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Insights from model organisms on the functions of the tumor suppressor protein LKB1: zebrafish chips in.

van der Velden YU, Haramis AP - Aging (Albany NY) (2011)

Bottom Line: The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy‐metabolism.Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue‐specific and context‐dependent effectors.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands.

ABSTRACT
The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy‐metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue‐specific and context‐dependent effectors.

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Related in: MedlinePlus

Studies of LKB1-deficiency in flies, worms, mice and zebrafish have revealed that the tumor suppressor LKB1 has conserved and divergent roles in the regulation of cell polarization and energy metabolism processes
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Figure 1: Studies of LKB1-deficiency in flies, worms, mice and zebrafish have revealed that the tumor suppressor LKB1 has conserved and divergent roles in the regulation of cell polarization and energy metabolism processes


Insights from model organisms on the functions of the tumor suppressor protein LKB1: zebrafish chips in.

van der Velden YU, Haramis AP - Aging (Albany NY) (2011)

Studies of LKB1-deficiency in flies, worms, mice and zebrafish have revealed that the tumor suppressor LKB1 has conserved and divergent roles in the regulation of cell polarization and energy metabolism processes
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3117450&req=5

Figure 1: Studies of LKB1-deficiency in flies, worms, mice and zebrafish have revealed that the tumor suppressor LKB1 has conserved and divergent roles in the regulation of cell polarization and energy metabolism processes
Bottom Line: The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy‐metabolism.Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue‐specific and context‐dependent effectors.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands.

ABSTRACT
The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy‐metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue‐specific and context‐dependent effectors.

Show MeSH
Related in: MedlinePlus