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Adipokine resistin predicts anti-inflammatory effect of glucocorticoids in asthma.

Leivo-Korpela S, Lehtimäki L, Vuolteenaho K, Nieminen R, Kankaanranta H, Saarelainen S, Moilanen E - J Inflamm (Lond) (2011)

Bottom Line: High baseline resistin concentrations were associated with a more pronounced decrease in serum levels of eosinophil cationic protein (ECP) (r = -0.745, p = 0.013), eosinophil protein X (EPX) (r = -0.733, p = 0.016) and myeloperoxidase (MPO) (r = -0.721, p = 0.019) during fluticasone treatment.However, no significant differences in plasma adipokine levels between non-obese asthmatics and healthy controls were found.The effects of resistin were also investigated in human macrophages in cell culture.

View Article: PubMed Central - HTML - PubMed

Affiliation: The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland. eeva.moilanen@uta.fi.

ABSTRACT

Background: Adipokines are protein mediators secreted by adipose tissue. Recently, adipokines have also been involved in the regulation of inflammation and allergic responses, and suggested to affect the risk of asthma especially in obese female patients. We assessed if adipokines predict responsiveness to glucocorticoids and if plasma adipokine levels are associated with lung function or inflammatory activity also in non-obese (body mass index (BMI) ≤ 30 kg/m2) women with newly-diagnosed steroid-naïve asthma.

Methods: Lung function, exhaled NO, plasma levels of adipokines leptin, resistin, adiponectin and adipsin, and inflammatory markers were measured in 35 steroid-naïve female asthmatics and in healthy controls. The measurements were repeated in a subgroup of asthmatics after 8 weeks of treatment with inhaled fluticasone. Adipokine concentrations in plasma were adjusted for BMI.

Results: High baseline resistin concentrations were associated with a more pronounced decrease in serum levels of eosinophil cationic protein (ECP) (r = -0.745, p = 0.013), eosinophil protein X (EPX) (r = -0.733, p = 0.016) and myeloperoxidase (MPO) (r = -0.721, p = 0.019) during fluticasone treatment. In asthmatics, leptin correlated positively with asthma symptom score and negatively with lung function. However, no significant differences in plasma adipokine levels between non-obese asthmatics and healthy controls were found. The effects of resistin were also investigated in human macrophages in cell culture. Interestingly, resistin increased the production of proinflammatory factors IL-6 and TNF-α and that was inhibited by fluticasone.

Conclusions: High resistin levels predicted favourable anti-inflammatory effect of inhaled glucocorticoids suggesting that resistin may be a marker of steroid-sensitive phenotype in asthma. High leptin levels were associated with a more severe disease suggesting that the link between leptin and asthma is not restricted to obesity.

No MeSH data available.


Related in: MedlinePlus

Correlation between leptin and FVC in steroid-naïve asthmatics. BMI-adjusted plasma concentrations of leptin correlated negatively with forced vital capacity (FVC, % predicted) in asthmatics (Spearman's rank correlation), i.e. the higher the BMI adjusted leptin level the lower the FVC (% predicted).
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Figure 3: Correlation between leptin and FVC in steroid-naïve asthmatics. BMI-adjusted plasma concentrations of leptin correlated negatively with forced vital capacity (FVC, % predicted) in asthmatics (Spearman's rank correlation), i.e. the higher the BMI adjusted leptin level the lower the FVC (% predicted).

Mentions: In asthmatics, BMI adjusted leptin correlated positively with asthma symptom score (rho = 0.371, p = 0.031) and negatively with lung volumes VC% predicted (rho = -0.445, p = 0.007), FVC% predicted (rho = -0.406, p = 0.016, Figure 3) and with FEV1% predicted (rho = -0.345, p = 0.045, Figure 4), i.e. the higher the leptin level, the poorer the lung function and the more symptoms. In contrast, BMI adjusted resistin correlated positively with lung volumes VC % predicted (rho = 0.383, p = 0.023) and FVC % predicted (rho = 0.439, p = 0.008) in asthmatics. Adiponectin and adipsin had no correlations with indices of lung function, symptoms or serum markers of inflammation.


