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Extracranial propagation of glioblastoma with extension to pterygomaxillar fossa.

Tomac D, Chudy D, Lambaša S, Topić I, Grahovac G, Zoric A - World J Surg Oncol (2011)

Bottom Line: The patient developed swelling of left temporal region, difficult swallowing and headache.MRI of head showed recurrent tumor, which invaded orbita, ethmoid and sphenoid sinuses, nasal cavity, pterygomaxillar fossa.The current literature is reviewed, and the diagnostic approaches as well as therapeutic options are discussed.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurosurgery, Clinical Hospital Dubrava, Zagreb, Croatia.

ABSTRACT

Background: Glioblastoma multiforme is a highly malignant primary brain tumor that shows marked local aggressiveness, but extracranial spread is not a common occurrence. We present an unusual case of recurrent glioblastoma in 54-year old male that spread through the scull base to the ethmoid and sphenoid sinuses, to the orbita, pterygomaxillar fossa, and to the neck.

Methods: A 54-year old male underwent left temporal resection because of brain tumor of his left temporal lobe. Operation was followed by external beam radiation combined with temozolomide. The tumor recurred eight months after first surgery. The patient developed swelling of left temporal region, difficult swallowing and headache. MRI of head showed recurrent tumor, which invaded orbita, ethmoid and sphenoid sinuses, nasal cavity, pterygomaxillar fossa.

Results: The patient died ten months after initial diagnosis of glioblastoma multiforme, and two months after his second operation.

Conclusions: The aggressive surgical operation helped to downsize the tumor mass as much as possible, but did not prolonged significantly the life or improved the life quality of the patient. The current literature is reviewed, and the diagnostic approaches as well as therapeutic options are discussed.

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Axial T1 weighted contrast enhanced MRI image demonstrating ring-enhanced lesion of the left temporal lobe
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Figure 1: Axial T1 weighted contrast enhanced MRI image demonstrating ring-enhanced lesion of the left temporal lobe

Mentions: (Figure 1) We preformed left temporal osteoplastic craniotomy, and tumor was removed along with the surrounding normal brain tissue (Figure 2). Regression of dysarthria was noticed after the operation, and his Karnofsky score was 100 at discharge. Histopathological analysis confirmed diagnosis of glioblastoma, gradus IV according to WHO. After discharge patient was sent for oncological evaluation.


Extracranial propagation of glioblastoma with extension to pterygomaxillar fossa.

Tomac D, Chudy D, Lambaša S, Topić I, Grahovac G, Zoric A - World J Surg Oncol (2011)

Axial T1 weighted contrast enhanced MRI image demonstrating ring-enhanced lesion of the left temporal lobe
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3117736&req=5

Figure 1: Axial T1 weighted contrast enhanced MRI image demonstrating ring-enhanced lesion of the left temporal lobe
Mentions: (Figure 1) We preformed left temporal osteoplastic craniotomy, and tumor was removed along with the surrounding normal brain tissue (Figure 2). Regression of dysarthria was noticed after the operation, and his Karnofsky score was 100 at discharge. Histopathological analysis confirmed diagnosis of glioblastoma, gradus IV according to WHO. After discharge patient was sent for oncological evaluation.

Bottom Line: The patient developed swelling of left temporal region, difficult swallowing and headache.MRI of head showed recurrent tumor, which invaded orbita, ethmoid and sphenoid sinuses, nasal cavity, pterygomaxillar fossa.The current literature is reviewed, and the diagnostic approaches as well as therapeutic options are discussed.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurosurgery, Clinical Hospital Dubrava, Zagreb, Croatia.

ABSTRACT

Background: Glioblastoma multiforme is a highly malignant primary brain tumor that shows marked local aggressiveness, but extracranial spread is not a common occurrence. We present an unusual case of recurrent glioblastoma in 54-year old male that spread through the scull base to the ethmoid and sphenoid sinuses, to the orbita, pterygomaxillar fossa, and to the neck.

Methods: A 54-year old male underwent left temporal resection because of brain tumor of his left temporal lobe. Operation was followed by external beam radiation combined with temozolomide. The tumor recurred eight months after first surgery. The patient developed swelling of left temporal region, difficult swallowing and headache. MRI of head showed recurrent tumor, which invaded orbita, ethmoid and sphenoid sinuses, nasal cavity, pterygomaxillar fossa.

Results: The patient died ten months after initial diagnosis of glioblastoma multiforme, and two months after his second operation.

Conclusions: The aggressive surgical operation helped to downsize the tumor mass as much as possible, but did not prolonged significantly the life or improved the life quality of the patient. The current literature is reviewed, and the diagnostic approaches as well as therapeutic options are discussed.

Show MeSH
Related in: MedlinePlus