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Evaluation of nootropic and neuroprotective effects of low dose aspirin in rats.

Ghosh A, Dhumal VR, Tilak AV, Das N, Singh A, Bondekar AA - J Pharmacol Pharmacother (2011)

Bottom Line: Aspirin and ondansetron administration significantly increased the retention of conditioned avoidance response compared to control.Ondansetron and aspirin significantly prevented ECS-induced attenuation of the retention of conditioned avoidance response also.On the other hand, ondansetron and aspirin significantly retarded the ECS-induced enhancement of 5-HT-mediated behavior.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, N.R.S. Medical College, Kolkata, India.

ABSTRACT

Objective: To evaluate the nootropic and neuroprotective effects of aspirin in Sprague Dawley rats.

Materials and methods: Retention of conditioned avoidance response (CAR) and central 5-HT-mediated behavior (lithium-induced head twitches) were assessed using repeated electroconvulsive shock (ECS) in rats. Rats were divided into eight groups: control (pretreated with distilled water), scopolamine (0.5 mg/kg i.p.), ECS (150 V, 50 Hz sinusoidal with intensity of 210 mA for 0.5 s) pretreated, aspirin (6.75 mg/kg orally) pretreated, combined scopolamine and aspirin pretreated, ondansetron (0.36 mg/kg orally) pretreated, combined ECS and ondansetron pretreated and combined ECS and aspirin pretreated groups. Data was analyzed by the chi-square test and ANOVA.

Results: Findings show that administration of single ECS daily for consecutive 8 days results in enhancement of 5-HT-mediated behavior (lithium-induced head twitches) and in disruption of the retention of CAR. Aspirin and ondansetron administration significantly increased the retention of conditioned avoidance response compared to control. Ondansetron and aspirin significantly prevented ECS-induced attenuation of the retention of conditioned avoidance response also. On the other hand, ondansetron and aspirin significantly retarded the ECS-induced enhancement of 5-HT-mediated behavior.

Conclusion: Inhibition of the serotonergic transmission by aspirin is responsible for its nootropic and neuroprotective actions.

No MeSH data available.


Related in: MedlinePlus

Number of lithium-induced head twitches during 31-40 min interval. Gr VII, VIII Vs Gr III (P<0.001)
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Figure 0002: Number of lithium-induced head twitches during 31-40 min interval. Gr VII, VIII Vs Gr III (P<0.001)

Mentions: The number of head twitches induced by injecting lithium chloride was counted every 10 min, starting immediately from the time of injection up to a period of 90 min. The results of this study are shown in Figure 2. The maximum number of head twitches in different groups was seen between 31 and 40 min. So, head twitches at this interval were compared in different groups. The number of head twitches was 0.67± 0.21 (mean ±S.E.M.) in group I. It increased to 58.33±16.17 in group III, and this increase was statistically significant as compared to group I (P<0.001). In comparison to group III, number of head twitches decreased in groups VII and VIII, and this decrease was statistically significant (P<0.001).


Evaluation of nootropic and neuroprotective effects of low dose aspirin in rats.

Ghosh A, Dhumal VR, Tilak AV, Das N, Singh A, Bondekar AA - J Pharmacol Pharmacother (2011)

Number of lithium-induced head twitches during 31-40 min interval. Gr VII, VIII Vs Gr III (P<0.001)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3117566&req=5

Figure 0002: Number of lithium-induced head twitches during 31-40 min interval. Gr VII, VIII Vs Gr III (P<0.001)
Mentions: The number of head twitches induced by injecting lithium chloride was counted every 10 min, starting immediately from the time of injection up to a period of 90 min. The results of this study are shown in Figure 2. The maximum number of head twitches in different groups was seen between 31 and 40 min. So, head twitches at this interval were compared in different groups. The number of head twitches was 0.67± 0.21 (mean ±S.E.M.) in group I. It increased to 58.33±16.17 in group III, and this increase was statistically significant as compared to group I (P<0.001). In comparison to group III, number of head twitches decreased in groups VII and VIII, and this decrease was statistically significant (P<0.001).

Bottom Line: Aspirin and ondansetron administration significantly increased the retention of conditioned avoidance response compared to control.Ondansetron and aspirin significantly prevented ECS-induced attenuation of the retention of conditioned avoidance response also.On the other hand, ondansetron and aspirin significantly retarded the ECS-induced enhancement of 5-HT-mediated behavior.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, N.R.S. Medical College, Kolkata, India.

ABSTRACT

Objective: To evaluate the nootropic and neuroprotective effects of aspirin in Sprague Dawley rats.

Materials and methods: Retention of conditioned avoidance response (CAR) and central 5-HT-mediated behavior (lithium-induced head twitches) were assessed using repeated electroconvulsive shock (ECS) in rats. Rats were divided into eight groups: control (pretreated with distilled water), scopolamine (0.5 mg/kg i.p.), ECS (150 V, 50 Hz sinusoidal with intensity of 210 mA for 0.5 s) pretreated, aspirin (6.75 mg/kg orally) pretreated, combined scopolamine and aspirin pretreated, ondansetron (0.36 mg/kg orally) pretreated, combined ECS and ondansetron pretreated and combined ECS and aspirin pretreated groups. Data was analyzed by the chi-square test and ANOVA.

Results: Findings show that administration of single ECS daily for consecutive 8 days results in enhancement of 5-HT-mediated behavior (lithium-induced head twitches) and in disruption of the retention of CAR. Aspirin and ondansetron administration significantly increased the retention of conditioned avoidance response compared to control. Ondansetron and aspirin significantly prevented ECS-induced attenuation of the retention of conditioned avoidance response also. On the other hand, ondansetron and aspirin significantly retarded the ECS-induced enhancement of 5-HT-mediated behavior.

Conclusion: Inhibition of the serotonergic transmission by aspirin is responsible for its nootropic and neuroprotective actions.

No MeSH data available.


Related in: MedlinePlus