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Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise.

Penna F, Busquets S, Pin F, Toledo M, Baccino FM, López-Soriano FJ, Costelli P, Argilés JM - J Cachexia Sarcopenia Muscle (2011)

Bottom Line: BACKGROUND: Cancer cachexia is a syndrome characterized by loss of skeletal muscle protein, depletion of lipid stores, anorexia, weakness, and perturbations of the hormonal homeostasis.RESULTS: EPA alone did not prevent the muscle loss induced by tumor growth while the combination with exercise induced a partial rescue of muscle strength and mass.ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13539-011-0028-4) contains supplementary material, which is available to authorized users.

View Article: PubMed Central - PubMed

ABSTRACT
BACKGROUND: Cancer cachexia is a syndrome characterized by loss of skeletal muscle protein, depletion of lipid stores, anorexia, weakness, and perturbations of the hormonal homeostasis. Despite several therapeutic approaches described in the past, effective interventions countering cancer cachexia are still lacking. METHODS: The present work was aimed to verify the ability of eicosapentaenoic acid (EPA) to prevent the muscle depletion in Lewis lung carcinoma-bearing mice and to test the ability of endurance exercise training to increase the EPA effect. RESULTS: EPA alone did not prevent the muscle loss induced by tumor growth while the combination with exercise induced a partial rescue of muscle strength and mass. Moreover, the association of EPA and exercise reduced the dramatic PAX-7 accumulation and stimulated the increase of PCG-1 protein. CONCLUSIONS: Overall, the present data suggest that exercise is an effective tool that should be added for combined therapeutic approaches against cancer cachexia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13539-011-0028-4) contains supplementary material, which is available to authorized users.

No MeSH data available.


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Liver, spleen, perirenal white adipose tissue (WAT) and tumor weight in control (C) and LLC-bearing mice (LLC). Both groups were subdivided in untreated, EPA-treated (EPA) and EPA-treated plus exercised (EPA EX, see Section 2). Data (means±SD) expressed as percentages of controls. Significance of the differences: ***p < 0.001 vs C; $p < 0.05 vs LLC
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Fig5: Liver, spleen, perirenal white adipose tissue (WAT) and tumor weight in control (C) and LLC-bearing mice (LLC). Both groups were subdivided in untreated, EPA-treated (EPA) and EPA-treated plus exercised (EPA EX, see Section 2). Data (means±SD) expressed as percentages of controls. Significance of the differences: ***p < 0.001 vs C; $p < 0.05 vs LLC

Mentions: Among the other tissues analyzed, liver weight is unchanged in all experimental groups, while spleen mass increases about fourfold in all LLC-bearing animals, independently from the treatment (Fig. 5). The systemic inflammation, suggested by the spleen hypetrophy, is confirmed by the increased circulating levels of γ-IFN (, ). Similar to the spleen weight, EPA administration, alone or in combination with the exercise, does not prevent the γ-IFN raise (, ). Finally, white perirenal adipose tissue virtually disappears in both untreated and treated LLC hosts (Fig. 5).Fig. 5


Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise.

Penna F, Busquets S, Pin F, Toledo M, Baccino FM, López-Soriano FJ, Costelli P, Argilés JM - J Cachexia Sarcopenia Muscle (2011)

Liver, spleen, perirenal white adipose tissue (WAT) and tumor weight in control (C) and LLC-bearing mice (LLC). Both groups were subdivided in untreated, EPA-treated (EPA) and EPA-treated plus exercised (EPA EX, see Section 2). Data (means±SD) expressed as percentages of controls. Significance of the differences: ***p < 0.001 vs C; $p < 0.05 vs LLC
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Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3118004&req=5

Fig5: Liver, spleen, perirenal white adipose tissue (WAT) and tumor weight in control (C) and LLC-bearing mice (LLC). Both groups were subdivided in untreated, EPA-treated (EPA) and EPA-treated plus exercised (EPA EX, see Section 2). Data (means±SD) expressed as percentages of controls. Significance of the differences: ***p < 0.001 vs C; $p < 0.05 vs LLC
Mentions: Among the other tissues analyzed, liver weight is unchanged in all experimental groups, while spleen mass increases about fourfold in all LLC-bearing animals, independently from the treatment (Fig. 5). The systemic inflammation, suggested by the spleen hypetrophy, is confirmed by the increased circulating levels of γ-IFN (, ). Similar to the spleen weight, EPA administration, alone or in combination with the exercise, does not prevent the γ-IFN raise (, ). Finally, white perirenal adipose tissue virtually disappears in both untreated and treated LLC hosts (Fig. 5).Fig. 5

Bottom Line: BACKGROUND: Cancer cachexia is a syndrome characterized by loss of skeletal muscle protein, depletion of lipid stores, anorexia, weakness, and perturbations of the hormonal homeostasis.RESULTS: EPA alone did not prevent the muscle loss induced by tumor growth while the combination with exercise induced a partial rescue of muscle strength and mass.ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13539-011-0028-4) contains supplementary material, which is available to authorized users.

View Article: PubMed Central - PubMed

ABSTRACT
BACKGROUND: Cancer cachexia is a syndrome characterized by loss of skeletal muscle protein, depletion of lipid stores, anorexia, weakness, and perturbations of the hormonal homeostasis. Despite several therapeutic approaches described in the past, effective interventions countering cancer cachexia are still lacking. METHODS: The present work was aimed to verify the ability of eicosapentaenoic acid (EPA) to prevent the muscle depletion in Lewis lung carcinoma-bearing mice and to test the ability of endurance exercise training to increase the EPA effect. RESULTS: EPA alone did not prevent the muscle loss induced by tumor growth while the combination with exercise induced a partial rescue of muscle strength and mass. Moreover, the association of EPA and exercise reduced the dramatic PAX-7 accumulation and stimulated the increase of PCG-1 protein. CONCLUSIONS: Overall, the present data suggest that exercise is an effective tool that should be added for combined therapeutic approaches against cancer cachexia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13539-011-0028-4) contains supplementary material, which is available to authorized users.

No MeSH data available.


Related in: MedlinePlus