Adipokine resistin predicts anti-inflammatory effect of glucocorticoids in asthma.

Leivo-Korpela S, Lehtimäki L, Vuolteenaho K, Nieminen R, Kankaanranta H, Saarelainen S, Moilanen E - J Inflamm (Lond) (2011)

Correlation between leptin and FVC in steroid-naïve asthmatics. BMI-adjusted plasma concentrations of leptin correlated negatively with forced vital capacity (FVC, % predicted) in asthmatics (Spearman's rank correlation), i.e. the higher the BMI adjusted leptin level the lower the FVC (% predicted).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3117675&req=5

Figure 3: Correlation between leptin and FVC in steroid-naïve asthmatics. BMI-adjusted plasma concentrations of leptin correlated negatively with forced vital capacity (FVC, % predicted) in asthmatics (Spearman's rank correlation), i.e. the higher the BMI adjusted leptin level the lower the FVC (% predicted).
Mentions: In asthmatics, BMI adjusted leptin correlated positively with asthma symptom score (rho = 0.371, p = 0.031) and negatively with lung volumes VC% predicted (rho = -0.445, p = 0.007), FVC% predicted (rho = -0.406, p = 0.016, Figure 3) and with FEV1% predicted (rho = -0.345, p = 0.045, Figure 4), i.e. the higher the leptin level, the poorer the lung function and the more symptoms. In contrast, BMI adjusted resistin correlated positively with lung volumes VC % predicted (rho = 0.383, p = 0.023) and FVC % predicted (rho = 0.439, p = 0.008) in asthmatics. Adiponectin and adipsin had no correlations with indices of lung function, symptoms or serum markers of inflammation.

Bottom Line: High baseline resistin concentrations were associated with a more pronounced decrease in serum levels of eosinophil cationic protein (ECP) (r = -0.745, p = 0.013), eosinophil protein X (EPX) (r = -0.733, p = 0.016) and myeloperoxidase (MPO) (r = -0.721, p = 0.019) during fluticasone treatment.However, no significant differences in plasma adipokine levels between non-obese asthmatics and healthy controls were found.The effects of resistin were also investigated in human macrophages in cell culture.

View Article: PubMed Central - HTML - PubMed

Affiliation: The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland. eeva.moilanen@uta.fi.

ABSTRACT

Background: Adipokines are protein mediators secreted by adipose tissue. Recently, adipokines have also been involved in the regulation of inflammation and allergic responses, and suggested to affect the risk of asthma especially in obese female patients. We assessed if adipokines predict responsiveness to glucocorticoids and if plasma adipokine levels are associated with lung function or inflammatory activity also in non-obese (body mass index (BMI) ≤ 30 kg/m2) women with newly-diagnosed steroid-naïve asthma.

Methods: Lung function, exhaled NO, plasma levels of adipokines leptin, resistin, adiponectin and adipsin, and inflammatory markers were measured in 35 steroid-naïve female asthmatics and in healthy controls. The measurements were repeated in a subgroup of asthmatics after 8 weeks of treatment with inhaled fluticasone. Adipokine concentrations in plasma were adjusted for BMI.

Results: High baseline resistin concentrations were associated with a more pronounced decrease in serum levels of eosinophil cationic protein (ECP) (r = -0.745, p = 0.013), eosinophil protein X (EPX) (r = -0.733, p = 0.016) and myeloperoxidase (MPO) (r = -0.721, p = 0.019) during fluticasone treatment. In asthmatics, leptin correlated positively with asthma symptom score and negatively with lung function. However, no significant differences in plasma adipokine levels between non-obese asthmatics and healthy controls were found. The effects of resistin were also investigated in human macrophages in cell culture. Interestingly, resistin increased the production of proinflammatory factors IL-6 and TNF-α and that was inhibited by fluticasone.

Conclusions: High resistin levels predicted favourable anti-inflammatory effect of inhaled glucocorticoids suggesting that resistin may be a marker of steroid-sensitive phenotype in asthma. High leptin levels were associated with a more severe disease suggesting that the link between leptin and asthma is not restricted to obesity.

No MeSH data available.


Related in: MedlinePlus