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Intra-ocular melanoma metastatic to an axillary lymph node: a case report.

Anne N, Pallapothu R - World J Surg Oncol (2011)

Bottom Line: Case report.There are few reports of regional spread to the maxillofacial bones.Core biopsy will confirm the diagnosis and tailor subsequent management.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgery, Our Lady of Lourdes Memorial Hospital, Binghamton, NY, USA. nirupamaanne@yahoo.com

ABSTRACT

Background: Unusual metastatic presentation of intra-ocular melanoma.

Study design: Case report.

Discussion: Extra-regional lymphatic spread of intra-ocular melanoma has not been reported previously in the literature. The usual pattern of metastasis for intra-ocular melanoma is hematogenous. There are few reports of regional spread to the maxillofacial bones. We report an interesting case of a 51 year old female with prior history of right eye melanoma, now presenting with metastasis to the left axilla, which is an extra-regional nodal basin.

Conclusion: In female patients presenting with an isolated axillary mass, with a negative breast work up and known prior history of melanoma, the differential diagnosis should include possible metastatic melanoma. Core biopsy will confirm the diagnosis and tailor subsequent management.

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Histopathology image of the core biopsy showing metastatic spindle cell melanoma.
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Figure 3: Histopathology image of the core biopsy showing metastatic spindle cell melanoma.

Mentions: Subsequently, the patient underwent an ultrasound guided left axillary mass core biopsy (Figure 2). Pathology on the core biopsy demonstrated metastatic spindle cell melanoma with necrosis (Figure 3). The patient underwent extensive staging workup including a PET/CT scan which showed a single site of hypermetabolic activity along the left mid-axillary line in the axilla. There was resolution of anatomic findings related to the right orbit (initial site of melanoma) and no adenopathy elsewhere. The solid organs were within normal limits. She was referred to an NCI designated tertiary Institute for a consultation regarding clinical trials for systemic therapy involving interferon based versus surgery and observation.


Intra-ocular melanoma metastatic to an axillary lymph node: a case report.

Anne N, Pallapothu R - World J Surg Oncol (2011)

Histopathology image of the core biopsy showing metastatic spindle cell melanoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3117737&req=5

Figure 3: Histopathology image of the core biopsy showing metastatic spindle cell melanoma.
Mentions: Subsequently, the patient underwent an ultrasound guided left axillary mass core biopsy (Figure 2). Pathology on the core biopsy demonstrated metastatic spindle cell melanoma with necrosis (Figure 3). The patient underwent extensive staging workup including a PET/CT scan which showed a single site of hypermetabolic activity along the left mid-axillary line in the axilla. There was resolution of anatomic findings related to the right orbit (initial site of melanoma) and no adenopathy elsewhere. The solid organs were within normal limits. She was referred to an NCI designated tertiary Institute for a consultation regarding clinical trials for systemic therapy involving interferon based versus surgery and observation.

Bottom Line: Case report.There are few reports of regional spread to the maxillofacial bones.Core biopsy will confirm the diagnosis and tailor subsequent management.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgery, Our Lady of Lourdes Memorial Hospital, Binghamton, NY, USA. nirupamaanne@yahoo.com

ABSTRACT

Background: Unusual metastatic presentation of intra-ocular melanoma.

Study design: Case report.

Discussion: Extra-regional lymphatic spread of intra-ocular melanoma has not been reported previously in the literature. The usual pattern of metastasis for intra-ocular melanoma is hematogenous. There are few reports of regional spread to the maxillofacial bones. We report an interesting case of a 51 year old female with prior history of right eye melanoma, now presenting with metastasis to the left axilla, which is an extra-regional nodal basin.

Conclusion: In female patients presenting with an isolated axillary mass, with a negative breast work up and known prior history of melanoma, the differential diagnosis should include possible metastatic melanoma. Core biopsy will confirm the diagnosis and tailor subsequent management.

Show MeSH
Related in: MedlinePlus