians (2011)

(a) Left fallopian tube carcinoma with in situ carcinoma (hematoxylin and eosin, ×100) (b) Right fallopian tube carcinoma with invasive carcinoma (hematoxylin and eosin, ×400)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3118060&req=5

Figure 3: (a) Left fallopian tube carcinoma with in situ carcinoma (hematoxylin and eosin, ×100) (b) Right fallopian tube carcinoma with invasive carcinoma (hematoxylin and eosin, ×400)
Mentions: The extended hysterectomy specimen showed tiny friable material in the endocervical region [Figure 2b] and intramural leiomyoma, 1cm × 0.5cm in the posterior wall of the uterus. The left fallopian tube was tortuous and dilated, 4cm × 2cm × 1cm. The right fallopian tube was enlarged and tortuous, 5cm × 2cm × 2cm, with a solid grey white to yellowish appearance on the cut surface. Microscopy showed a proliferative endometrium. The endocervix showed minute papillary carcinomatous tissue tethered to the surface. The myometrium showed tiny intramural leiomyoma. The left fallopian tube showed in situ papillary carcinoma [Figure 3a].The right fallopian tube showed invasive serous papillary carcinoma with in situ changes in the adjoining tubal epithelium [Figure 3b]. Both ovaries were normal. In view of the histological findings in the expelled polyp, curettage material and with the hysterectomy findings, a final diagnosis of MMMT-endocervix, intramural leiomyoma and bilateral primary fallopian tube carcinoma was made.

Bottom Line: Histopathology revealed malignant mixed Mullerian tumor.The patient was treated with carboplatin regime and found to be disease-free for 1 year.This case presented because of a rare combination of the lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, K S Hegde Medical Academy of Nitte University, Mangalore, Karnataka, India.

ABSTRACT
A 43-year-old perimenopausal lady presented with bleeding per vagina and lower abdominal pain. On evaluation, she had cervical polyp, which expelled spontaneously during the per speculum examination. Histopathology revealed malignant mixed Mullerian tumor. Extended hysterectomy with salphingo oophorectomy was carried out, which showed bilateral fallopian tube carcinoma and leiomyoma uterus. The patient was treated with carboplatin regime and found to be disease-free for 1 year. This case presented because of a rare combination of the lesions.

No MeSH data available.


Related in: MedlinePlus