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Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster.

Moskalev A, Shaposhnikov M - Aging (Albany NY) (2011)

Bottom Line: Aging is associated with NF-κB-dependent pro-inflammation.Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia. amoskalev@ib.komisc.ru

ABSTRACT
Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.

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Effect of a NF-κB inhibitor (PDTC) on the survival functions* p<0.001 Kolmogorov-Smirnov test.
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Figure 1: Effect of a NF-κB inhibitor (PDTC) on the survival functions* p<0.001 Kolmogorov-Smirnov test.

Mentions: In males pharmacological inhibition of NF-κB results in an increase of the median (by 20%) lifespan, as well as the age of 90 % mortality (by 14%), compared to males that did not receive PDTC treatment (Table, Figure 1). At the same time, the age-dependent mortality rate was not affected (χ2 = 0; df = 1) (Table, Figure 2). In females, pharmacological inhibition of the NF-κB transcription factor causes an increase in the median (by 13%) and maximum (by 11%) lifespan, as well as the age of 90 % mortality (by 6%), compared to females that did not receive PDTC treatment (Table, Figure 1). The inhibition of NF-κB factor increased the average and median lifespan (by 11-13%). The statistically significant decrease in the age-dependent mortality rate was detected in females as a result of NF-κB inhibitor effect (χ2 = 62.6; df = 1) (Table, Figure 2).


Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster.

Moskalev A, Shaposhnikov M - Aging (Albany NY) (2011)

Effect of a NF-κB inhibitor (PDTC) on the survival functions* p<0.001 Kolmogorov-Smirnov test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3117454&req=5

Figure 1: Effect of a NF-κB inhibitor (PDTC) on the survival functions* p<0.001 Kolmogorov-Smirnov test.
Mentions: In males pharmacological inhibition of NF-κB results in an increase of the median (by 20%) lifespan, as well as the age of 90 % mortality (by 14%), compared to males that did not receive PDTC treatment (Table, Figure 1). At the same time, the age-dependent mortality rate was not affected (χ2 = 0; df = 1) (Table, Figure 2). In females, pharmacological inhibition of the NF-κB transcription factor causes an increase in the median (by 13%) and maximum (by 11%) lifespan, as well as the age of 90 % mortality (by 6%), compared to females that did not receive PDTC treatment (Table, Figure 1). The inhibition of NF-κB factor increased the average and median lifespan (by 11-13%). The statistically significant decrease in the age-dependent mortality rate was detected in females as a result of NF-κB inhibitor effect (χ2 = 62.6; df = 1) (Table, Figure 2).

Bottom Line: Aging is associated with NF-κB-dependent pro-inflammation.Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia. amoskalev@ib.komisc.ru

ABSTRACT
Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.

Show MeSH