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Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise.

Penna F, Busquets S, Pin F, Toledo M, Baccino FM, López-Soriano FJ, Costelli P, Argilés JM - J Cachexia Sarcopenia Muscle (2011)

Bottom Line: BACKGROUND: Cancer cachexia is a syndrome characterized by loss of skeletal muscle protein, depletion of lipid stores, anorexia, weakness, and perturbations of the hormonal homeostasis.RESULTS: EPA alone did not prevent the muscle loss induced by tumor growth while the combination with exercise induced a partial rescue of muscle strength and mass.ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13539-011-0028-4) contains supplementary material, which is available to authorized users.

View Article: PubMed Central - PubMed

ABSTRACT
BACKGROUND: Cancer cachexia is a syndrome characterized by loss of skeletal muscle protein, depletion of lipid stores, anorexia, weakness, and perturbations of the hormonal homeostasis. Despite several therapeutic approaches described in the past, effective interventions countering cancer cachexia are still lacking. METHODS: The present work was aimed to verify the ability of eicosapentaenoic acid (EPA) to prevent the muscle depletion in Lewis lung carcinoma-bearing mice and to test the ability of endurance exercise training to increase the EPA effect. RESULTS: EPA alone did not prevent the muscle loss induced by tumor growth while the combination with exercise induced a partial rescue of muscle strength and mass. Moreover, the association of EPA and exercise reduced the dramatic PAX-7 accumulation and stimulated the increase of PCG-1 protein. CONCLUSIONS: Overall, the present data suggest that exercise is an effective tool that should be added for combined therapeutic approaches against cancer cachexia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13539-011-0028-4) contains supplementary material, which is available to authorized users.

No MeSH data available.


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a Spontaneous locomotor activity in control (C) and LLC-bearing mice (LLC) either untreated or EPA-treated and exercised (EPA EX). Data (means±SD) expressed as percentages of controls. Significance of the differences: **p < 0.01 vs C. b The total activity was subdivided in percentage of resting time, slow movements (between 2 and 5 cm/s) and fast movements (faster than 5 cm/s)
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Fig3: a Spontaneous locomotor activity in control (C) and LLC-bearing mice (LLC) either untreated or EPA-treated and exercised (EPA EX). Data (means±SD) expressed as percentages of controls. Significance of the differences: **p < 0.01 vs C. b The total activity was subdivided in percentage of resting time, slow movements (between 2 and 5 cm/s) and fast movements (faster than 5 cm/s)

Mentions: Analysis of the animal behavior, evaluated for 24 h in a continuous recording activity cage, shows a dramatic fall in the total activity of LLC-bearing mice (Fig. 3a); both fast and slow movements are reduced, the former more markedly than the latter (Fig. 3b). Despite the protection exerted against muscle weight loss, the combination of EPA and exercise reveals unable to prevent the decrease of both total and specific activity induced by LLC growth (Fig. 3a, b). Activity (total or specific) in control groups is qualitatively comparable to the corresponding LLC hosts (Fig. 3a, b).Fig. 3


Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise.

Penna F, Busquets S, Pin F, Toledo M, Baccino FM, López-Soriano FJ, Costelli P, Argilés JM - J Cachexia Sarcopenia Muscle (2011)

a Spontaneous locomotor activity in control (C) and LLC-bearing mice (LLC) either untreated or EPA-treated and exercised (EPA EX). Data (means±SD) expressed as percentages of controls. Significance of the differences: **p < 0.01 vs C. b The total activity was subdivided in percentage of resting time, slow movements (between 2 and 5 cm/s) and fast movements (faster than 5 cm/s)
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Related In: Results  -  Collection

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Fig3: a Spontaneous locomotor activity in control (C) and LLC-bearing mice (LLC) either untreated or EPA-treated and exercised (EPA EX). Data (means±SD) expressed as percentages of controls. Significance of the differences: **p < 0.01 vs C. b The total activity was subdivided in percentage of resting time, slow movements (between 2 and 5 cm/s) and fast movements (faster than 5 cm/s)
Mentions: Analysis of the animal behavior, evaluated for 24 h in a continuous recording activity cage, shows a dramatic fall in the total activity of LLC-bearing mice (Fig. 3a); both fast and slow movements are reduced, the former more markedly than the latter (Fig. 3b). Despite the protection exerted against muscle weight loss, the combination of EPA and exercise reveals unable to prevent the decrease of both total and specific activity induced by LLC growth (Fig. 3a, b). Activity (total or specific) in control groups is qualitatively comparable to the corresponding LLC hosts (Fig. 3a, b).Fig. 3

Bottom Line: BACKGROUND: Cancer cachexia is a syndrome characterized by loss of skeletal muscle protein, depletion of lipid stores, anorexia, weakness, and perturbations of the hormonal homeostasis.RESULTS: EPA alone did not prevent the muscle loss induced by tumor growth while the combination with exercise induced a partial rescue of muscle strength and mass.ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13539-011-0028-4) contains supplementary material, which is available to authorized users.

View Article: PubMed Central - PubMed

ABSTRACT
BACKGROUND: Cancer cachexia is a syndrome characterized by loss of skeletal muscle protein, depletion of lipid stores, anorexia, weakness, and perturbations of the hormonal homeostasis. Despite several therapeutic approaches described in the past, effective interventions countering cancer cachexia are still lacking. METHODS: The present work was aimed to verify the ability of eicosapentaenoic acid (EPA) to prevent the muscle depletion in Lewis lung carcinoma-bearing mice and to test the ability of endurance exercise training to increase the EPA effect. RESULTS: EPA alone did not prevent the muscle loss induced by tumor growth while the combination with exercise induced a partial rescue of muscle strength and mass. Moreover, the association of EPA and exercise reduced the dramatic PAX-7 accumulation and stimulated the increase of PCG-1 protein. CONCLUSIONS: Overall, the present data suggest that exercise is an effective tool that should be added for combined therapeutic approaches against cancer cachexia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13539-011-0028-4) contains supplementary material, which is available to authorized users.

No MeSH data available.


Related in: MedlinePlus