Limits...
Phytochemical and pharmacological review of Lagenaria sicereria.

Prajapati RP, Kalariya M, Parmar SK, Sheth NR - J Ayurveda Integr Med (2010)

Bottom Line: A wide range of chemical compounds including sterols, terpenoids, flavonoids, and saponins have been isolated from the species.Its extracts have been found to possess various pharmacological activities.Particular attention is given to its analgesic, anti-inflammatory, antihyperlipidemic, diuretic, hepatoprotective, anthelmintic, and antibacterial effects so that its potential uses in pharmaceutics can be better evaluated.

View Article: PubMed Central - PubMed

Affiliation: Saurashtra University, Rajkot, Gujarat, India.

ABSTRACT
Lagenaria siceraria (Molina) standley (LS) (Family: Cucurbitaceae) is an annual herbaceous climbing plant with a long history of traditional medicinal uses in many countries, especially in tropical and subtropical regions. Since ancient times the climber has been known for its curative properties, and has been utilized for treatment of various ailments, including jaundice, diabetes, ulcer, piles, colitis, insanity, hypertension, congestive cardiac failure (CCF), and skin diseases. Its fruit pulp is used both as an emetic and purgative, and for its cooling, diuretic, antibilious, and pectoral properties. Boiled in oil this pulp is used to treat rheumatism and insomnia. A wide range of chemical compounds including sterols, terpenoids, flavonoids, and saponins have been isolated from the species. Its extracts have been found to possess various pharmacological activities. Below, we give a comprehensive review of its ethnomedical uses, chemical constituents, and pharmacological profile as a medicinal plant. Particular attention is given to its analgesic, anti-inflammatory, antihyperlipidemic, diuretic, hepatoprotective, anthelmintic, and antibacterial effects so that its potential uses in pharmaceutics can be better evaluated.

No MeSH data available.


Related in: MedlinePlus

Structure of flavone C-glycosides from L. siceraria
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3117318&req=5

Figure 0003: Structure of flavone C-glycosides from L. siceraria

Mentions: Chen et al, isolated four new d:C-friedooleanane-type triterpenes, 3 b-O-(E)-feruloyl-D:C-friedooleana-7, 9 (11)-dien-29-ol (1), 3b-O-(E)-coumaroyl-D:C-friedooleana-7,9(11)-dien-29-ol (2), 3b-O-(E) coumaroyl-d:C-friedooleana-7,9 (11)-dien-29-oic acid (3), and methyl 2 b,3 b-dihydroxy-D:C-friedoolean-8-en-29-oate (6), together with five known triterpenes with the same skeleton, 3-epikarounidiol (4), 3-oxo-d:C-friedoolena-7, 9 (11)-dien-29-oic acid (5), bryonolol (7), bryononic acid (8), and 20-epibryonolic acid (9) from the methanol extract of the stems of plant. Compounds 3 and 9 showed significant cytotoxic activity against the SK-Hep 1 cell line with IC50 values of 4.8[14][Figure 3 and 4, Table 2].


Phytochemical and pharmacological review of Lagenaria sicereria.

Prajapati RP, Kalariya M, Parmar SK, Sheth NR - J Ayurveda Integr Med (2010)

Structure of flavone C-glycosides from L. siceraria
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3117318&req=5

Figure 0003: Structure of flavone C-glycosides from L. siceraria
Mentions: Chen et al, isolated four new d:C-friedooleanane-type triterpenes, 3 b-O-(E)-feruloyl-D:C-friedooleana-7, 9 (11)-dien-29-ol (1), 3b-O-(E)-coumaroyl-D:C-friedooleana-7,9(11)-dien-29-ol (2), 3b-O-(E) coumaroyl-d:C-friedooleana-7,9 (11)-dien-29-oic acid (3), and methyl 2 b,3 b-dihydroxy-D:C-friedoolean-8-en-29-oate (6), together with five known triterpenes with the same skeleton, 3-epikarounidiol (4), 3-oxo-d:C-friedoolena-7, 9 (11)-dien-29-oic acid (5), bryonolol (7), bryononic acid (8), and 20-epibryonolic acid (9) from the methanol extract of the stems of plant. Compounds 3 and 9 showed significant cytotoxic activity against the SK-Hep 1 cell line with IC50 values of 4.8[14][Figure 3 and 4, Table 2].

Bottom Line: A wide range of chemical compounds including sterols, terpenoids, flavonoids, and saponins have been isolated from the species.Its extracts have been found to possess various pharmacological activities.Particular attention is given to its analgesic, anti-inflammatory, antihyperlipidemic, diuretic, hepatoprotective, anthelmintic, and antibacterial effects so that its potential uses in pharmaceutics can be better evaluated.

View Article: PubMed Central - PubMed

Affiliation: Saurashtra University, Rajkot, Gujarat, India.

ABSTRACT
Lagenaria siceraria (Molina) standley (LS) (Family: Cucurbitaceae) is an annual herbaceous climbing plant with a long history of traditional medicinal uses in many countries, especially in tropical and subtropical regions. Since ancient times the climber has been known for its curative properties, and has been utilized for treatment of various ailments, including jaundice, diabetes, ulcer, piles, colitis, insanity, hypertension, congestive cardiac failure (CCF), and skin diseases. Its fruit pulp is used both as an emetic and purgative, and for its cooling, diuretic, antibilious, and pectoral properties. Boiled in oil this pulp is used to treat rheumatism and insomnia. A wide range of chemical compounds including sterols, terpenoids, flavonoids, and saponins have been isolated from the species. Its extracts have been found to possess various pharmacological activities. Below, we give a comprehensive review of its ethnomedical uses, chemical constituents, and pharmacological profile as a medicinal plant. Particular attention is given to its analgesic, anti-inflammatory, antihyperlipidemic, diuretic, hepatoprotective, anthelmintic, and antibacterial effects so that its potential uses in pharmaceutics can be better evaluated.

No MeSH data available.


Related in: MedlinePlus