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Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model.

Maharjan R, Nagar PS, Nampoothiri L - J Ayurveda Integr Med (2010)

Bottom Line: Co-treatment of the inductive agent (letrozole) with the Aloe vera gel prevented the development of the PCO phenotype.Aloe vera gel formulation exerts a protective effect in against the PCOS phenotype by restoring the ovarian steroid status, and altering key steroidogenic activity.This can be attributed to phyto-components present in the extract.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, M.S. University of Baroda, Vadodara, Gujarat, India.

ABSTRACT
This is a preliminary study that explores the efficacy of Aloe vera gel formulation as a possible therapeutic agent in the prevention and management of polycystic ovary syndrome (PCOS). PCOS is recognized as the most common endocrinopathy of women. Increased androgen synthesis, disrupted folliculogenesis, and insulin resistance lie at the patho-physiological core of PCOS. Current therapy for such a syndrome is use of insulin sensitizers. Large randomized clinical trials of metformin as the insulin-sensitizing drug, however, suggested that it produces many side effects after prolonged usage. For this reason, an alternate therapy would be to use herbs with hypoglycemic potential. Aloe barbadensis Mill. (Liliaceae) popularly known as Aloe vera is a well-known plant with such properties. The present study evaluated the efficacy of Aloe vera gel formulation in a PCOS rat model. Five month old Charles Foster female rats were orally fed with letrozole, a non-steroidal aromatase inhibitor, to induce PCOS. The rats were then treated orally with the Aloe vera gel formulation (1 ml dose daily for 45 days). This restored their estrus cyclicity, glucose sensitivity, and steroidogenic activity. Co-treatment of the inductive agent (letrozole) with the Aloe vera gel prevented the development of the PCO phenotype. Aloe vera gel formulation exerts a protective effect in against the PCOS phenotype by restoring the ovarian steroid status, and altering key steroidogenic activity. This can be attributed to phyto-components present in the extract.

No MeSH data available.


Related in: MedlinePlus

Effect oral administration of aloe vera gel formulation (1 ml/45 days) on follicular growth of ovary in letrozole induced PCOS rats (a) CMC control rat showing normal follicular development (H and E ×10) b: Section of ovary from letrozole treated showing small cysts in the follicle (x10) c: Section of ovary from aloe treated group showing normal follicle growth (x10) d: Section of ovary from metformin treated group showing normal primary follicle growth (x10)
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Figure 0002: Effect oral administration of aloe vera gel formulation (1 ml/45 days) on follicular growth of ovary in letrozole induced PCOS rats (a) CMC control rat showing normal follicular development (H and E ×10) b: Section of ovary from letrozole treated showing small cysts in the follicle (x10) c: Section of ovary from aloe treated group showing normal follicle growth (x10) d: Section of ovary from metformin treated group showing normal primary follicle growth (x10)

Mentions: Rats treated with letrozole for induction of PCOS showed significant increases in body weight and ovarian weight, and altered estrus cyclicity compared to controls. PCOS positive animals exhibited an increase in glucose intolerance compared to controls. [Figure 1]. PCOS rats exhibited many small atretic cysts [Figure 2b], whereas no histological abnormalities were observed in control rats [Figure 2a]. Key ovarian steroidogenic enzymes 3β hydroxysteroid dehydrogenase and 17β hydroxysteroid dehydrogenase showed increases in activity in letrozole induced PCOS rats compared to control rats. [Figure 3]


Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model.

Maharjan R, Nagar PS, Nampoothiri L - J Ayurveda Integr Med (2010)

Effect oral administration of aloe vera gel formulation (1 ml/45 days) on follicular growth of ovary in letrozole induced PCOS rats (a) CMC control rat showing normal follicular development (H and E ×10) b: Section of ovary from letrozole treated showing small cysts in the follicle (x10) c: Section of ovary from aloe treated group showing normal follicle growth (x10) d: Section of ovary from metformin treated group showing normal primary follicle growth (x10)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3117319&req=5

Figure 0002: Effect oral administration of aloe vera gel formulation (1 ml/45 days) on follicular growth of ovary in letrozole induced PCOS rats (a) CMC control rat showing normal follicular development (H and E ×10) b: Section of ovary from letrozole treated showing small cysts in the follicle (x10) c: Section of ovary from aloe treated group showing normal follicle growth (x10) d: Section of ovary from metformin treated group showing normal primary follicle growth (x10)
Mentions: Rats treated with letrozole for induction of PCOS showed significant increases in body weight and ovarian weight, and altered estrus cyclicity compared to controls. PCOS positive animals exhibited an increase in glucose intolerance compared to controls. [Figure 1]. PCOS rats exhibited many small atretic cysts [Figure 2b], whereas no histological abnormalities were observed in control rats [Figure 2a]. Key ovarian steroidogenic enzymes 3β hydroxysteroid dehydrogenase and 17β hydroxysteroid dehydrogenase showed increases in activity in letrozole induced PCOS rats compared to control rats. [Figure 3]

Bottom Line: Co-treatment of the inductive agent (letrozole) with the Aloe vera gel prevented the development of the PCO phenotype.Aloe vera gel formulation exerts a protective effect in against the PCOS phenotype by restoring the ovarian steroid status, and altering key steroidogenic activity.This can be attributed to phyto-components present in the extract.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, M.S. University of Baroda, Vadodara, Gujarat, India.

ABSTRACT
This is a preliminary study that explores the efficacy of Aloe vera gel formulation as a possible therapeutic agent in the prevention and management of polycystic ovary syndrome (PCOS). PCOS is recognized as the most common endocrinopathy of women. Increased androgen synthesis, disrupted folliculogenesis, and insulin resistance lie at the patho-physiological core of PCOS. Current therapy for such a syndrome is use of insulin sensitizers. Large randomized clinical trials of metformin as the insulin-sensitizing drug, however, suggested that it produces many side effects after prolonged usage. For this reason, an alternate therapy would be to use herbs with hypoglycemic potential. Aloe barbadensis Mill. (Liliaceae) popularly known as Aloe vera is a well-known plant with such properties. The present study evaluated the efficacy of Aloe vera gel formulation in a PCOS rat model. Five month old Charles Foster female rats were orally fed with letrozole, a non-steroidal aromatase inhibitor, to induce PCOS. The rats were then treated orally with the Aloe vera gel formulation (1 ml dose daily for 45 days). This restored their estrus cyclicity, glucose sensitivity, and steroidogenic activity. Co-treatment of the inductive agent (letrozole) with the Aloe vera gel prevented the development of the PCO phenotype. Aloe vera gel formulation exerts a protective effect in against the PCOS phenotype by restoring the ovarian steroid status, and altering key steroidogenic activity. This can be attributed to phyto-components present in the extract.

No MeSH data available.


Related in: MedlinePlus