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Unravelling the effects of age, period and cohort on metabolic syndrome components in a Taiwanese population using partial least squares regression.

Tu YK, Chien KL, Burley V, Gilthorpe MS - BMC Med Res Methodol (2011)

Bottom Line: Confounders, such as the number of years in formal education, alcohol intake, smoking history status, and betel-nut chewing were adjusted for.Men born after 1970 had lower FPG, lower BMI, lower DBP, lower TG, Lower LDL and greater HDL; women born after 1970 had lower BMI, lower DBP, lower TG, Lower LDL and greater HDL and UA.This ecological association is worthy of further investigation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Biostatistics, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK. y.k.tu@leeds.ac.uk

ABSTRACT

Background: We investigate whether the changing environment caused by rapid economic growth yielded differential effects for successive Taiwanese generations on 8 components of metabolic syndrome (MetS): body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), triglycerides (TG), high-density lipoprotein (HDL), Low-density lipoproteins (LDL) and uric acid (UA).

Methods: To assess the impact of age, birth year and year of examination on MetS components, we used partial least squares regression to analyze data collected by Mei-Jaw clinics in Taiwan in years 1996 and 2006. Confounders, such as the number of years in formal education, alcohol intake, smoking history status, and betel-nut chewing were adjusted for.

Results: As the age of individuals increased, the values of components generally increased except for UA. Men born after 1970 had lower FPG, lower BMI, lower DBP, lower TG, Lower LDL and greater HDL; women born after 1970 had lower BMI, lower DBP, lower TG, Lower LDL and greater HDL and UA. There is a similar pattern between the trend in levels of metabolic syndrome components against birth year of birth and economic growth in Taiwan.

Conclusions: We found cohort effects in some MetS components, suggesting associations between the changing environment and health outcomes in later life. This ecological association is worthy of further investigation.

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Related in: MedlinePlus

Kernel density plots of body mass index (BMI), fasting plasma glucose (FPG), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG) and high-density lipoproteins (HDL) for men in 1996 (dashed line) and 2006 (solid line).
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Figure 1: Kernel density plots of body mass index (BMI), fasting plasma glucose (FPG), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG) and high-density lipoproteins (HDL) for men in 1996 (dashed line) and 2006 (solid line).

Mentions: The kernel density plots of the eight metabolic syndrome components for men in Figure 1 show that there was little difference in the distributions of BMI, FPG, and TG between 1996 and 2006. The distributions of SBP slightly shifted to the right in the younger age groups in 2006, indicating a small increase in the mean, whilst DBP slightly shifted to the left, showing a small decrease in the mean. The distribution of HDL, however, shifted to the right in 2006 for all age groups, indicating that men had a higher HDL in 2006. The distributions of LDL and UA shifted to the left. The kernel density plots in Figure 2 for women showed that the distributions of BMI and DBP shifted slightly to the left, indicating a small decrease in the means. There was also a left shift in distribution of TG, LDL and UA, though a right shift in HDL.


Unravelling the effects of age, period and cohort on metabolic syndrome components in a Taiwanese population using partial least squares regression.

Tu YK, Chien KL, Burley V, Gilthorpe MS - BMC Med Res Methodol (2011)

Kernel density plots of body mass index (BMI), fasting plasma glucose (FPG), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG) and high-density lipoproteins (HDL) for men in 1996 (dashed line) and 2006 (solid line).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3117818&req=5

Figure 1: Kernel density plots of body mass index (BMI), fasting plasma glucose (FPG), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG) and high-density lipoproteins (HDL) for men in 1996 (dashed line) and 2006 (solid line).
Mentions: The kernel density plots of the eight metabolic syndrome components for men in Figure 1 show that there was little difference in the distributions of BMI, FPG, and TG between 1996 and 2006. The distributions of SBP slightly shifted to the right in the younger age groups in 2006, indicating a small increase in the mean, whilst DBP slightly shifted to the left, showing a small decrease in the mean. The distribution of HDL, however, shifted to the right in 2006 for all age groups, indicating that men had a higher HDL in 2006. The distributions of LDL and UA shifted to the left. The kernel density plots in Figure 2 for women showed that the distributions of BMI and DBP shifted slightly to the left, indicating a small decrease in the means. There was also a left shift in distribution of TG, LDL and UA, though a right shift in HDL.

Bottom Line: Confounders, such as the number of years in formal education, alcohol intake, smoking history status, and betel-nut chewing were adjusted for.Men born after 1970 had lower FPG, lower BMI, lower DBP, lower TG, Lower LDL and greater HDL; women born after 1970 had lower BMI, lower DBP, lower TG, Lower LDL and greater HDL and UA.This ecological association is worthy of further investigation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Biostatistics, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK. y.k.tu@leeds.ac.uk

ABSTRACT

Background: We investigate whether the changing environment caused by rapid economic growth yielded differential effects for successive Taiwanese generations on 8 components of metabolic syndrome (MetS): body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), triglycerides (TG), high-density lipoprotein (HDL), Low-density lipoproteins (LDL) and uric acid (UA).

Methods: To assess the impact of age, birth year and year of examination on MetS components, we used partial least squares regression to analyze data collected by Mei-Jaw clinics in Taiwan in years 1996 and 2006. Confounders, such as the number of years in formal education, alcohol intake, smoking history status, and betel-nut chewing were adjusted for.

Results: As the age of individuals increased, the values of components generally increased except for UA. Men born after 1970 had lower FPG, lower BMI, lower DBP, lower TG, Lower LDL and greater HDL; women born after 1970 had lower BMI, lower DBP, lower TG, Lower LDL and greater HDL and UA. There is a similar pattern between the trend in levels of metabolic syndrome components against birth year of birth and economic growth in Taiwan.

Conclusions: We found cohort effects in some MetS components, suggesting associations between the changing environment and health outcomes in later life. This ecological association is worthy of further investigation.

Show MeSH
Related in: MedlinePlus