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Reduced CSF turnover and decreased ventricular Aβ42 levels are related.

Serot JM, Peltier J, Fichten A, Ledeme N, Bourgeois AM, Jouanny P, Toussaint P, Legars D, Godefroy O, Mazière JC - BMC Neurosci (2011)

Bottom Line: A significant reduction in Aβ42 ventricular levels was observed in 24 / 31 patients with hydrocephalus.The decrease of CSF Aβ42 seems to occur independently of the surgical hydrocephalus aetiology.This suggests that a CSF reduced turnover may play an important role in the decrease of CSF Aβ42 concentration.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Gerontology, CHU Amiens, France. serot.jean-marie@chu-amiens.fr

ABSTRACT

Background: The appearance of Aβ42 peptide deposits is admitted to be a key event in the pathogenesis of Alzheimer's disease, although amyloid deposits also occur in aged non-demented subjects. Aβ42 is a degradation product of the amyloid protein precursor (APP). It can be catabolized by several enzymes, reabsorbed by capillaries or cleared into cerebrospinal fluid (CSF). The possible involvement of a decrease in CSF turnover in A4β2 deposit formation is up to now poorly known. We therefore investigated a possible relationship between a reduced CSF turnover and the CSF levels of the A4β2 peptide.To this aim, CSF of 31 patients with decreased CSF turnover were studied. These patients presented chronic hydrocephalus communicating or obstructive, which required surgery (ventriculostomy or ventriculo-peritoneal shunt). Nine subjects had idiopathic normal pressure hydrocephalus (iNPH), and the other 22 chronic hydrocephalus from other origins (oCH).The Aβ42 peptide concentration was measured by an ELISA test in 31 ventricular CSF samples and in 5 lumbar CSF samples from patients with communicating hydrocephalus.

Results: The 5 patients with lumbar CSF analysis had similar levels of lumbar and ventricular Aβ42. A significant reduction in Aβ42 ventricular levels was observed in 24 / 31 patients with hydrocephalus. The values were lower than 300 pg/ml in 5 out of 9 subjects with iNPH, and in 15 out of 22 subjects with oCH.

Conclusion: The decrease of CSF Aβ42 seems to occur independently of the surgical hydrocephalus aetiology. This suggests that a CSF reduced turnover may play an important role in the decrease of CSF Aβ42 concentration.

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Related in: MedlinePlus

Correlation between lumbar and ventricular CSF levels of Aβ42 (values are expressed in pg/ml; R2 = 0.989, P < 0.0001).
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Figure 1: Correlation between lumbar and ventricular CSF levels of Aβ42 (values are expressed in pg/ml; R2 = 0.989, P < 0.0001).

Mentions: There was no correlation between Aβ42 levels and age. In the 5 patients with lumbar CSF analysis, lumbar and ventricular Aβ42 levels (respectively 415.6± 180.8 pg/ml and 378.4± 189 pg/ml; p>0.05) were found similar and highly correlated (r = 0.99; Figure 1). Based on this fact, Aβ42 ventricular values lower than 500 pg/ml were considered as reduced. This is the case for 24/31 patients (77%), with values under 300 pg/ml in 20 patients (64%) including 5 out of 9 iNPH (55%) and 15 out of 22 oCH (68%; figure 2).


Reduced CSF turnover and decreased ventricular Aβ42 levels are related.

Serot JM, Peltier J, Fichten A, Ledeme N, Bourgeois AM, Jouanny P, Toussaint P, Legars D, Godefroy O, Mazière JC - BMC Neurosci (2011)

Correlation between lumbar and ventricular CSF levels of Aβ42 (values are expressed in pg/ml; R2 = 0.989, P < 0.0001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3117747&req=5

Figure 1: Correlation between lumbar and ventricular CSF levels of Aβ42 (values are expressed in pg/ml; R2 = 0.989, P < 0.0001).
Mentions: There was no correlation between Aβ42 levels and age. In the 5 patients with lumbar CSF analysis, lumbar and ventricular Aβ42 levels (respectively 415.6± 180.8 pg/ml and 378.4± 189 pg/ml; p>0.05) were found similar and highly correlated (r = 0.99; Figure 1). Based on this fact, Aβ42 ventricular values lower than 500 pg/ml were considered as reduced. This is the case for 24/31 patients (77%), with values under 300 pg/ml in 20 patients (64%) including 5 out of 9 iNPH (55%) and 15 out of 22 oCH (68%; figure 2).

Bottom Line: A significant reduction in Aβ42 ventricular levels was observed in 24 / 31 patients with hydrocephalus.The decrease of CSF Aβ42 seems to occur independently of the surgical hydrocephalus aetiology.This suggests that a CSF reduced turnover may play an important role in the decrease of CSF Aβ42 concentration.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Gerontology, CHU Amiens, France. serot.jean-marie@chu-amiens.fr

ABSTRACT

Background: The appearance of Aβ42 peptide deposits is admitted to be a key event in the pathogenesis of Alzheimer's disease, although amyloid deposits also occur in aged non-demented subjects. Aβ42 is a degradation product of the amyloid protein precursor (APP). It can be catabolized by several enzymes, reabsorbed by capillaries or cleared into cerebrospinal fluid (CSF). The possible involvement of a decrease in CSF turnover in A4β2 deposit formation is up to now poorly known. We therefore investigated a possible relationship between a reduced CSF turnover and the CSF levels of the A4β2 peptide.To this aim, CSF of 31 patients with decreased CSF turnover were studied. These patients presented chronic hydrocephalus communicating or obstructive, which required surgery (ventriculostomy or ventriculo-peritoneal shunt). Nine subjects had idiopathic normal pressure hydrocephalus (iNPH), and the other 22 chronic hydrocephalus from other origins (oCH).The Aβ42 peptide concentration was measured by an ELISA test in 31 ventricular CSF samples and in 5 lumbar CSF samples from patients with communicating hydrocephalus.

Results: The 5 patients with lumbar CSF analysis had similar levels of lumbar and ventricular Aβ42. A significant reduction in Aβ42 ventricular levels was observed in 24 / 31 patients with hydrocephalus. The values were lower than 300 pg/ml in 5 out of 9 subjects with iNPH, and in 15 out of 22 subjects with oCH.

Conclusion: The decrease of CSF Aβ42 seems to occur independently of the surgical hydrocephalus aetiology. This suggests that a CSF reduced turnover may play an important role in the decrease of CSF Aβ42 concentration.

Show MeSH
Related in: MedlinePlus