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Adverse drug reactions in inpatients of internal medicine wards at a tertiary care hospital: A prospective cohort study.

Vora MB, Trivedi HR, Shah BK, Tripathi CB - J Pharmacol Pharmacother (2011)

Bottom Line: Most of the fatal and life-threatening reactions occurred due to chemotherapeutic agents.Majority of patients discontinued suspected drug and recovered from ADR.Fatal and life-threatening adverse reactions reported in the present as well as other studies underline the importance of such studies and need for creating awareness among health professionals about looking for and reporting such reactions.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Government Medical College, Bhavnagar, India.

ABSTRACT

Objective: To find out incidence of adverse drug reactions (ADR) in patients of internal medicine wards and study various aspects of ADR, e.g., causality, mortality, drugs commonly causing ADR in internal medicine wards of Guru Gobind Singh Hospital, Jamnagar, a tertiary care hospital.

Materials and methods: This was prospective, observational study carried out at Department of Medicine, Shri Meghji Pethraj Shah Medical College attached with Guru Gobind Singh Hospital, a tertiary care teaching hospital, Jamnagar, Gujarat over a period of 6 months. For statistical analysis, ADR were analyzed by using Chi-square test.

Results: Out of total 860 patients admitted, 830 were analyzed as they met the inclusion criteria. A total of 45 (5.42%) patients developed 47 ADR. Among them, 27 (3.25 %) (95% CI, 2.03, 4.47%) patients due to ADR required hospital admission in medicine ward (ADR Ad), 18 (2.17%) (95% CI, 1.17%-3.17%) patients developed ADR while already hospitalized in medicine ward (ADR In). Most of the fatal and life-threatening reactions occurred due to chemotherapeutic agents. Majority of patients discontinued suspected drug and recovered from ADR.

Conclusion: Fatal and life-threatening adverse reactions reported in the present as well as other studies underline the importance of such studies and need for creating awareness among health professionals about looking for and reporting such reactions.

No MeSH data available.


Related in: MedlinePlus

Seriousness of adverse drug reactions.
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Figure 0003: Seriousness of adverse drug reactions.

Mentions: The causality assessment (World Health Organization causality assessment criteria) of 47 ADR is depicted in Figure 1. Twenty eight (59.57%) ADR classified as “Certain,”; 14 (29.79%) as “Possible.” Among 830 patients studied, 19 groups of drugs were found to cause various ADR. Among these, total 6 drugs from chemotherapeutic group of drugs produced 19 numbers of ADR. Chloroquine phosphate was the most common drug causing ADR [Figure 2]. It was found that 26 (3.13%) patients suffered ADR who received up to 3–5 numbers of drugs, and 16 numbers of patients having ADR received 2 drugs [Table 3]. As far as serious ADR are concerned (as per World Health Organization definition), 2 (4.25%) were fatal, 14 (29.79%) were life-threatening, and 30 (62.83%) required hospitalization (initial or prolonged) [Figure 3]. The management of ADR and outcome are given in tables [Tables 4 and 5, respectively].


Adverse drug reactions in inpatients of internal medicine wards at a tertiary care hospital: A prospective cohort study.

Vora MB, Trivedi HR, Shah BK, Tripathi CB - J Pharmacol Pharmacother (2011)

Seriousness of adverse drug reactions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3117564&req=5

Figure 0003: Seriousness of adverse drug reactions.
Mentions: The causality assessment (World Health Organization causality assessment criteria) of 47 ADR is depicted in Figure 1. Twenty eight (59.57%) ADR classified as “Certain,”; 14 (29.79%) as “Possible.” Among 830 patients studied, 19 groups of drugs were found to cause various ADR. Among these, total 6 drugs from chemotherapeutic group of drugs produced 19 numbers of ADR. Chloroquine phosphate was the most common drug causing ADR [Figure 2]. It was found that 26 (3.13%) patients suffered ADR who received up to 3–5 numbers of drugs, and 16 numbers of patients having ADR received 2 drugs [Table 3]. As far as serious ADR are concerned (as per World Health Organization definition), 2 (4.25%) were fatal, 14 (29.79%) were life-threatening, and 30 (62.83%) required hospitalization (initial or prolonged) [Figure 3]. The management of ADR and outcome are given in tables [Tables 4 and 5, respectively].

Bottom Line: Most of the fatal and life-threatening reactions occurred due to chemotherapeutic agents.Majority of patients discontinued suspected drug and recovered from ADR.Fatal and life-threatening adverse reactions reported in the present as well as other studies underline the importance of such studies and need for creating awareness among health professionals about looking for and reporting such reactions.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Government Medical College, Bhavnagar, India.

ABSTRACT

Objective: To find out incidence of adverse drug reactions (ADR) in patients of internal medicine wards and study various aspects of ADR, e.g., causality, mortality, drugs commonly causing ADR in internal medicine wards of Guru Gobind Singh Hospital, Jamnagar, a tertiary care hospital.

Materials and methods: This was prospective, observational study carried out at Department of Medicine, Shri Meghji Pethraj Shah Medical College attached with Guru Gobind Singh Hospital, a tertiary care teaching hospital, Jamnagar, Gujarat over a period of 6 months. For statistical analysis, ADR were analyzed by using Chi-square test.

Results: Out of total 860 patients admitted, 830 were analyzed as they met the inclusion criteria. A total of 45 (5.42%) patients developed 47 ADR. Among them, 27 (3.25 %) (95% CI, 2.03, 4.47%) patients due to ADR required hospital admission in medicine ward (ADR Ad), 18 (2.17%) (95% CI, 1.17%-3.17%) patients developed ADR while already hospitalized in medicine ward (ADR In). Most of the fatal and life-threatening reactions occurred due to chemotherapeutic agents. Majority of patients discontinued suspected drug and recovered from ADR.

Conclusion: Fatal and life-threatening adverse reactions reported in the present as well as other studies underline the importance of such studies and need for creating awareness among health professionals about looking for and reporting such reactions.

No MeSH data available.


Related in: MedlinePlus